pI: 6.3205 |
Length (AA): 667 |
MW (Da): 75462 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
80 | 318 | 4ye6 (A) | 1 | 265 | 21.00 | 0 | 1 | 0.556775 | -0.02 |
81 | 253 | 3tl4 (X) | 3 | 174 | 24.00 | 0 | 1 | 0.571303 | -0.64 |
267 | 738 | 6aqh (A) | 12 | 495 | 17.00 | 0 | 1 | 0.808908 | 0.44 |
300 | 746 | 3m4p (A) | 11 | 451 | 49.00 | 0 | 1 | 1.1016 | -0.21 |
302 | 541 | 4ah6 (A) | 50 | 301 | 24.00 | 0.00028 | 1 | 0.462116 | 0.83 |
302 | 746 | 1x54 (A) | 3 | 434 | 36.00 | 0 | 1 | 1.00291 | -0.29 |
306 | 396 | 3dm3 (A) | 8 | 101 | 16.00 | 0 | 1 | 0.180384 | -0.82 |
315 | 379 | 5gro (A) | 15 | 77 | 32.00 | 0.085 | 1 | 0.493531 | -0.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126756)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G17300 | asparaginyl-tRNA synthetase |
Arabidopsis thaliana | AT1G70980 | asparagine--tRNA ligase |
Arabidopsis thaliana | AT5G56680 | asparaginyl-tRNA synthetase, cytoplasmic 1 |
Babesia bovis | BBOV_IV009530 | asparaginyl-tRNA synthetase, putative |
Babesia bovis | BBOV_III011270 | asparaginyl-tRNA synthetase family protein |
Brugia malayi | Bm1_36235 | Asparaginyl-tRNA synthetase, cytoplasmic |
Brugia malayi | Bm1_52355 | 60K filarial antigen - nematode |
Brugia malayi | Bm1_55920 | Asparaginyl-tRNA synthetase |
Candida albicans | CaO19.13990 | similar to S. cerevisiae YCR024C |
Candida albicans | CaO19.6698 | similar to S. cerevisiae YCR024C |
Candida albicans | CaO19.13994 | asparaginyl-tRNA synthetase |
Candida albicans | CaO19_6698 | hypothetical protein |
Candida albicans | CaO19_6702 | hypothetical protein |
Candida albicans | CaO19.6702 | asparaginyl-tRNA synthetase |
Caenorhabditis elegans | CELE_Y66D12A.23 | Protein NARS-2 |
Caenorhabditis elegans | CELE_F22D6.3 | Protein NARS-1, isoform A |
Cryptosporidium hominis | Chro.80047 | asparaginyl-tRNA synthetase |
Cryptosporidium parvum | cgd8_350 | asparaginyl-tRNA synthetase (NOB+tRNA synthase) |
Dictyostelium discoideum | DDB_G0268100 | asparagine-tRNA ligase |
Dictyostelium discoideum | DDB_G0275263 | asparagine-tRNA ligase |
Drosophila melanogaster | Dmel_CG6796 | CG6796 gene product from transcript CG6796-RA |
Drosophila melanogaster | Dmel_CG10687 | Asparaginyl-tRNA synthetase |
Escherichia coli | b0930 | asparaginyl tRNA synthetase |
Echinococcus granulosus | EgrG_002026800 | asparaginyl tRNA synthetase, cytoplasmic |
Echinococcus granulosus | EgrG_000889700 | asparaginyl tRNA synthetase |
Echinococcus granulosus | EgrG_000348600 | asparaginyl tRNA synthetase cytoplasmic |
Entamoeba histolytica | EHI_126920 | asparaginyl-tRNA synthetase, putative |
Echinococcus multilocularis | EmuJ_000348700 | asparaginyl tRNA synthetase |
Echinococcus multilocularis | EmuJ_000348300 | asparaginyl tRNA synthetase, cytoplasmic |
Echinococcus multilocularis | EmuJ_000889700 | asparaginyl tRNA synthetase |
Echinococcus multilocularis | EmuJ_000348600 | asparaginyl tRNA synthetase, cytoplasmic |
Giardia lamblia | GL50803_14375 | Asparaginyl-tRNA synthetase |
Homo sapiens | ENSG00000137513 | asparaginyl-tRNA synthetase 2, mitochondrial (putative) |
Homo sapiens | ENSG00000134440 | asparaginyl-tRNA synthetase |
Leishmania braziliensis | LbrM.20.1840 | asparaginyl-tRNA synthetase, putative |
Leishmania donovani | LdBPK_342110.1 | asparaginyl-tRNA synthetase, putative |
Leishmania infantum | LinJ.34.2110 | asparaginyl-tRNA synthetase, putative |
Leishmania major | LmjF.34.2340 | asparaginyl-tRNA synthetase, putative |
Leishmania mexicana | LmxM.33.2340 | asparaginyl-tRNA synthetase, putative |
Loa Loa (eye worm) | LOAG_08758 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08301 | 63kd antigen |
Mus musculus | ENSMUSG00000024587 | asparaginyl-tRNA synthetase |
Mus musculus | ENSMUSG00000018995 | asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) |
Neospora caninum | NCLIV_036250 | Asparaginyl-tRNA synthetase, related |
Oryza sativa | 4325717 | Os01g0372700 |
Oryza sativa | 4343250 | Os07g0485400 |
Plasmodium berghei | PBANKA_1109200 | asparagine--tRNA ligase, putative |
Plasmodium berghei | PBANKA_0308600 | asparagine--tRNA ligase, putative |
Plasmodium falciparum | PF3D7_0509600 | asparagine--tRNA ligase |
Plasmodium falciparum | PF3D7_0211800 | asparagine--tRNA ligase |
Plasmodium knowlesi | PKNH_0409400 | asparagine--tRNA ligase, putative |
Plasmodium knowlesi | PKNH_1024000 | asparagine--tRNA ligase, putative |
Plasmodium vivax | PVX_098040 | asparagine--tRNA ligase, putative |
Plasmodium vivax | PVX_002940 | asparagine--tRNA ligase, putative |
Plasmodium yoelii | PY05639 | asparaginyl-tRNA synthetase |
Plasmodium yoelii | PY02504 | asparaginyl-tRNA synthetase |
Plasmodium yoelii | PY03253 | asparaginyl-tRNA synthetase |
Saccharomyces cerevisiae | YHR019C | asparagine--tRNA ligase DED81 |
Saccharomyces cerevisiae | YCR024C | asparagine--tRNA ligase SLM5 |
Schistosoma japonicum | Sjp_0209560 | ko:K01893 asparaginyl-tRNA synthetase [EC6.1.1.22], putative |
Schistosoma japonicum | Sjp_0121910 | IPR004365,nucleic acid binding, OB-fold, tRNA/helicase-type;IPR008994,Nucleic acid-binding, OB-fold,domain-containing |
Schistosoma mansoni | Smp_169030 | aspartyl-tRNA synthetase |
Schistosoma mansoni | Smp_041450 | aspartyl-tRNA synthetase |
Schmidtea mediterranea | mk4.042846.03 | AsparagineALQ-tRNA ligase, cytoplasmic |
Schmidtea mediterranea | mk4.000202.11 | Aspartyl-tRNA synthetase, putative |
Schmidtea mediterranea | mk4.000143.03 | |
Trypanosoma brucei gambiense | Tbg972.4.2280 | asparaginyl-tRNA synthetase, putative |
Trypanosoma brucei | Tb927.4.2310 | asparaginyl-tRNA synthetase, putative |
Trypanosoma congolense | TcIL3000_4_2130 | asparaginyl-tRNA synthetase, putative |
Trypanosoma cruzi | TcCLB.506559.350 | asparaginyl-tRNA synthetase, putative |
Toxoplasma gondii | TGME49_270510 | asparaginyl-tRNA synthetase (NOB+tRNA synthase) |
Treponema pallidum | TP0609 | asparaginyl-tRNA synthetase |
Theileria parva | TP01_0818 | asparaginyl-tRNA synthetase, putative |
Theileria parva | TP02_0746 | asparaginyl-tRNA synthetase, putative |
Trichomonas vaginalis | TVAG_156640 | aspartyl/lysyl-tRNA synthetase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.2310 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.2310 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.2310 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.2310 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0930 | Escherichia coli | essential | goodall |
CELE_F22D6.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F22D6.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F22D6.3 | Caenorhabditis elegans | sterile | wormbase |
YHR019C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0308600 | Plasmodium berghei | Slow | plasmo |
PBANKA_1109200 | Plasmodium berghei | Essential | plasmo |
TGME49_270510 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.