pI: 8.3846 |
Length (AA): 480 |
MW (Da): 53711 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128574)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G05380 | AAA-type ATPase family protein |
Brugia malayi | Bm1_30135 | mitochondrial chaperone BCS1 |
Candida albicans | CaO19.458 | Mitochondrial ATPase (AAA type). |
Candida albicans | CaO19.8089 | Mitochondrial ATPase (AAA type). |
Caenorhabditis elegans | CELE_F54C9.6 | Protein BCS-1, isoform B |
Dictyostelium discoideum | DDB_G0291910 | mitochondrial ATPase |
Dictyostelium discoideum | DDB_G0289135 | mitochondrial ATPase |
Drosophila melanogaster | Dmel_CG4908 | CG4908 gene product from transcript CG4908-RB |
Echinococcus granulosus | EgrG_001078300 | mitochondrial chaperone BCS1 |
Echinococcus granulosus | EgrG_001078400 | mitochondrial chaperone BCS1 |
Echinococcus multilocularis | EmuJ_001078400 | mitochondrial chaperone BCS1 |
Echinococcus multilocularis | EmuJ_001078300 | mitochondrial chaperone BCS1 |
Homo sapiens | ENSG00000074582 | BC1 (ubiquinol-cytochrome c reductase) synthesis-like |
Leishmania braziliensis | LbrM.20.1360 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_341440.1 | BCS1 N terminal/ATPase family associated with various cellular activities (AAA), putative |
Leishmania infantum | LinJ.34.1440 | hypothetical protein, conserved |
Leishmania major | LmjF.34.1330 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.33.1330 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_07266 | chaperone BCS1 |
Mus musculus | ENSMUSG00000026172 | BCS1-like (yeast) |
Neospora caninum | NCLIV_018220 | Mitochondrial protein-like, related |
Oryza sativa | 4333339 | Os03g0584400 |
Oryza sativa | 4326559 | Os01g0641800 |
Oryza sativa | 4343389 | Os07g0517600 |
Plasmodium berghei | PBANKA_0102000 | mitochondrial chaperone BCS1, putative |
Plasmodium falciparum | PF3D7_0603200 | mitochondrial chaperone BCS1, putative |
Plasmodium knowlesi | PKNH_1147500 | mitochondrial chaperone BCS1, putative |
Plasmodium vivax | PVX_113325 | mitochondrial chaperone BCS1, putative |
Plasmodium yoelii | PY02578 | bcs1 protein |
Saccharomyces cerevisiae | YDR375C | bifunctional AAA family ATPase chaperone/translocase BCS1 |
Schistosoma japonicum | Sjp_0062800 | ko:K08900 mitochondrial chaperone BCS1, putative |
Schistosoma mansoni | Smp_083120 | mitochondrial chaperone BCS1 |
Schmidtea mediterranea | mk4.000282.07 | Mitochondrial chaperone BCS1 |
Trypanosoma brucei gambiense | Tbg972.8.3290 | ATP-dependent chaperone, putative,mitochondrial chaperone BCS1, putative |
Trypanosoma brucei | Tb927.8.3580 | mitochondrial chaperone BCS1, putative |
Trypanosoma congolense | TcIL3000_8_3540 | ATP-dependent chaperone, putative |
Trypanosoma cruzi | TcCLB.509553.20 | ATP-dependent chaperone, putative |
Trypanosoma cruzi | TcCLB.505945.50 | ATP-dependent chaperone, putative |
Toxoplasma gondii | TGME49_243490 | BCS1 family isoform 9, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.3580 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3580 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3580 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.3580 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F54C9.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F54C9.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F54C9.6 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_0102000 | Plasmodium berghei | Essential | plasmo |
TGME49_243490 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.