pI: 4.5354 |
Length (AA): 222 |
MW (Da): 24516 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127633)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G04950 | monothiol glutaredoxin-S17 |
Babesia bovis | BBOV_II007430 | thioredoxin-like protein 2 |
Babesia bovis | BBOV_II007360 | Thioredoxin-like protein 2 |
Brugia malayi | Bm1_51225 | glutaredoxin-related protein |
Candida albicans | CaO19.10241 | potential thioredoxin similar to S. cerevisiae GRX3 (YDR098C) glutaredoxin |
Candida albicans | CaO19.2727 | potential thioredoxin similar to S. cerevisiae GRX3 (YDR098C) glutaredoxin |
Caenorhabditis elegans | CELE_D2063.3 | Protein GLRX-3, isoform A |
Cryptosporidium hominis | Chro.60457 | thioredoxin-like protein |
Cryptosporidium parvum | cgd6_3970 | glutaredoxin-like protein; 2 thioredoxin folds |
Dictyostelium discoideum | DDB_G0275555 | glutaredoxin family protein |
Drosophila melanogaster | Dmel_CG6523 | CG6523 gene product from transcript CG6523-RA |
Echinococcus granulosus | EgrG_000195300 | glutaredoxin 3 |
Echinococcus multilocularis | EmuJ_000195300 | glutaredoxin 3 |
Homo sapiens | ENSG00000108010 | glutaredoxin 3 |
Leishmania braziliensis | LbrM.34.1170 | thioredoxin-like protein |
Leishmania braziliensis | LbrM.05.0310 | glutaredoxin-like protein |
Leishmania donovani | LdBPK_050320.1 | glutaredoxin-like protein |
Leishmania donovani | LdBPK_351260.1 | thioredoxin-like protein |
Leishmania infantum | LinJ.05.0320 | glutaredoxin-like protein |
Leishmania infantum | LinJ.35.1260 | thioredoxin-like protein |
Leishmania major | LmjF.05.0310 | glutaredoxin-like protein |
Leishmania major | LmjF.35.1250 | thioredoxin-like protein |
Leishmania mexicana | LmxM.05.0310 | glutaredoxin-like protein |
Leishmania mexicana | LmxM.34.1250 | thioredoxin-like protein |
Loa Loa (eye worm) | LOAG_00884 | hypothetical protein |
Mus musculus | ENSMUSG00000031068 | glutaredoxin 3 |
Neospora caninum | NCLIV_015460 | hypothetical protein |
Oryza sativa | 4349034 | Os10g0500700 |
Plasmodium berghei | PBANKA_0105500 | glutaredoxin-like protein |
Plasmodium falciparum | PF3D7_0606900 | glutaredoxin-like protein |
Plasmodium knowlesi | PKNH_1143400 | glutaredoxin-like protein |
Plasmodium vivax | PVX_113510 | glutaredoxin-like protein, putative |
Plasmodium yoelii | PY00223 | glutaredoxin-related protein |
Saccharomyces cerevisiae | YER174C | monothiol glutaredoxin GRX4 |
Saccharomyces cerevisiae | YDR098C | monothiol glutaredoxin GRX3 |
Schistosoma japonicum | Sjp_0038240 | ko:K07390 monothiol glutaredoxin, putative |
Schistosoma mansoni | Smp_006550.2 | glutaredoxin grx |
Schmidtea mediterranea | mk4.000927.01 | Glutaredoxin-3 |
Trypanosoma brucei gambiense | Tbg972.10.12710 | monothiol glutaredoxin, putative |
Trypanosoma brucei gambiense | Tbg972.5.1310 | thioredoxin-like protein |
Trypanosoma brucei | Tb927.10.10420 | monothiol glutaredoxin, putative |
Trypanosoma brucei | Tb927.5.950 | monothiol glutaredoxin, putative |
Trypanosoma congolense | TcIL3000_0_47240 | monothiol glutaredoxin, putative |
Trypanosoma congolense | TcIL3000_5_680 | monothiol glutaredoxin, putative |
Trypanosoma cruzi | TcCLB.508303.65 | thioredoxin-like protein, putative |
Trypanosoma cruzi | TcCLB.503425.20 | monothiol glutaredoxin, putative |
Trypanosoma cruzi | TcCLB.511179.100 | monothiol glutaredoxin, putative |
Toxoplasma gondii | TGME49_238070 | glutaredoxin domain-containing protein |
Theileria parva | TP02_0196 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.950 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.950 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.950 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.950 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.10420 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.10420 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.10420 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.10420 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0105500 | Plasmodium berghei | Slow | plasmo |
TGME49_238070 | Toxoplasma gondii | Essentiality uncertain | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.