Detailed view for Tb927.11.10270

Basic information

TDR Targets ID: 11606
Trypanosoma brucei, Golgi SNAP receptor complex member 1, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.123 | Length (AA): 265 | MW (Da): 30555 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12352   Snare region anchored in the vesicle membrane C-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0005484   SNAP receptor activity  
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0005801   cis-Golgi network  
GO:0005794   Golgi apparatus  
GO:0000139   Golgi membrane  
GO:0016192   vesicle-mediated transport  
GO:0006888   ER to Golgi vesicle-mediated transport  
GO:0006886   intracellular protein transport  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_128832)

Species Accession Gene Product
Arabidopsis thaliana AT2G45200   Golgi SNARE 12 protein
Brugia malayi Bm1_41440   Vesicle transport v-SNARE protein
Candida albicans CaO19.6551   similar to S. cerevisiae GOS1 (YHL031C) GOlgi SNARE protein with a C-terminal membrane anchor
Candida albicans CaO19.13904   similar to S. cerevisiae GOS1 (YHL031C) GOlgi SNARE protein with a C-terminal membrane anchor
Candida albicans CaO19_6551   hypothetical protein
Caenorhabditis elegans CELE_F08F8.8   Protein GOS-28
Dictyostelium discoideum DDB_G0283831   hypothetical protein
Drosophila melanogaster Dmel_CG7700   Golgi SNARE, 28 kDa
Echinococcus granulosus EgrG_000498600   Golgi SNAP receptor complex
Echinococcus multilocularis EmuJ_000498600   Golgi SNAP receptor complex
Homo sapiens ENSG00000108587   golgi SNAP receptor complex member 1
Leishmania braziliensis LbrM.35.4260   golgi SNARE protein-like protein
Leishmania donovani LdBPK_364220.1   Golgi SNAP receptor complex member 1, putative
Leishmania infantum LinJ.36.4220   golgi SNARE protein-like protein
Leishmania major LmjF.36.4020   Qb-SNARE protein, putative
Leishmania mexicana LmxM.36.4020   golgi SNARE protein-like protein
Loa Loa (eye worm) LOAG_01145   vesicle transport V-SNARE protein
Mus musculus ENSMUSG00000010392   golgi SNAP receptor complex member 1
Oryza sativa 4328159   Os02g0126800
Saccharomyces cerevisiae YHL031C   Gos1p
Schistosoma japonicum Sjp_0304010   ko:K08495 golgi SNAP receptor complex member 1, putative
Schistosoma mansoni Smp_077230   hypothetical protein
Schmidtea mediterranea mk4.020728.01   Golgi SNAP receptor complex member 1
Schmidtea mediterranea mk4.000453.04  
Trypanosoma brucei gambiense Tbg972.11.11530   golgi SNARE protein-like,GOLGI SNAP receptor complex member, putative
Trypanosoma brucei Tb927.11.10270   Golgi SNAP receptor complex member 1, putative
Trypanosoma congolense TcIL3000_0_42030   golgi SNARE protein-like
Trypanosoma congolense TcIL3000.11.10790   Golgi SNAP receptor complex member 1, putative
Trypanosoma cruzi TcCLB.506275.50   Golgi SNAP receptor complex member 1, putative
Trypanosoma cruzi TcCLB.510719.290   Golgi SNAP receptor complex member 1, putative
Trichomonas vaginalis TVAG_280040   conserved hypothetical protein

Essentiality

Tb927.11.10270 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.2030 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.2030 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.2030 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.2030 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.11.10270 (Trypanosoma brucei), Golgi SNAP receptor complex member 1, putative
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