pI: 10.0831 |
Length (AA): 151 |
MW (Da): 16706 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127221)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G23410 | 40S ribosomal protein S27a-1 |
Arabidopsis thaliana | AT2G47110 | ubiquitin-40S ribosomal protein S27a-2 |
Arabidopsis thaliana | AT3G62250 | ubiquitin-40S ribosomal protein S27a-3 |
Babesia bovis | BBOV_III008500 | ribosomal protein S27a family protein |
Brugia malayi | Bm1_09050 | ubiquitin |
Candida albicans | CaO19.10599 | ubiquitin-ribosomal protein fusion that gives rise to cytoplasmic ribosomal small subunit protein S27a |
Candida albicans | CaO19.3087 | ubiquitin-ribosomal protein fusion that gives rise to cytoplasmic ribosomal small subunit protein S27a |
Caenorhabditis elegans | CELE_H06I04.4 | Protein UBL-1, isoform A |
Cryptosporidium hominis | Chro.40350 | ubiquitin |
Cryptosporidium parvum | cgd4_3080 | ribosomal protein S27a, ubiquitin plus zincribbon, UB13p |
Dictyostelium discoideum | DDB_G0276765 | ubiquitin/ribosomal protein S27a fusion protein |
Drosophila melanogaster | Dmel_CG5271 | Ribosomal protein S27A |
Echinococcus granulosus | EgrG_000785600 | ubiquitin 40S ribosomal protein S27a |
Entamoeba histolytica | EHI_036530 | 40S ribosomal protein S27a, putative |
Echinococcus multilocularis | EmuJ_000785600 | ubiquitin 40S ribosomal protein S27a |
Giardia lamblia | GL50803_16298 | Hypothetical protein |
Homo sapiens | ENSG00000143947 | ribosomal protein S27a |
Leishmania braziliensis | LbrM.35.0720 | ubiquitin/ribosomal protein S27a, putative |
Leishmania braziliensis | LbrM.14.1440 | ubiquitin/ribosomal protein S27a, putative |
Leishmania donovani | LdBPK_360660.1 | ubiquitin/ribosomal protein S27a, putative |
Leishmania infantum | LinJ.36.0660 | ubiquitin/ribosomal protein S27a, putative |
Leishmania infantum | LinJ.14.1350 | ubiquitin/ribosomal protein S27a, putative |
Leishmania major | LmjF.14.1270 | ubiquitin/ribosomal protein S27a, putative |
Leishmania major | LmjF.36.0600 | ubiquitin/ribosomal protein S27a, putative |
Leishmania mexicana | LmxM.36.0600 | ubiquitin/ribosomal protein S27a, putative |
Leishmania mexicana | LmxM.14.1270 | ubiquitin/ribosomal protein S27a, putative |
Loa Loa (eye worm) | LOAG_04017 | ubiquitin |
Mus musculus | ENSMUSG00000020460 | ribosomal protein S27A |
Neospora caninum | NCLIV_062890 | hypothetical protein |
Oryza sativa | 4326977 | Os01g0328400 |
Oryza sativa | 4337883 | Os05g0160200 |
Plasmodium berghei | PBANKA_1039400 | ubiquitin-40S ribosomal protein S27a, putative |
Plasmodium falciparum | PF3D7_1402500 | ubiquitin-40S ribosomal protein S27a, putative |
Plasmodium knowlesi | PKNH_1355500 | ubiquitin-40S ribosomal protein S27a, putative |
Plasmodium vivax | PVX_086305 | ubiquitin-40S ribosomal protein S27a, putative |
Plasmodium yoelii | PY03337 | ubiquitin |
Plasmodium yoelii | PY00122 | ubiquitin c-terminal extension protein UBIcep86 |
Saccharomyces cerevisiae | YLR167W | ubiquitin-ribosomal 40S subunit protein S31 fusion protein |
Schistosoma japonicum | Sjp_0209330 | 40S ribosomal protein S27a, putative |
Schistosoma mansoni | Smp_017280 | ubiquitin |
Schmidtea mediterranea | mk4.000756.01 | Putative ubiquitin |
Schmidtea mediterranea | mk4.005119.00 | Ubiquitin-40S ribosomal protein S27a |
Trypanosoma brucei gambiense | Tbg972.7.4100 | ubiquitin/ribosomal protein S27a, putative |
Trypanosoma brucei gambiense | Tbg972.10.6090 | ubiquitin/ribosomal protein S27a, putative |
Trypanosoma brucei | Tb927.7.3680 | ubiquitin/ribosomal protein S27a, putative |
Trypanosoma brucei | Tb927.10.5030 | ubiquitin/ribosomal protein S27a, putative |
Trypanosoma congolense | TcIL3000_7_2940 | ubiquitin/ribosomal protein S27a, putative |
Trypanosoma congolense | TcIL3000_10_4210 | ubiquitin/ribosomal protein S27a, putative |
Trypanosoma cruzi | TcCLB.510409.39 | ubiquitin/ribosomal protein S27a, putative |
Trypanosoma cruzi | TcCLB.509937.100 | ubiquitin/ribosomal protein S27a, putative |
Trypanosoma cruzi | TcCLB.508661.20 | ubiquitin/ribosomal protein S27a, putative |
Trypanosoma cruzi | TcCLB.510293.40 | ubiquitin/ribosomal protein S27a, putative |
Toxoplasma gondii | TGME49_245620 | ribosomal-ubiquitin protein RPS27A |
Theileria parva | TP04_0752 | hypothetical protein |
Trichomonas vaginalis | TVAG_133150 | ubiquitin, putative |
Trichomonas vaginalis | TVAG_055640 | ubiquitin, putative |
Trichomonas vaginalis | TVAG_452780 | ubiquitin, putative |
Trichomonas vaginalis | TVAG_478140 | ubiquitin, putative |
Trichomonas vaginalis | TVAG_031870 | ubiquitin, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.3680 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.3680 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.3680 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.3680 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.5030 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.5030 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.5030 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.5030 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_H06I04.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_H06I04.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_H06I04.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_H06I04.4 | Caenorhabditis elegans | sterile | wormbase |
YLR167W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1039400 | Plasmodium berghei | Essential | plasmo |
TGME49_245620 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.