Detailed view for Tb927.9.2020

Basic information

TDR Targets ID: 10690
Trypanosoma brucei, 60S ribosomal protein L38, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.2363 | Length (AA): 82 | MW (Da): 9500 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01781   Ribosomal L38e protein family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

PDB tag
  • 3ZF7:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_127448)

Species Accession Gene Product
Arabidopsis thaliana AT2G43460   60S ribosomal protein L38
Arabidopsis thaliana AT3G59540   60S ribosomal protein L38
Babesia bovis BBOV_IV004550   ribosomal protein L38e, putative
Brugia malayi Bm1_30500   60S ribosomal protein L38
Caenorhabditis elegans CELE_C06B8.8   Protein RPL-38
Cryptosporidium hominis Chro.70450   hypothetical protein
Cryptosporidium parvum cgd7_4050   ribosomal protein L38
Dictyostelium discoideum DDB_G0268302   S60 ribosomal protein L38
Drosophila melanogaster Dmel_CG18001   Ribosomal protein L38
Echinococcus granulosus EgrG_000488100   60S ribosomal protein L38
Entamoeba histolytica EHI_099790   60S ribosomal protein L38, putative
Entamoeba histolytica EHI_023840   60S ribosomal protein L38, putative
Echinococcus multilocularis EmuJ_000488100   60S ribosomal protein L38
Homo sapiens ENSG00000172809   ribosomal protein L38
Leishmania braziliensis LbrM.03.0260   ribosomal protein L38, putative
Leishmania braziliensis LbrM.26.2140   ribosomal protein L38, putative
Leishmania donovani LdBPK_262230.1   ribosomal protein L38, putative
Leishmania donovani LdBPK_030240.1   ribosomal protein L38, putative
Leishmania infantum LinJ.03.0240   ribosomal protein L38, putative
Leishmania infantum LinJ.26.2230   ribosomal protein L38, putative
Leishmania major LmjF.03.0250   ribosomal protein L38, putative
Leishmania major LmjF.26.2220   ribosomal protein L38, putative
Leishmania mexicana LmxM.26.2220   ribosomal protein L38, putative
Leishmania mexicana LmxM.03.0250   ribosomal protein L38, putative
Loa Loa (eye worm) LOAG_05331   60S ribosomal protein L38
Loa Loa (eye worm) LOAG_04518   ribosomal protein L38
Mus musculus ENSMUSG00000057322   ribosomal protein L38
Mus musculus 102634082   60S ribosomal protein L38-like
Neospora caninum NCLIV_031440   60S ribosomal protein L38, related
Oryza sativa 4339261   Os05g0507200
Oryza sativa 4350406   Os11g0433900
Plasmodium berghei PBANKA_0918100   60S ribosomal protein L38, putative
Plasmodium falciparum PF3D7_1130100   60S ribosomal protein L38
Plasmodium knowlesi PKNH_0928000   60S ribosomal protein L38, putative
Plasmodium vivax PVX_092115   60S ribosomal protein L38, putative
Saccharomyces cerevisiae YLR325C   ribosomal 60S subunit protein L38
Schistosoma mansoni Smp_058720.1   60S ribosomal protein L38
Schmidtea mediterranea mk4.002720.06   60S ribosomal protein L38
Schmidtea mediterranea mk4.003211.01   60S ribosomal protein L38
Trypanosoma brucei gambiense Tbg972.10.4150   60S ribosomal proteins L38, putative
Trypanosoma brucei Tb927.9.2020   60S ribosomal protein L38, putative
Trypanosoma brucei Tb927.10.3280   60S ribosomal proteins L38, putative
Trypanosoma cruzi TcCLB.503881.39   ribosomal protein L38, putative
Trypanosoma cruzi TcCLB.503575.34   ribosomal protein L38, putative
Trypanosoma cruzi TcCLB.510943.26   ribosomal protein L38, putative
Trypanosoma cruzi TcCLB.508119.144   ribosomal protein L38, putative
Trypanosoma cruzi TcCLB.509351.4   ribosomal protein L38, putative
Toxoplasma gondii TGME49_231080   ribosomal protein RPL38
Theileria parva TP01_0293   60S ribosomal protein L38, putative
Trichomonas vaginalis TVAG_246730   60S ribosomal protein L38, putative
Trichomonas vaginalis TVAG_195880   60S ribosomal protein L38, putative
Trichomonas vaginalis TVAG_066460   60S ribosomal protein L38, putative
Trichomonas vaginalis TVAG_446600   conserved hypothetical protein
Trichomonas vaginalis TVAG_436870   60S ribosomal protein L38, putative
Trichomonas vaginalis TVAG_151480   60S ribosomal protein L38, putative

Essentiality

Tb927.9.2020 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.0815 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.0815 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.0815 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.0815 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.3280 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.3280 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.3280 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.3280 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C06B8.8 Caenorhabditis elegans larval arrest wormbase
CELE_C06B8.8 Caenorhabditis elegans slow growth wormbase
CELE_C06B8.8 Caenorhabditis elegans sterile wormbase
TGME49_231080 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Tb927.9.2020 (Trypanosoma brucei), 60S ribosomal protein L38, putative
Title for this comment
Comment