Detailed view for PF3D7_1000100

Basic information

TDR Targets ID: 1078
Plasmodium falciparum, erythrocyte membrane protein 1, PfEMP1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.043 | Length (AA): 2241 | MW (Da): 252331 | Paralog Number: 67

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03011   PFEMP DBL domain
PF05424   Duffy binding domain
PF15445   acidic terminal segments, variant surface antigen of PfEMP1
PF15447   N-terminal segments of PfEMP1

Gene Ontology

Mouse over links to read term descriptions.
GO:0020002   host cell plasma membrane  
GO:0050839   cell adhesion molecule binding  
GO:0046789   host cell surface receptor binding  
GO:0020035   cytoadherence to microvasculature, mediated by parasite protein  
GO:0020033   antigenic variation  
GO:0020030   infected host cell surface knob  
GO:0020013   rosetting  
GO:0019867   outer membrane  
GO:0016021   integral to membrane  
GO:0004872   receptor activity  
GO:0009405   pathogenesis  

Metabolic Pathways

Malaria (KEGG)

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
102 760 1zro (A) 8 593 17.00 0 1 -0.01 1.39
16 750 2yk0 (A) 19 693 30.00 0 1 0.511179 0.31
521 705 4v3e (A) 497 637 43.00 0.0000000035 0.57 0.130552 -0.11
526 705 4v3d (A) 504 639 40.00 0 1 0.285321 -0.35
630 806 3c64 (A) 6 165 49.00 0 1 0.489983 -0.41
697 886 4tql (A) 14 221 24.00 0.4 0.2 0.310784 -0.66
1461 1681 4v3e (A) 498 713 24.00 0 1 0.299817 -0.37
1892 1949 3s6l (A) 33 90 34.00 0.92 1 0.580081 -1.3
1901 1946 3s6l (A) 28 73 41.00 0.54 1 0.761527 -2.41
2051 2132 2lkl (A) 2 81 53.00 0.0000000034 1 0.781791 -1.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 2XU0:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2YK0:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3C64:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile merozoite, early ring. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile sporozoite, early schizont, early trophozoite, late ring, late schizont, Ring. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, gametocyte, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Sporozoite, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_128193)

Species Accession Gene Product
Plasmodium falciparum PF3D7_0833500   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0600200   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0600400   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1300100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0809100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0808700   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0808600   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1373500   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0800300   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0712300   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0800200   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0800100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0100100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0712800   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0712900   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0100300   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1000100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0412400   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0412700   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0412900   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0413100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0632500   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1240300   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0632800   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1240400   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1240600   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0900100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0711700   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0712000   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1300800   erythrocyte membrane protein 1-like
Plasmodium falciparum PF3D7_0712400   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0712600   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0732800   erythrocyte membrane protein 1 (PfEMP1), exon 2
Plasmodium falciparum PF3D7_1219300   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0600600   erythrocyte membrane protein 1 (PfEMP1), exon 2
Plasmodium falciparum PF3D7_0420700   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0420900   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0421100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1035700   duffy binding-like merozoite surface protein
Plasmodium falciparum PF3D7_0421300   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0221800   hypothetical protein
Plasmodium falciparum PF3D7_0324900   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0223300   erythrocyte membrane protein 1 (PfEMP1), exon 2
Plasmodium falciparum PF3D7_0223500   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0617400   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0300100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0937600   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0937800   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0425800   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1200100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1200400   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0426000   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1200600   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0500100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1150400   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0400100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0400400   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0700100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1041300   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0115700   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0200100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0200300   erythrocyte membrane protein 1 (PfEMP1), exon 2
Plasmodium falciparum PF3D7_1300300   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1255200   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1100100   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1100200   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_1240900   erythrocyte membrane protein 1, PfEMP1
Plasmodium falciparum PF3D7_0733000   erythrocyte membrane protein 1, PfEMP1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1000100 (Plasmodium falciparum), erythrocyte membrane protein 1, PfEMP1
Title for this comment
Comment