pI: 11.1016 |
Length (AA): 63 |
MW (Da): 7406 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 47 | 3u28 (B) | 1 | 48 | 70.00 | 0 | 0.6 | 1.43583 | 0.37 |
9 | 63 | 1iuy (A) | 9 | 63 | 27.00 | 0.61 | 0.07 | 1.18182 | -0.45 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | Bloodstream Form. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Procyclic. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127952)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G20490 | nucleolar RNA binding protein NOP10 |
Babesia bovis | BBOV_IV010540 | ribosome biogeneisis subunit NOP10, putative |
Brugia malayi | Bm1_09685 | NOLA3 protein |
Caenorhabditis elegans | CELE_C25A1.6 | Protein NOLA-3 |
Cryptosporidium parvum | cgd1_530 | hypothetical protein |
Dictyostelium discoideum | DDB_G0288347 | H/ACA RNP complex subunit 3 |
Drosophila melanogaster | Dmel_CG7637 | CG7637 gene product from transcript CG7637-RA |
Echinococcus granulosus | EgrG_000535600 | H:ACA ribonucleoprotein complex subunit 3 |
Entamoeba histolytica | EHI_131470 | ribosome biogenesis protein Nop10, putative |
Echinococcus multilocularis | EmuJ_000535600 | H:ACA ribonucleoprotein complex subunit 3 |
Giardia lamblia | GL50803_8242 | Ribosome biogenesis protein Nop10 |
Homo sapiens | ENSG00000182117 | NOP10 ribonucleoprotein |
Leishmania braziliensis | LbrM.35.0430 | nuclear protein family a (nop10p), putative |
Leishmania donovani | LdBPK_360370.1 | nuclear protein family a (nop10p), putative |
Leishmania infantum | LinJ.36.0370 | nuclear protein family a (nop10p), putative |
Leishmania major | LmjF.36.0340 | nuclear protein family a (nop10p), putative |
Leishmania mexicana | LmxM.36.0340 | nuclear protein family a (nop10p), putative |
Loa Loa (eye worm) | LOAG_06322 | hypothetical protein |
Mus musculus | 102635936 | predicted gene, 33146 |
Mus musculus | 66181 | NOP10 ribonucleoprotein |
Oryza sativa | 9269830 | Os02g0618250 |
Onchocerca volvulus | OVOC1672 |
|
Plasmodium berghei | PBANKA_1011900 | H/ACA ribonucleoprotein complex subunit 3, putative |
Plasmodium falciparum | PF3D7_1433000 | H/ACA ribonucleoprotein complex subunit 3, putative |
Plasmodium knowlesi | PKNH_0419600 | H/ACA ribonucleoprotein complex subunit 3, putative |
Plasmodium vivax | PVX_084895 | H/ACA ribonucleoprotein complex subunit 3, putative |
Plasmodium yoelii | PY05263 | protein Saccharomyces cerevisiae YHR072w-a |
Saccharomyces cerevisiae | YHR072W-A | Nop10p |
Schistosoma japonicum | Sjp_0105390 | IPR007264,Nucleolar RNA-binding protein Nop10p;IPR005135,Endonuclease/exonuclease/phosphatase,domain-containing |
Schistosoma mansoni | Smp_093320 | ribosome biogenesis protein Nop10 |
Schmidtea mediterranea | mk4.000060.10 | Putative H/ACA ribonucleoprotein complex subunit 3 |
Trypanosoma brucei gambiense | Tbg972.10.5760 | nucleolar RNA-binding protein, putative |
Trypanosoma brucei | Tb927.10.4740 | nucleolar RNA-binding protein, putative |
Trypanosoma cruzi | TcCLB.510289.6 | nucleolar RNA-binding protein, putative |
Trypanosoma cruzi | TcCLB.503891.54 | nucleolar RNA-binding protein, putative |
Toxoplasma gondii | TGME49_278270 | nucleolar protein, structural component of H/ACA snoRNPs, putative |
Theileria parva | TP01_0673 | hypothetical protein |
Trichomonas vaginalis | TVAG_282120 | ribosome biogenesis protein nop10, putative |
Trichomonas vaginalis | TVAG_318880 | ribosome biogenesis protein nop10, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.4740 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.4740 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.4740 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.4740 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C25A1.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C25A1.6 | Caenorhabditis elegans | sterile | wormbase |
YHR072W-A | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_278270 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.