pI: 6.653 |
Length (AA): 951 |
MW (Da): 105344 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127538)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G18524 | DNA mismatch repair protein Msh2 |
Babesia bovis | BBOV_I003810 | DNA mismatch repair enzyme, putative |
Brugia malayi | Bm1_40840 | MutS domain III family protein |
Candida albicans | CaO19.3093 | mismatch repair |
Candida albicans | CaO19.10605 | mismatch repair |
Caenorhabditis elegans | CELE_H26D21.2 | Protein MSH-2 |
Cryptosporidium hominis | Chro.80453 | MutS 2-related |
Cryptosporidium parvum | cgd8_3950 | MutS like ABC ATpase involved in DNA repair |
Dictyostelium discoideum | DDB_G0275809 | DNA mismatch repair protein |
Drosophila melanogaster | Dmel_CG4215 | spellchecker1 |
Entamoeba histolytica | EHI_172750 | DNA mismatch repair protein Msh2, putative |
Entamoeba histolytica | EHI_123830 | DNA mismatch repair protein Msh2, putative |
Echinococcus multilocularis | EmuJ_000653700 | DNA mismatch repair protein MSH2 |
Echinococcus multilocularis | EmuJ_000653500 | DNA mismatch repair protein MSH2 |
Giardia lamblia | GL50803_113252 | Msh2-like protein |
Homo sapiens | ENSG00000095002 | mutS homolog 2 |
Leishmania braziliensis | LbrM.33.0400 | DNA mismatch repair protein, putative,MSH2 |
Leishmania donovani | LdBPK_330420.1 | DNA mismatch repair protein MSH2, putative |
Leishmania infantum | LinJ.33.0420 | DNA mismatch repair protein, putative,MSH2 |
Leishmania major | LmjF.33.0410 | DNA mismatch repair protein, putative,MSH2 |
Leishmania mexicana | LmxM.32.0410 | DNA mismatch repair protein, putative,MSH2 |
Loa Loa (eye worm) | LOAG_03335 | MutS domain III family protein |
Mus musculus | ENSMUSG00000024151 | mutS homolog 2 (E. coli) |
Neospora caninum | NCLIV_026280 | DNA mismatch repair protein mutS, related |
Oryza sativa | 4338271 | Os05g0274200 |
Plasmodium berghei | PBANKA_1017100 | DNA mismatch repair protein MSH2, putative |
Plasmodium berghei | PBANKA_0804300 | DNA mismatch repair protein MSH2 |
Plasmodium falciparum | PF3D7_1427500 | DNA mismatch repair protein MSH2, putative |
Plasmodium falciparum | PF3D7_0706700 | DNA mismatch repair protein MSH2, putative |
Plasmodium knowlesi | PKNH_1331200 | DNA mismatch repair protein MSH2, putative |
Plasmodium knowlesi | PKNH_0105200 | DNA mismatch repair protein MSH2, putative |
Plasmodium vivax | PVX_085160 | DNA mismatch repair enzyme, putative |
Plasmodium vivax | PVX_087875 | DNA mismatch repair enzyme, putative |
Plasmodium yoelii | PY01096 | MutS homolog 2-related |
Plasmodium yoelii | PY07191 | DNA mismatch repair protein msh2 |
Saccharomyces cerevisiae | YOL090W | mismatch repair ATPase MSH2 |
Schistosoma japonicum | Sjp_0071170 | DNA mismatch repair protein Msh2, putative |
Schistosoma japonicum | Sjp_0304130 | ko:K08735 DNA mismatch repair protein MSH2, putative |
Schistosoma japonicum | Sjp_0082100 | DNA mismatch repair protein Msh2, putative |
Schistosoma japonicum | Sjp_0082110 | ko:K08735 DNA mismatch repair protein MSH2, putative |
Schistosoma mansoni | Smp_169120 | hypothetical protein |
Schmidtea mediterranea | mk4.003196.03 | DNA mismatch repair protein Msh2 |
Schmidtea mediterranea | mk4.003196.04 | |
Trypanosoma brucei gambiense | Tbg972.10.13330 | DNA mismatch repair protein, putative,MSH2 |
Trypanosoma brucei | Tb927.10.11020 | DNA mismatch repair protein MSH2, putative |
Trypanosoma brucei | Tb11.v5.0547 | DNA mismatch repair protein, putative |
Trypanosoma congolense | TcIL3000_10_9220 | DNA mismatch repair protein MSH2, putative |
Trypanosoma cruzi | TcCLB.509643.80 | DNA mismatch repair protein MSH2, putative |
Trypanosoma cruzi | TcCLB.507711.320 | DNA mismatch repair protein MSH2, putative |
Toxoplasma gondii | TGME49_261000 | MutS domain V domain-containing protein |
Theileria parva | TP01_0456 | DNA mismatch repair protein MSH2, putative |
Trichomonas vaginalis | TVAG_300740 | mismatch repair protein Msh2 (mutS homolog) |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.11020 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.11020 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.11020 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.11020 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0804300 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_1017100 | Plasmodium berghei | Slow | plasmo |
TGME49_261000 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.