pI: 6.9746 |
Length (AA): 222 |
MW (Da): 25254 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 86 | 2qyw (A) | 11 | 93 | 14.00 | 0.044 | 0.14 | 0.659174 | -1.53 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Bloodstream Form. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_131529)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G29100 | vesicle transport V-snare 13 |
Arabidopsis thaliana | AT2G35190 | novel plant SNARE 11 |
Babesia bovis | BBOV_I001720 | conserved hypothetical protein |
Cryptosporidium hominis | Chro.30485 | hypothetical protein |
Cryptosporidium parvum | cgd3_4300 | possible t-snare domain, possible transmembrane domain or GPI anchor signal at C-terminus |
Dictyostelium discoideum | DDB_G0285365 | hypothetical protein |
Drosophila melanogaster | Dmel_CG44009 | CG44009 gene product from transcript CG44009-RB |
Entamoeba histolytica | EHI_116720 | hypothetical protein |
Leishmania braziliensis | LbrM.17.0360 | Qa-SNARE protein, putative |
Leishmania donovani | LdBPK_170430.1 | Qa-SNARE protein, putative |
Leishmania infantum | LinJ.17.0430 | Qa-SNARE protein, putative |
Leishmania major | LmjF.17.0380 | Qa-SNARE protein, putative |
Leishmania mexicana | LmxM.17.0380 | hypothetical protein, conserved |
Oryza sativa | 4332931 | Os03g0369800 |
Oryza sativa | 9267986 | Os06g0715100 |
Oryza sativa | 4344040 | Os07g0637400 |
Plasmodium berghei | PBANKA_1312300 | SNARE protein, putative |
Plasmodium falciparum | PF3D7_1448600 | SNARE protein, putative |
Plasmodium knowlesi | PKNH_1233500 | SNARE protein, putative |
Plasmodium vivax | PVX_118060 | hypothetical protein, conserved |
Plasmodium yoelii | PY05111 | Arabidopsis thaliana At2g35190/T4C15.14, putative |
Trypanosoma brucei gambiense | Tbg972.7.7450 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.6440 | vesicle transport v-SNARE protein, putative |
Trypanosoma congolense | TcIL3000_7_5340 | vesicle transport v-SNARE protein, putative |
Trypanosoma cruzi | TcCLB.511321.26 | vesicle transport v-SNARE protein, putative |
Trypanosoma cruzi | TcCLB.510053.50 | vesicle transport v-SNARE protein, putative |
Toxoplasma gondii | TGME49_306640 | hypothetical protein |
Theileria parva | TP01_0526 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_446910 | Novel plant SNARE, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.6440 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.6440 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.6440 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.6440 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1312300 | Plasmodium berghei | Essential | plasmo |
TGME49_306640 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.