pI: 10.5084 |
Length (AA): 248 |
MW (Da): 30051 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 12 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
20 | 97 | 1fxl (A) | 39 | 116 | 31.00 | 0.00000036 | 1 | 0.92 | -2.05 |
20 | 192 | 1cvj (A) | 11 | 178 | 23.00 | 0 | 1 | 0.96 | 0.14 |
10 | 60 | 2dgt (A) | 68 | 118 | 22.00 | 0.021 | 0.59 | 0.549045 | -0.82 |
16 | 101 | 3ucg (A) | 168 | 252 | 20.00 | 0.98 | 1 | 0.852074 | -2.25 |
17 | 46 | 1x4a (A) | 20 | 49 | 43.00 | 0.028 | 0.68 | 0.606368 | -0.05 |
18 | 248 | 3sde (A) | 80 | 302 | 15.00 | 0.74 | 0.43 | 1.11975 | -0.35 |
22 | 186 | 2cjk (A) | 161 | 316 | 21.00 | 0.0039 | 1 | 0.969023 | -0.83 |
8 | 204 | 2lyv (A) | 2 | 195 | 24.00 | 0.000000000055 | 1 | 1.21261 | -0.9 |
10 | 60 | 2dgt (A) | 68 | 118 | 22.00 | 0.16 | 0.63 | 0.546417 | -0.79 |
17 | 46 | 1x4a (A) | 20 | 49 | 43.00 | 0.23 | 0.58 | 0.599051 | -0.12 |
18 | 94 | 2mkc (A) | 9 | 85 | 22.00 | 0.0084 | 1 | 0.843308 | -2.19 |
18 | 220 | 3sde (B) | 72 | 256 | 17.00 | 0.087 | 1 | 1.036 | -0.49 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_127745)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G07350 | serine/arginine rich-like protein SR45a |
Brugia malayi | Bm1_44470 | transformer-2a3 |
Caenorhabditis elegans | CELE_C18D11.4 | Protein RSP-8, isoform B |
Cryptosporidium hominis | Chro.50251 | hypothetical protein |
Cryptosporidium parvum | cgd5_1330 | SPAC25G10.01-like RRM domain containing protein |
Dictyostelium discoideum | DDB_G0292698 | RNA recognition motif-containing protein RRM |
Dictyostelium discoideum | DDB_G0278349 | RNA recognition motif-containing protein RRM |
Drosophila melanogaster | Dmel_CG10128 | transformer 2 |
Echinococcus granulosus | EgrG_000925900 | transformer 2 protein beta |
Echinococcus granulosus | EgrG_000709100 | transformer 2 protein |
Entamoeba histolytica | EHI_183240 | RNA recognition motif domain containing protein |
Echinococcus multilocularis | EmuJ_000925900 | transformer 2 protein beta |
Echinococcus multilocularis | EmuJ_000709100 | transformer 2 protein |
Homo sapiens | 6434 | transformer 2 beta homolog (Drosophila) |
Homo sapiens | ENSG00000164548 | transformer 2 alpha homolog (Drosophila) |
Loa Loa (eye worm) | LOAG_01228 | RNA recognition domain-containing protein domain-containing protein |
Loa Loa (eye worm) | LOAG_06479 | transformer-2b6 |
Mus musculus | ENSMUSG00000029817 | transformer 2 alpha homolog (Drosophila) |
Mus musculus | 20462 | transformer 2 beta homolog (Drosophila) |
Neospora caninum | NCLIV_028940 | Transformer-2-like protein, related |
Oryza sativa | 4345455 | Os08g0385900 |
Plasmodium berghei | PBANKA_1200800 | RNA-binding protein, putative |
Plasmodium falciparum | PF3D7_1002400 | RNA-binding protein, putative |
Plasmodium knowlesi | PKNH_0801200 | RNA-binding protein, putative |
Plasmodium vivax | PVX_094315 | RNA-binding protein, putative |
Plasmodium yoelii | PY03461 | hypothetical protein |
Schistosoma japonicum | Sjp_0203200 | Splicing factor, arginine/serine-rich 10, putative |
Schistosoma japonicum | Sjp_0205950 | Splicing factor, arginine/serine-rich 10, putative |
Schistosoma mansoni | Smp_050920 | transformer-2-related |
Schistosoma mansoni | Smp_045950.2 | transformer-2-related |
Schistosoma mansoni | Smp_045950.1 | transformer-2-related |
Schistosoma mansoni | Smp_045950.3 | transformer-2-related |
Schmidtea mediterranea | mk4.009261.00 | Transformer-2 sex-determining protein |
Schmidtea mediterranea | mk4.003606.04 | Transformer-2 sex-determining protein |
Schmidtea mediterranea | mk4.004310.02 | Transformer-2 sex-determining protein |
Schmidtea mediterranea | mk4.003856.01 | |
Schmidtea mediterranea | mk4.007539.01 | Transformer-2 sex-determining protein |
Schmidtea mediterranea | mk4.007539.05 | Transformer-2 sex-determining protein |
Schmidtea mediterranea | mk4.000267.13 | Transformer-2 sex-determining protein |
Schmidtea mediterranea | mk4.005950.02 | Transformer-2 sex-determining protein |
Schmidtea mediterranea | mk4.004251.00 | Transformer-2 sex-determining protein |
Schmidtea mediterranea | mk4.005164.00 | Transformer-2 sex-determining protein |
Schmidtea mediterranea | mk4.004074.00 | |
Schmidtea mediterranea | mk4.000529.00 | Transformer-2 sex-determining protein |
Schmidtea mediterranea | mk4.000556.02 | Transformer-2 sex-determining protein |
Schmidtea mediterranea | mk4.008444.00 | Transformer-2 sex-determining protein |
Trichomonas vaginalis | TVAG_314000 | RNA-binding protein, putative |
Trichomonas vaginalis | TVAG_021720 | polyadenylate-binding protein, putative |
Trichomonas vaginalis | TVAG_475440 | RNA recognition motif (rrm) domain containing protein, putative |
Trichomonas vaginalis | TVAG_312100 | FUS-interacting serine-arginine-rich protein, putative |
Trichomonas vaginalis | TVAG_211580 | RNA binding motif protein, putative |
Trichomonas vaginalis | TVAG_430980 | nucleolar phosphoprotein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C18D11.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C18D11.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C18D11.4 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C18D11.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C18D11.4 | Caenorhabditis elegans | sterile | wormbase |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.