Detailed view for PF3D7_1009400

Basic information

TDR Targets ID: 1167
Plasmodium falciparum, zinc finger protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.6638 | Length (AA): 362 | MW (Da): 41329 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0008270   zinc ion binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 38 1bbo () 16 54 32.00 0.000053 0.82 0.39 0.52
1 38 1bbo (A) 16 54 32.00 0.16 0.27 0.233072 1.38
13 67 1x6e (A) 13 71 36.00 0.002 0.51 0.282234 1.59
271 359 2kr0 (A) 197 285 12.00 0.47 0 0.337856 -0.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, merozoite, late ring, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile sporozoite, early ring, early schizont, early trophozoite, late schizont, late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Female Gametocyte, Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_129325)

Species Accession Gene Product
Arabidopsis thaliana AT1G30970   protein SUPPRESSOR of FRI 4
Babesia bovis BBOV_IV002940   zinc finger protein 207
Brugia malayi Bm1_08820   Zinc finger protein 207
Caenorhabditis elegans CELE_B0035.1   Protein B0035.1, isoform A
Cryptosporidium hominis Chro.10037   hypothetical protein
Cryptosporidium parvum cgd1_270   zinc finger protein
Dictyostelium discoideum DDB_G0290105   C2H2-type zinc finger-containing protein
Drosophila melanogaster Dmel_CG17912   CG17912 gene product from transcript CG17912-RF
Echinococcus granulosus EgrG_000688100   zinc finger C2H2 type
Echinococcus multilocularis EmuJ_000688100   zinc finger, C2H2 type
Homo sapiens ENSG00000010244   zinc finger protein 207
Loa Loa (eye worm) LOAG_08264   zinc finger protein
Mus musculus ENSMUSG00000017421   zinc finger protein 207
Neospora caninum NCLIV_013950   hypothetical protein
Oryza sativa 4347855   Os09g0560900
Plasmodium berghei PBANKA_1207700   zinc finger protein, putative
Plasmodium falciparum PF3D7_1009400   zinc finger protein, putative
Plasmodium knowlesi PKNH_0809100   zinc finger protein, putative
Plasmodium vivax PVX_094685   zinc finger protein, putative
Plasmodium yoelii PY02536   49 kDa zinc finger protein
Schistosoma japonicum Sjp_0107350   Zinc finger protein 207, putative
Schistosoma mansoni Smp_025560   hypothetical protein
Schmidtea mediterranea mk4.000092.19   ZNF207-1
Toxoplasma gondii TGME49_286710   zinc finger, c2h2 type domain-containing protein
Theileria parva TP01_0632   hypothetical protein, conserved
Trichomonas vaginalis TVAG_416930   conserved hypothetical protein
Trichomonas vaginalis TVAG_119110   conserved hypothetical protein

Essentiality

PF3D7_1009400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1207700 Plasmodium berghei Dispensable plasmo
TGME49_286710 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_1009400 (Plasmodium falciparum), zinc finger protein, putative
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