Detailed view for PF3D7_1010000

Basic information

TDR Targets ID: 1173
Plasmodium falciparum, ribosomal protein L43, mitochondrial, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.8002 | Length (AA): 213 | MW (Da): 25457 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05047   Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 92 1s3a (A) 16 99 18.00 0 0.69 0.72 -1.41
9 91 1s3a (A) 16 98 18.00 0 0.75 0.641471 -0.81
15 87 3kru (A) 181 261 34.00 0.83 0.6 0.526323 1.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile merozoite, sporozoite, early schizont, late trophozoite, Oocyst, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, early ring, early trophozoite, late ring, late schizont, Ring, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs. Otto TD
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_128975)

Species Accession Gene Product
Arabidopsis thaliana AT3G59650   mitochondrial ribosomal protein L51/S25/CI-B8 family protein
Babesia bovis BBOV_II004580   conserved hypothetical protein
Brugia malayi Bm1_49770   Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain containing protein
Candida albicans CaO19.5279   likely mitochondrial ribosomal protein similar to S. cerevisiae MRPL51 (YPR100W) large subunit protein (human MRP-L43)
Candida albicans CaO19.12744   likely mitochondrial ribosomal protein similar to S. cerevisiae MRPL51 (YPR100W) large subunit protein (human MRP-L43)
Caenorhabditis elegans CELE_C25A1.13   Protein MRPL-34
Dictyostelium discoideum DDB_G0283273   hypothetical protein
Drosophila melanogaster Dmel_CG5479   mitochondrial ribosomal protein L43
Echinococcus granulosus EgrG_000204900   mitochondrial ribosomal protein l43
Echinococcus multilocularis EmuJ_000204900   mitochondrial ribosomal protein l43
Homo sapiens ENSG00000055950   mitochondrial ribosomal protein L43
Loa Loa (eye worm) LOAG_08660   hypothetical protein
Mus musculus ENSMUSG00000025208   mitochondrial ribosomal protein L43
Neospora caninum NCLIV_041520   hypothetical protein, conserved
Oryza sativa 9266128   Os03g0207250
Plasmodium berghei PBANKA_1208400   ribosomal protein L43, mitochondrial, putative
Plasmodium falciparum PF3D7_1010000   ribosomal protein L43, mitochondrial, putative
Plasmodium knowlesi PKNH_0809800   ribosomal protein L43, mitochondrial, putative
Plasmodium vivax PVX_094720   ribosomal protein L43, mitochondrial, putative
Plasmodium yoelii PY04009   hypothetical protein
Saccharomyces cerevisiae YPR100W   mitochondrial 54S ribosomal protein MRPL51
Schistosoma japonicum Sjp_0214730   ko:K03946 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2, putative
Schistosoma mansoni Smp_034430.2   39S ribosomal protein L43
Toxoplasma gondii TGME49_289140   ribosomal protein l22/l43, putative
Theileria parva TP02_0297   hypothetical protein, conserved

Essentiality

PF3D7_1010000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C25A1.13 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_1208400 Plasmodium berghei Essential plasmo
TGME49_289140 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1010000 (Plasmodium falciparum), ribosomal protein L43, mitochondrial, putative
Title for this comment
Comment