pI: 8.1207 |
Length (AA): 550 |
MW (Da): 64234 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127427)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G23575 | transmembrane CLPTM1 family protein |
Arabidopsis thaliana | AT5G08500 | transmembrane CLPTM1 family protein |
Babesia bovis | BBOV_IV011540 | transmembrane CLPTM1 family protein |
Brugia malayi | Bm1_42235 | cisplatin |
Brugia malayi | Bm1_06285 | cleft lip and palate associated transmembrane protein 1 |
Caenorhabditis elegans | CELE_T13H5.8 | Protein T13H5.8 |
Caenorhabditis elegans | CELE_C36B7.6 | Protein C36B7.6 |
Caenorhabditis elegans | CELE_R166.2 | Protein R166.2 |
Cryptosporidium hominis | Chro.70367 | strong similar to -related |
Cryptosporidium parvum | cgd7_3290 | cleft lip and palate family of eukaryotic membrane proteins (potential transporters) with 9 transmembrane domains |
Dictyostelium discoideum | DDB_G0283115 | cleft lip and palate transmembrane 1 family protein |
Drosophila melanogaster | Dmel_CG3702 | CG3702 gene product from transcript CG3702-RA |
Drosophila melanogaster | Dmel_CG4332 | CG4332 gene product from transcript CG4332-RA |
Echinococcus granulosus | EgrG_000836900 | cleft lip and palate transmembrane protein |
Echinococcus granulosus | EgrG_000456700 | Cleft lip and palate transmembrane protein 1 |
Entamoeba histolytica | EHI_130850 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000836900 | cleft lip and palate transmembrane protein |
Echinococcus multilocularis | EmuJ_000456700 | Cleft lip and palate transmembrane protein 1 |
Homo sapiens | ENSG00000049656 | CLPTM1-like |
Homo sapiens | ENSG00000104853 | cleft lip and palate associated transmembrane protein 1 |
Leishmania braziliensis | LbrM.20.0130 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_340050.1 | Cleft lip and palate transmembrane protein 1 (CLPTM1), putative |
Leishmania infantum | LinJ.34.0050 | hypothetical protein, conserved |
Leishmania major | LmjF.34.0050 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.33.0050 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_01087 | cisplatin |
Loa Loa (eye worm) | LOAG_08433 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15076 | hypothetical protein |
Mus musculus | ENSMUSG00000021610 | CLPTM1-like |
Mus musculus | ENSMUSG00000002981 | cleft lip and palate associated transmembrane protein 1 |
Neospora caninum | NCLIV_020430 | hypothetical protein |
Oryza sativa | 4335933 | Os04g0441900 |
Onchocerca volvulus | OVOC5403 | Cleft lip and palate transmembrane protein 1 homolog |
Plasmodium berghei | PBANKA_0911400 | CLPTM1 domain-containing protein, putative |
Plasmodium falciparum | PF3D7_1137300 | CLPTM1 domain-containing protein, putative |
Plasmodium knowlesi | PKNH_0935500 | CLPTM1 domain-containing protein, putative |
Plasmodium vivax | PVX_092480 | hypothetical protein, conserved |
Plasmodium yoelii | PY01217 | strong similarity to unknown protein-related |
Schistosoma japonicum | Sjp_0205000 | Cleft lip and palate transmembrane protein 1 homolog, putative |
Schistosoma japonicum | Sjp_0302340 | Cleft lip and palate transmembrane protein 1-like protein, putative |
Schistosoma mansoni | Smp_175170 | cleft lip and palate associated transmembrane protein-related |
Schistosoma mansoni | Smp_145250 | hypothetical protein |
Schmidtea mediterranea | mk4.002766.01 | Cleft lip and palate transmembrane protein 1 |
Schmidtea mediterranea | mk4.000115.01 | |
Trypanosoma brucei gambiense | Tbg972.10.3060 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.2470 | Cleft lip and palate transmembrane protein 1 (CLPTM1), putative |
Trypanosoma congolense | TcIL3000_10_2100 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.503745.20 | Cleft lip and palate transmembrane protein 1 (CLPTM1), putative |
Trypanosoma cruzi | TcCLB.506193.20 | Cleft lip and palate transmembrane protein 1 (CLPTM1), putative |
Toxoplasma gondii | TGME49_205240 | cleft lip and palate transmembrane protein 1 (clptm1) protein |
Theileria parva | TP01_1151 | hypothetical protein |
Trichomonas vaginalis | TVAG_515920 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_413020 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_248720 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.2470 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.2470 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.2470 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.2470 this record | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0911400 | Plasmodium berghei | Slow | plasmo |
TGME49_205240 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.