Detailed view for Tb927.9.13820

Basic information

TDR Targets ID: 11226
Trypanosoma brucei, kinetoplastid membrane protein 11-3
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.4928 | Length (AA): 92 | MW (Da): 11077 | Paralog Number: 5

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03037   Kinetoplastid membrane protein 11

Gene Ontology

Mouse over links to read term descriptions.
GO:0008284   positive regulation of cell proliferation  
GO:0006952   defense response  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 85 4tql (A) 59 148 28.00 0.72 0.09 1.09001 -0.14
1 80 4uos (A) 12 91 28.00 0.06 1 1.39167 -1.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 5Y70:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_135220)

Species Accession Gene Product
Leishmania braziliensis LbrM.34.2140   kinetoplastid membrane protein-11
Leishmania braziliensis LbrM.34.2160   kinetoplastid membrane protein-11
Leishmania braziliensis LbrM.34.2150   kinetoplastid membrane protein-11
Leishmania donovani LdBPK_352260.1   kinetoplastid membrane protein-11
Leishmania infantum LinJ.35.2260   kinetoplastid membrane protein-11
Leishmania infantum LinJ.35.2270   kinetoplastid membrane protein-11
Leishmania major LmjF.35.2220   kinetoplastid membrane protein-11
Leishmania major LmjF.35.2210   kinetoplastid membrane protein-11
Leishmania mexicana LmxM.34.2221   kinetoplastid membrane protein-11
Trypanosoma brucei gambiense Tbg972.9.8650   kinetoplastid membrane protein KMP-11
Trypanosoma brucei gambiense Tbg972.9.8640   kinetoplastid membrane protein KMP-11
Trypanosoma brucei gambiense Tbg972.9.8660   kinetoplastid membrane protein KMP-11
Trypanosoma brucei gambiense Tbg972.9.8670   kinetoplastid membrane protein KMP-11
Trypanosoma brucei Tb927.9.13920   kinetoplastid membrane protein 11-1
Trypanosoma brucei Tb927.9.13795   kinetoplastid membrane protein 11-4
Trypanosoma brucei Tb427tmp.211.4512   kinetoplastid membrane protein KMP-11
Trypanosoma brucei Tb927.9.13860   kinetoplastid membrane protein 11-2
Trypanosoma brucei Tb927.9.13785   kinetoplastid membrane protein 11-5
Trypanosoma brucei Tb927.9.13820   kinetoplastid membrane protein 11-3
Trypanosoma cruzi TcCLB.508413.84   kinetoplastid membrane protein 11
Trypanosoma cruzi TcCLB.510755.98   kinetoplastid membrane protein 11
Trypanosoma cruzi TcCLB.510755.89   kinetoplastid membrane protein 11
Trypanosoma cruzi TcCLB.508413.68   kinetoplastid membrane protein 11
Trypanosoma cruzi TcCLB.508413.76   kinetoplastid membrane protein 11

Essentiality

Tb927.9.13820 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.4511 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.4511 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.4511 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.4511 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Tb927.9.13820 (Trypanosoma brucei), kinetoplastid membrane protein 11-3
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