pI: 9.9519 |
Length (AA): 418 |
MW (Da): 48160 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
363 | 418 | 5wst (A) | 868 | 924 | 18.00 | 0.25 | 0.01 | 0.414571 | -1.29 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128453)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G46470 | inner membrane OXA1-like protein |
Arabidopsis thaliana | AT5G62050 | mitochondrial inner membrane protein OXA1 |
Babesia bovis | BBOV_IV002440 | cytochrome oxidase biogenesis protein 1-1 (OXA1), putative |
Brugia malayi | Bm1_54550 | 60Kd inner membrane protein |
Brugia malayi | Bm1_54555 | 60Kd inner membrane protein |
Candida albicans | CaO19_6565 | hypothetical protein |
Candida albicans | CaO19.6565 | assembly of cytochrome oxidase, ATP synthase |
Candida albicans | CaO19.13918 | assembly of cytochrome oxidase, ATP synthase |
Caenorhabditis elegans | CELE_C01A2.3 | Protein C01A2.3 |
Dictyostelium discoideum | DDB_G0284883 | hypothetical protein |
Dictyostelium discoideum | DDB_G0281171 | hypothetical protein |
Drosophila melanogaster | Dmel_CG6404 | CG6404 gene product from transcript CG6404-RA |
Echinococcus granulosus | EgrG_000251800 | cytochrome oxidase biogenesis protein |
Echinococcus multilocularis | EmuJ_000251800 | cytochrome oxidase biogenesis protein |
Homo sapiens | ENSG00000155463 | oxidase (cytochrome c) assembly 1-like |
Leishmania braziliensis | LbrM.11.0980 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_111170.1 | 60Kd inner membrane protein, putative |
Leishmania infantum | LinJ.11.1170 | hypothetical protein, conserved |
Leishmania major | LmjF.11.1180 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.11.1180 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04050 | 60Kd inner membrane protein |
Loa Loa (eye worm) | LOAG_04051 | hypothetical protein |
Mus musculus | ENSMUSG00000000959 | oxidase assembly 1-like |
Oryza sativa | 4349143 | Os10g0521300 |
Oryza sativa | 4331399 | Os03g0116000 |
Onchocerca volvulus | OVOC227 | Mitochondrial inner membrane protein homolog |
Plasmodium berghei | PBANKA_0702300 | mitochondrial inner membrane protein OXA1, putative |
Plasmodium falciparum | PF3D7_0828400 | mitochondrial inner membrane protein OXA1, putative |
Plasmodium knowlesi | PKNH_1322500 | mitochondrial inner membrane protein OXA1, putative |
Plasmodium vivax | PVX_088935 | mitochondrial inner membrane protein OXA1, putative |
Plasmodium yoelii | PY05780 | hypothetical protein |
Saccharomyces cerevisiae | YER154W | Oxa1p |
Schistosoma japonicum | Sjp_0215380 | ko:K03217 preprotein translocase YidC subunit, putative |
Schistosoma mansoni | Smp_161940 | cytochrome oxidase biogenesis protein (oxa1 mitochondrial) |
Schmidtea mediterranea | mk4.005590.01 | Mitochondrial inner membrane protein OXA1L |
Schmidtea mediterranea | mk4.003072.00 | Mitochondrial inner membrane protein OXA1L |
Schmidtea mediterranea | mk4.004522.01 | Mitochondrial inner membrane protein OXA1L |
Schmidtea mediterranea | mk4.004522.02 | Mitochondrial inner membrane protein OXA1L |
Schmidtea mediterranea | mk4.003739.02 | Putative cytochrome oxidase biogenesis protein |
Schmidtea mediterranea | mk4.015153.01 | Mitochondrial inner membrane protein OXA1L |
Trypanosoma brucei gambiense | Tbg972.11.6930 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.6150 | 60Kd inner membrane protein, putative |
Trypanosoma congolense | TcIL3000.11.6680 | 60Kd inner membrane protein, putative |
Trypanosoma cruzi | TcCLB.508041.50 | 60Kd inner membrane protein, putative |
Trypanosoma cruzi | TcCLB.506297.310 | 60Kd inner membrane protein, putative |
Theileria parva | TP03_0408 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.4020 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.4020 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.4020 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.4020 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C01A2.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C01A2.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C01A2.3 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_0702300 | Plasmodium berghei | Essential | plasmo |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1
1 literature reference was collected for this gene.