pI: 9.9878 |
Length (AA): 250 |
MW (Da): 27119 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Bloodstream Form. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Procyclic. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_129209)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_29005 | Ser/Thr protein phosphatase family protein |
Candida albicans | CaO19.13975 | almost identical to C terminus of CaP19.6707 located at other end of contig19-10253 |
Candida albicans | CaO19.6683 | almost identical to C terminus of CaP19.6707 located at other end of contig19-10253 |
Candida albicans | CaO19.13999 | potential phosphoesterase |
Candida albicans | CaO19.6707 | potential phosphoesterase |
Candida albicans | CaO19_6707 | hypothetical protein |
Escherichia coli | b0049 | diadenosine tetraphosphatase |
Escherichia coli | b1838 | serine/threonine-specific protein phosphatase 1 |
Leishmania braziliensis | LbrM.22.1510 | ser/thr protein phosphatase, putative |
Leishmania donovani | LdBPK_221450.1 | ser/thr protein phosphatase, putative |
Leishmania infantum | LinJ.22.1450 | ser/thr protein phosphatase, putative |
Leishmania major | LmjF.22.1600 | ser/thr protein phosphatase, putative |
Leishmania mexicana | LmxM.22.1600 | ser/thr protein phosphatase, putative |
Loa Loa (eye worm) | LOAG_12700 | hypothetical protein |
Saccharomyces cerevisiae | YNL217W | putative serine/threonine-protein phosphatase |
Trypanosoma brucei gambiense | Tbg972.6.330 | serine/threonine protein phosphatase, putative |
Trypanosoma brucei | Tb927.4.4330 | kinetoplastid-specific phospho-protein phosphatase, putative |
Trypanosoma brucei | Tb927.6.640 | ApaH-like phosphatase ALPH1 |
Trypanosoma congolense | TcIL3000_0_57160 | kinetoplastid-specific phospho-protein phosphatase, putative |
Trypanosoma cruzi | TcCLB.509211.30 | serine/threonine protein phosphatase, putative |
Trypanosoma cruzi | TcCLB.506863.80 | serine/threonine protein phosphatase, putative |
Trichomonas vaginalis | TVAG_295750 | serine/threonine protein phosphatase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.4330 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.4330 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.4330 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.4330 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.6.640 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.640 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.640 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.640 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0049 | Escherichia coli | non-essential | goodall |
b1838 | Escherichia coli | non-essential | goodall |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.