pI: 5.567 |
Length (AA): 235 |
MW (Da): 27371 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
18 | 234 | 5j1i (A) | 1095 | 1307 | 15.00 | 0 | 0.28 | 1.0393 | -0.19 |
52 | 234 | 4uos (A) | 3 | 182 | 10.00 | 0.086 | 0.03 | 0.982723 | -1.49 |
77 | 211 | 5f4y (A) | 1442 | 1576 | 16.00 | 0 | 0.79 | 0.648368 | -0.13 |
140 | 212 | 5hmo (A) | 808 | 888 | 37.00 | 0.89 | 0.11 | 0.599138 | -0.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_129970)
Species | Accession | Gene Product |
---|---|---|
Caenorhabditis elegans | CELE_F41G4.1 | Protein DYLA-1 |
Drosophila melanogaster | Dmel_CG6971 | CG6971 gene product from transcript CG6971-RA |
Echinococcus granulosus | EgrG_001175700 | dynein light chain |
Echinococcus granulosus | EgrG_000438100 | dynein light chain |
Echinococcus granulosus | EgrG_000518100 | dynein light chain |
Echinococcus multilocularis | EmuJ_000438100 | dynein light chain |
Echinococcus multilocularis | EmuJ_000518100 | dynein light chain |
Echinococcus multilocularis | EmuJ_001175700 | dynein light chain |
Giardia lamblia | GL50803_13273 | Dynein light intermediate chain |
Homo sapiens | ENSG00000163879 | dynein, axonemal, light intermediate chain 1 |
Leishmania braziliensis | LbrM.20.5370 | dynein arm light chain, putative |
Leishmania donovani | LdBPK_240860.1 | dynein arm light chain, putative |
Leishmania infantum | LinJ.24.0860 | dynein arm light chain, putative |
Leishmania major | LmjF.24.0840 | dynein arm light chain, putative |
Leishmania mexicana | LmxM.24.0840 | dynein arm light chain, putative |
Mus musculus | ENSMUSG00000042707 | dynein, axonemal, light intermediate polypeptide 1 |
Neospora caninum | NCLIV_066070 | 33 kda inner dynein arm light chain, putative |
Schistosoma japonicum | Sjp_0007390 | ko:K10410 dynein light intermediate chain, axonemal, putative |
Schistosoma mansoni | Smp_162140 | hypothetical protein |
Schmidtea mediterranea | mk4.012256.00 | Putative inner dynein arm light chain, axonemal |
Schmidtea mediterranea | mk4.005147.00 | Axonemal dynein light intermediate polypeptide 1 |
Schmidtea mediterranea | mk4.001191.07 | |
Schmidtea mediterranea | mk4.006911.00 | Putative inner dynein arm light chain, axonemal |
Schmidtea mediterranea | mk4.000456.11 | |
Schmidtea mediterranea | mk4.001191.08 | Axonemal dynein light intermediate polypeptide 1 |
Schmidtea mediterranea | mk4.000204.20 | Axonemal dynein light intermediate polypeptide 1 |
Trypanosoma brucei gambiense | Tbg972.11.6220 | dynein arm light chain, axonemal, putative |
Trypanosoma brucei | Tb927.11.5510 | dynein light chain p28, axonemal, putative |
Trypanosoma congolense | TcIL3000_0_33740 | dynein light chain p28, axonemal, putative |
Trypanosoma congolense | TcIL3000.11.5800 | dynein arm light chain, axonemal, putative |
Trypanosoma cruzi | TcCLB.508647.210 | dynein arm light chain, putative |
Toxoplasma gondii | TGME49_249960 | inner dynein arm light chain, putative |
Trichomonas vaginalis | TVAG_253750 | axonemal inner arm dynein light chain, putative |
Trichomonas vaginalis | TVAG_448610 | axonemal inner arm dynein light chain, putative |
Trichomonas vaginalis | TVAG_240770 | axonemal inner arm dynein light chain, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.3200 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.3200 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.3200 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.3200 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_249960 | Toxoplasma gondii | Probably non-essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.