pI: 8.5717 |
Length (AA): 517 |
MW (Da): 59421 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Bloodstream Form. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127350)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G20290 | EPS15 homology domain 1 protein |
Arabidopsis thaliana | AT4G05520 | EPS15 homology domain 2 protein |
Brugia malayi | Bm1_25225 | EH-domain containing protein 3 |
Caenorhabditis elegans | CELE_W06H8.1 | Protein RME-1, isoform F |
Dictyostelium discoideum | DDB_G0282233 | hypothetical protein |
Drosophila melanogaster | Dmel_CG6148 | Putative Achaete Scute Target 1 |
Echinococcus granulosus | EgrG_000851900 | Receptor Mediated Endocytosis family member |
Entamoeba histolytica | EHI_052870 | ENTH domain protein, putative |
Entamoeba histolytica | EHI_152680 | EH-domain containing protein, putative |
Entamoeba histolytica | EHI_105270 | Receptor mediated endocytosis protein, putative |
Echinococcus multilocularis | EmuJ_000851900 | Receptor Mediated Endocytosis family member |
Homo sapiens | ENSG00000110047 | EH-domain containing 1 |
Homo sapiens | ENSG00000024422 | EH-domain containing 2 |
Homo sapiens | 30845 | EH-domain containing 3 |
Homo sapiens | 30844 | EH-domain containing 4 |
Leishmania braziliensis | LbrM.19.0590 | sarcoplasmic reticulum glycoprotein, putative,sarcalumenin precursor, putative |
Leishmania braziliensis | LbrM.20.1770 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_190270.1 | Sarcalumenin, putative |
Leishmania donovani | LdBPK_342040.1 | Dynamin family, putative |
Leishmania infantum | LinJ.34.2040 | hypothetical protein, conserved |
Leishmania infantum | LinJ.19.0270 | sarcoplasmic reticulum glycoprotein, putative,sarcalumenin precursor, putative |
Leishmania major | LmjF.19.0280 | sarcoplasmic reticulum glycoprotein, putative,sarcalumenin precursor, putative |
Leishmania major | LmjF.34.2270 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.19.0280 | sarcoplasmic reticulum glycoprotein, putative,sarcalumenin precursor, putative |
Leishmania mexicana | LmxM.33.2270 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_11153 | EH-domain-containing protein 3 |
Loa Loa (eye worm) | LOAG_01942 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12119 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13090 | hypothetical protein |
Mus musculus | 259300 | EH-domain containing 2 |
Mus musculus | ENSMUSG00000027293 | EH-domain containing 4 |
Mus musculus | ENSMUSG00000024065 | EH-domain containing 3 |
Mus musculus | ENSMUSG00000024772 | EH-domain containing 1 |
Neospora caninum | NCLIV_031580 | GA19392, related |
Oryza sativa | 4341894 | Os06g0687800 |
Oryza sativa | 4328363 | Os02g0158100 |
Oryza sativa | 4337342 | Os04g0669300 |
Onchocerca volvulus | OVOC8114 |
|
Onchocerca volvulus | OVOC9312 |
|
Plasmodium berghei | PBANKA_0402800 | EH domain-containing protein, putative |
Plasmodium falciparum | PF3D7_0304200 | EH domain-containing protein |
Plasmodium knowlesi | PKNH_0838900 | EH domain-containing protein, putative |
Plasmodium vivax | PVX_119335 | EH (for Eps15 Homology) domain containing protein |
Plasmodium yoelii | PY03528 | Plasmodium vivax PV1H14130_P |
Schistosoma japonicum | Sjp_0301270 | EH domain-containing protein 1, putative |
Schistosoma japonicum | Sjp_0002850 | EH domain-containing protein 1, putative |
Schistosoma mansoni | Smp_065180 | eh domain containing/past-1-related |
Schistosoma mansoni | Smp_019100 | eh domain containing/past-1-related |
Schmidtea mediterranea | mk4.002630.01 | |
Schmidtea mediterranea | mk4.009408.00 | |
Schmidtea mediterranea | mk4.000000.55 | |
Schmidtea mediterranea | mk4.003056.05 | |
Trypanosoma brucei gambiense | Tbg972.4.2340 | sarcoplasmic reticulum glycoprotein, putative |
Trypanosoma brucei gambiense | Tbg972.10.18120 | sarcoplasmic reticulum glycoprotein, putative,sarcalumenin precursor, putative |
Trypanosoma brucei | Tb927.10.14910 | Sarcalumenin, putative |
Trypanosoma brucei | Tb927.4.2380 | sarcoplasmic reticulum glycoprotein, putative |
Trypanosoma congolense | TcIL3000_10_12790 | Sarcalumenin, putative |
Trypanosoma cruzi | TcCLB.506559.270 | sarcoplasmic reticulum glycoprotein, putative |
Trypanosoma cruzi | TcCLB.506211.100 | Sarcalumenin, putative |
Trypanosoma cruzi | TcCLB.508895.30 | Sarcalumenin, putative |
Toxoplasma gondii | TGME49_231210 | sarcalumenin/eps15 family protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14910 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14910 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14910 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.14910 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.4.2380 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.2380 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.2380 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.2380 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_W06H8.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_0402800 | Plasmodium berghei | Dispensable | plasmo |
TGME49_231210 | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.