pI: 8.5695 |
Length (AA): 828 |
MW (Da): 93955 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128229)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G54910 | DEAD-box ATP-dependent RNA helicase 32 |
Babesia bovis | BBOV_II005490 | DEAD/DEAH box helicase family protein |
Brugia malayi | Bm1_14335 | DEAD/DEAH box helicase family protein |
Candida albicans | CaO19.2712 | Probable RNA helicase |
Candida albicans | CaO19.10227 | Probable RNA helicase |
Caenorhabditis elegans | CELE_Y23H5B.6 | Protein Y23H5B.6 |
Cryptosporidium hominis | Chro.60264 | DEAD/DEAH box helicase |
Cryptosporidium parvum | cgd6_2260 | Hca4p helicase DBP4 (helicase CA4). EIF4A-1-family RNA SFII helicase |
Dictyostelium discoideum | DDB_G0284017 | DEAD/DEAH box helicase |
Drosophila melanogaster | Dmel_CG5800 | CG5800 gene product from transcript CG5800-RA |
Echinococcus granulosus | EgrG_001058400 | ATP dependent RNA helicase DDX10 |
Entamoeba histolytica | EHI_119620 | DEAD/DEAH box helicase, putative |
Echinococcus multilocularis | EmuJ_001058400 | ATP dependent RNA helicase DDX10 |
Homo sapiens | ENSG00000178105 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 |
Leishmania braziliensis | LbrM.28.1410 | ATP-dependent RNA helicase, putative |
Leishmania donovani | LdBPK_281420.1 | ATP-dependent RNA helicase, putative |
Leishmania infantum | LinJ.28.1420 | ATP-dependent RNA helicase, putative |
Leishmania major | LmjF.28.1310 | ATP-dependent RNA helicase, putative |
Leishmania mexicana | LmxM.28.1310 | ATP-dependent RNA helicase, putative |
Loa Loa (eye worm) | LOAG_00217 | hypothetical protein |
Mus musculus | ENSMUSG00000053289 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 |
Neospora caninum | NCLIV_018600 | DEAD/DEAH box helicase, putative |
Oryza sativa | 4343385 | Os07g0517000 |
Onchocerca volvulus | OVOC11857 |
|
Plasmodium berghei | PBANKA_1024300 | ATP-dependent RNA helicase DBP4, putative |
Plasmodium falciparum | PF3D7_1418900 | ATP-dependent RNA helicase DBP4, putative |
Plasmodium knowlesi | PKNH_1339100 | ATP-dependent RNA helicase DBP4, putative |
Plasmodium vivax | PVX_085535 | DEAD/DEAH box ATP-dependent RNA helicase, putative |
Plasmodium yoelii | PY06632 | RNA helicase, putative |
Saccharomyces cerevisiae | YJL033W | RNA-dependent ATPase HCA4 |
Schistosoma japonicum | Sjp_0083690 | ko:K01529 RNA Helicase [EC:3.6.1.-], putative |
Schmidtea mediterranea | mk4.001026.08 | |
Trypanosoma brucei gambiense | Tbg972.5.5770 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma brucei | Tb927.5.4270 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma congolense | TcIL3000_5_4890 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma cruzi | TcCLB.510351.40 | ATP-dependent RNA helicase, putative |
Trypanosoma cruzi | TcCLB.507601.140 | ATP-dependent RNA helicase, putative |
Toxoplasma gondii | TGME49_244000 | DEAD/DEAH box helicase domain-containing protein |
Theileria parva | TP02_0498 | ATP-dependent RNA helicase, putative |
Trichomonas vaginalis | TVAG_009310 | DEAD box ATP-dependent RNA helicase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.4270 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.4270 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.4270 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.4270 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y23H5B.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y23H5B.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y23H5B.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y23H5B.6 | Caenorhabditis elegans | sterile | wormbase |
YJL033W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1024300 | Plasmodium berghei | Essential | plasmo |
TGME49_244000 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.