Detailed view for PF3D7_1000500

Basic information

TDR Targets ID: 1082
Plasmodium falciparum, rifin
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.7424 | Length (AA): 369 | MW (Da): 40963 | Paralog Number: 156

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02009   Rifin

Gene Ontology

Mouse over links to read term descriptions.
GO:0020033   antigenic variation  
GO:0020002   host cell plasma membrane  
GO:0003674   molecular_function  

Metabolic Pathways

Malaria (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
53 137 4tql (A) 95 185 28.00 0.18 0.08 0.396852 -0.28
165 321 4edp (A) 155 317 29.00 0.73 0.53 0.445874 1.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 32 hs, Oocyst, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile merozoite, sporozoite, early ring, early trophozoite, late ring, late schizont. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 40 hs, gametocyte, early schizont. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 48 hs, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_126825)

Species Accession Gene Product
Plasmodium falciparum PF3D7_0532900   rifin
Plasmodium falciparum PF3D7_0833400   rifin
Plasmodium falciparum PF3D7_0833200   rifin
Plasmodium falciparum PF3D7_0833100   rifin
Plasmodium falciparum PF3D7_0600300   rifin
Plasmodium falciparum PF3D7_0833000   rifin
Plasmodium falciparum PF3D7_0600500   rifin
Plasmodium falciparum PF3D7_0832800   rifin
Plasmodium falciparum PF3D7_0600700   rifin
Plasmodium falciparum PF3D7_0832500   rifin
Plasmodium falciparum PF3D7_0808900   rifin
Plasmodium falciparum PF3D7_0808800   rifin
Plasmodium falciparum PF3D7_1479400   rifin
Plasmodium falciparum PF3D7_1479600   rifin
Plasmodium falciparum PF3D7_1479700   rifin
Plasmodium falciparum PF3D7_1479800   rifin
Plasmodium falciparum PF3D7_1480000   rifin
Plasmodium falciparum PF3D7_1300700   rifin
Plasmodium falciparum PF3D7_1400200   rifin
Plasmodium falciparum PF3D7_1400300   rifin
Plasmodium falciparum PF3D7_0701800   rifin
Plasmodium falciparum PF3D7_1400400   rifin
Plasmodium falciparum PF3D7_1400500   rifin
Plasmodium falciparum PF3D7_1400600   rifin
Plasmodium falciparum PF3D7_1400800   rifin
Plasmodium falciparum PF3D7_0800500   rifin
Plasmodium falciparum PF3D7_0937700   rifin
Plasmodium falciparum PF3D7_0100200   rifin
Plasmodium falciparum PF3D7_0713000   rifin
Plasmodium falciparum PF3D7_0100400   rifin
Plasmodium falciparum PF3D7_1000200   rifin
Plasmodium falciparum PF3D7_1000300   rifin
Plasmodium falciparum PF3D7_0100600   rifin
Plasmodium falciparum PF3D7_1000400   rifin
Plasmodium falciparum PF3D7_1000500   rifin
Plasmodium falciparum PF3D7_0100800   rifin
Plasmodium falciparum PF3D7_1000600   rifin
Plasmodium falciparum PF3D7_0100900   rifin
Plasmodium falciparum PF3D7_1372600   rifin
Plasmodium falciparum PF3D7_0101000   rifin
Plasmodium falciparum PF3D7_0632000   rifin
Plasmodium falciparum PF3D7_1372700   rifin
Plasmodium falciparum PF3D7_0632100   rifin
Plasmodium falciparum PF3D7_0413200   rifin
Plasmodium falciparum PF3D7_0632200   rifin
Plasmodium falciparum PF3D7_0413300   rifin
Plasmodium falciparum PF3D7_0632300   rifin
Plasmodium falciparum PF3D7_0631800   rifin
Plasmodium falciparum PF3D7_0632400   rifin
Plasmodium falciparum PF3D7_1373000   rifin
Plasmodium falciparum PF3D7_0101600   rifin
Plasmodium falciparum PF3D7_1373100   rifin
Plasmodium falciparum PF3D7_0632700   rifin
Plasmodium falciparum PF3D7_0101900   rifin
Plasmodium falciparum PF3D7_1373300   rifin
Plasmodium falciparum PF3D7_1373400   rifin
Plasmodium falciparum PF3D7_0900200   rifin
Plasmodium falciparum PF3D7_0900300   rifin
Plasmodium falciparum PF3D7_0900400   rifin
Plasmodium falciparum PF3D7_0900500   rifin
Plasmodium falciparum PF3D7_0900600   rifin
Plasmodium falciparum PF3D7_0900700   rifin
Plasmodium falciparum PF3D7_0901000   rifin
Plasmodium falciparum PF3D7_0901100   rifin
Plasmodium falciparum PF3D7_0901300   rifin
Plasmodium falciparum PF3D7_0901400   rifin
Plasmodium falciparum PF3D7_0901500   rifin
Plasmodium falciparum PF3D7_0800400   rifin
Plasmodium falciparum PF3D7_1300200   rifin
Plasmodium falciparum PF3D7_0421200   rifin
Plasmodium falciparum PF3D7_0324400   rifin
Plasmodium falciparum PF3D7_0324500   rifin
Plasmodium falciparum PF3D7_0222500   rifin
Plasmodium falciparum PF3D7_0222600   rifin
Plasmodium falciparum PF3D7_0732200   rifin
Plasmodium falciparum PF3D7_0222700   rifin
Plasmodium falciparum PF3D7_0324800   rifin
Plasmodium falciparum PF3D7_0732400   rifin
Plasmodium falciparum PF3D7_0732700   rifin
Plasmodium falciparum PF3D7_0732900   rifin
Plasmodium falciparum PF3D7_0223100   rifin
Plasmodium falciparum PF3D7_0223200   rifin
Plasmodium falciparum PF3D7_0223400   rifin
Plasmodium falciparum PF3D7_0300200   rifin
Plasmodium falciparum PF3D7_0617700   rifin
Plasmodium falciparum PF3D7_0937300   rifin
Plasmodium falciparum PF3D7_0300500   rifin
Plasmodium falciparum PF3D7_0937400   rifin
Plasmodium falciparum PF3D7_0300700   rifin
Plasmodium falciparum PF3D7_0937500   rifin
Plasmodium falciparum PF3D7_0300800   rifin
Plasmodium falciparum PF3D7_1200200   rifin
Plasmodium falciparum PF3D7_1040000   rifin
Plasmodium falciparum PF3D7_0425700   rifin
Plasmodium falciparum PF3D7_1200300   rifin
Plasmodium falciparum PF3D7_1040100   rifin
Plasmodium falciparum PF3D7_1149800   rifin
Plasmodium falciparum PF3D7_0114700   rifin
Plasmodium falciparum PF3D7_0425900   rifin
Plasmodium falciparum PF3D7_1200500   rifin
Plasmodium falciparum PF3D7_1040300   rifin
Plasmodium falciparum PF3D7_1150000   rifin
Plasmodium falciparum PF3D7_1040400   rifin
Plasmodium falciparum PF3D7_1040500   rifin
Plasmodium falciparum PF3D7_1150200   rifin
Plasmodium falciparum PF3D7_1150300   rifin
Plasmodium falciparum PF3D7_1253700   rifin
Plasmodium falciparum PF3D7_0700500   rifin
Plasmodium falciparum PF3D7_1040700   rifin
Plasmodium falciparum PF3D7_1040800   rifin
Plasmodium falciparum PF3D7_0115200   rifin
Plasmodium falciparum PF3D7_0400300   rifin
Plasmodium falciparum PF3D7_0500400   rifin
Plasmodium falciparum PF3D7_0700300   rifin
Plasmodium falciparum PF3D7_1040900   rifin
Plasmodium falciparum PF3D7_0115300   rifin
Plasmodium falciparum PF3D7_0500500   rifin
Plasmodium falciparum PF3D7_0700200   rifin
Plasmodium falciparum PF3D7_1041000   rifin
Plasmodium falciparum PF3D7_0400500   rifin
Plasmodium falciparum PF3D7_1254000   rifin
Plasmodium falciparum PF3D7_1041100   rifin
Plasmodium falciparum PF3D7_0400700   rifin
Plasmodium falciparum PF3D7_1041200   rifin
Plasmodium falciparum PF3D7_0115600   rifin
Plasmodium falciparum PF3D7_1254200   rifin
Plasmodium falciparum PF3D7_0400900   rifin
Plasmodium falciparum PF3D7_0401000   rifin
Plasmodium falciparum PF3D7_1254400   rifin
Plasmodium falciparum PF3D7_1101100   rifin
Plasmodium falciparum PF3D7_0200200   rifin
Plasmodium falciparum PF3D7_0401200   rifin
Plasmodium falciparum PF3D7_1254500   rifin
Plasmodium falciparum PF3D7_0401300   rifin
Plasmodium falciparum PF3D7_0401400   rifin
Plasmodium falciparum PF3D7_1254700   rifin
Plasmodium falciparum PF3D7_0200500   rifin
Plasmodium falciparum PF3D7_1254800   rifin
Plasmodium falciparum PF3D7_0200600   rifin
Plasmodium falciparum PF3D7_0401600   rifin
Plasmodium falciparum PF3D7_0200700   rifin
Plasmodium falciparum PF3D7_1255000   rifin
Plasmodium falciparum PF3D7_1255100   rifin
Plasmodium falciparum PF3D7_1300400   rifin
Plasmodium falciparum PF3D7_0201000   rifin
Plasmodium falciparum PF3D7_1300500   rifin
Plasmodium falciparum PF3D7_1300600   rifin
Plasmodium falciparum PF3D7_0201200   rifin
Plasmodium falciparum PF3D7_1100300   rifin
Plasmodium falciparum PF3D7_1100400   rifin
Plasmodium falciparum PF3D7_1100500   rifin
Plasmodium falciparum PF3D7_0701100   rifin
Plasmodium falciparum PF3D7_1101200   rifin
Plasmodium falciparum PF3D7_1101300   rifin
Plasmodium falciparum PF3D7_0732300   rifin
Plasmodium falciparum PF3D7_0732500   rifin
Plasmodium falciparum PF3D7_1040600   rifin

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1000500 (Plasmodium falciparum), rifin
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