pI: 8.1469 |
Length (AA): 383 |
MW (Da): 41143 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
26 | 102 | 1ghj (A) | 2 | 78 | 45.00 | 0.00000000018 | 1 | 0.765844 | -0.23 |
38 | 99 | 2d5d (A) | 84 | 145 | 31.00 | 0 | 1 | 0.55838 | -0.05 |
104 | 151 | 4ke2 (A) | 148 | 195 | 25.00 | 0 | 0.2 | 0.481826 | -1.05 |
140 | 380 | 1b5s (A) | 185 | 425 | 36.00 | 0 | 1 | 1.10104 | -0.3 |
154 | 382 | 1scz (A) | 176 | 404 | 54.00 | 0 | 1 | 1.30771 | -0.78 |
179 | 379 | 4n72 (A) | 425 | 628 | 38.00 | 0 | 1 | 1.0736 | -0.87 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127362)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G26910 | Dihydrolipoamide succinyltransferase |
Arabidopsis thaliana | AT5G55070 | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1 |
Babesia bovis | BBOV_IV004840 | dihydrolipoamide succinyltransferase, putative |
Brugia malayi | Bm1_34630 | dihydrolipoamide succinyltransferase |
Brugia malayi | Bm1_34625 | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta |
Candida albicans | CaO19.13545 | Dihydrolipoamide S-succinyltransferase |
Candida albicans | CaO19.6126 | Dihydrolipoamide S-succinyltransferase |
Caenorhabditis elegans | CELE_W02F12.5 | Protein DLST-1 |
Chlamydia trachomatis | CT_055 | dihydrolipoamide succinyltransferase |
Dictyostelium discoideum | DDB_G0275029 | 2-oxoglutarate dehydrogenase E2 component |
Drosophila melanogaster | Dmel_CG5214 | CG5214 gene product from transcript CG5214-RA |
Escherichia coli | b0727 | dihydrolipoyltranssuccinase |
Echinococcus granulosus | EgrG_000851500 | dihydrolipoyllysine residue succinyltransferase |
Echinococcus multilocularis | EmuJ_000851500 | dihydrolipoyllysine residue succinyltransferase |
Homo sapiens | ENSG00000119689 | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) |
Leishmania braziliensis | LbrM.28.2620 | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative |
Leishmania donovani | LdBPK_282600.1 | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative |
Leishmania infantum | LinJ.28.2600 | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative |
Leishmania major | LmjF.28.2420 | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative |
Leishmania mexicana | LmxM.28.2420 | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative |
Loa Loa (eye worm) | LOAG_04620 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04619 | hypothetical protein |
Mycobacterium leprae | ML0861c | Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB |
Mus musculus | ENSMUSG00000004789 | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) |
Mycobacterium tuberculosis | Rv2215 | DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase |
Mycobacterium ulcerans | MUL_3575 | dihydrolipoamide acetyltransferase |
Neospora caninum | NCLIV_061040 | hypothetical protein |
Oryza sativa | 4335689 | Os04g0394200 |
Onchocerca volvulus | OVOC4905 |
|
Plasmodium berghei | PBANKA_1419100 | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative |
Plasmodium falciparum | PF3D7_1320800 | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex |
Plasmodium knowlesi | PKNH_1421400 | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative |
Plasmodium vivax | PVX_122850 | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative |
Plasmodium yoelii | PY03521 | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative |
Saccharomyces cerevisiae | YDR148C | alpha-ketoglutarate dehydrogenase KGD2 |
Schistosoma japonicum | Sjp_0112430 | ko:K00658 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide [EC2.3.1.61], putative |
Schistosoma mansoni | Smp_104330 | dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase |
Schmidtea mediterranea | mk4.000008.00 | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.11.13100 | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative |
Trypanosoma brucei | Tb927.11.11680 | 2-oxoglutarate dehydrogenase E2 component, putative |
Trypanosoma congolense | TcIL3000.11.12290 | 2-oxoglutarate dehydrogenase E2 component, putative |
Trypanosoma cruzi | TcCLB.506025.60 | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative |
Trypanosoma cruzi | TcCLB.503935.20 | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative |
Toxoplasma gondii | TGME49_219550 | dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase |
Theileria parva | TP01_0262 | dihydrolipoamide succinyltransferase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0108 | dihydrolipoamide acyltransferase E2 component |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.3550 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.3550 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.3550 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.3550 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0727 | Escherichia coli | essential | goodall |
CELE_W02F12.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_W02F12.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_W02F12.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_W02F12.5 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1419100 | Plasmodium berghei | Dispensable | plasmo |
TGME49_219550 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mycobacterium tuberculosis | DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase | Compounds | References |
1 literature reference was collected for this gene.