Detailed view for PF3D7_0803000

Basic information

TDR Targets ID: 1061
Plasmodium falciparum, peptidyl-prolyl cis-trans isomerase
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.7601 | Length (AA): 677 | MW (Da): 80923 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00160   Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
PF08231   SYF2 splicing factor

Gene Ontology

Mouse over links to read term descriptions.
GO:0000413   protein peptidyl-prolyl isomerization  
GO:0003755   peptidyl-prolyl cis-trans isomerase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 14 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 264 1ihg (A) 13 235 26.00 0 1 0.49 0.32
4 219 2bit (X) 3 165 29.00 0 1 0.38 -0.13
2 218 1qng (A) 2 171 32.00 0 1 0.422032 0.12
2 218 1a58 (A) 4 176 28.00 0.00026 1 0.430732 0.13
3 218 2wfi (A) 6 177 29.00 0 1 0.418555 -0.06
3 225 2ose (A) 13 213 25.00 0.00019 1 0.262894 0.3
6 219 3ici (A) 13 174 31.00 0 1 0.3636 0.06
7 218 1z81 (A) 43 210 31.00 0.0045 1 0.414346 0.02
17 231 1zkc (A) 287 447 23.00 0.00000038 1 0.169078 0.82
490 671 4uos (A) 1 183 10.00 0.29 0 0.464833 -1.31
1 218 2igv (A) 1 171 29.00 0.000076 1 0.393585 0.4
2 218 1a58 (A) 4 176 28.00 0.00032 1 0.437106 0.05
3 218 1qng (A) 3 171 33.00 0.0000021 1 0.453627 0.17
489 670 4uos (A) 1 183 10.00 0.55 0 0.468031 -1.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Oocyst. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, early schizont, late ring, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 32 hs, merozoite, sporozoite, early ring, early trophozoite, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte. Otto TD PlasmoDB
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_139999)

Species Accession Gene Product
Babesia bovis BBOV_IV006890   peptidyl-prolyl cis-trans isomerase, putative
Caenorhabditis elegans CELE_T27D1.1   Protein CYN-9
Neospora caninum NCLIV_030640   peptidyl-prolyl cis-trans isomerase, cyclophylin protein, putative
Plasmodium berghei PBANKA_1227200   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium falciparum PF3D7_0803000   peptidyl-prolyl cis-trans isomerase
Plasmodium knowlesi PKNH_0115900   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium vivax PVX_093595   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium yoelii PY05631   Drosophila melanogaster CG12343 gene product, putative
Toxoplasma gondii TGME49_229940   cyclophilin, putative
Theileria parva TP03_0222   peptidyl-prolyl cis-trans isomerase, putative
Theileria parva TP03_0221   hypothetical protein, conserved
Trichomonas vaginalis TVAG_536100   ubiquitin-protein ligase bre-1, putative

Essentiality

PF3D7_0803000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_229940 Toxoplasma gondii Probably non-essential sidik
TGME49_229940 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Cyclophilin A 164 aa 23.6% 212 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0803000 (Plasmodium falciparum), peptidyl-prolyl cis-trans isomerase
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