pI: 11.1914 |
Length (AA): 242 |
MW (Da): 27714 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
81 | 137 | 1bxy (A) | 2 | 57 | 16.00 | 0 | 0.73 | 0.561837 | -1.31 |
86 | 137 | 4wfa (W) | 6 | 57 | 23.00 | 0 | 0.99 | 0.628176 | -1.04 |
86 | 241 | 1vq8 (W) | 4 | 153 | 20.00 | 0 | 1 | 0.933928 | -0.63 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126953)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G44120 | 60S ribosomal protein L7-3 |
Arabidopsis thaliana | AT3G13580 | 60S ribosomal protein L7-4 |
Babesia bovis | BBOV_III000980 | 60S ribosomal protein L7, putative |
Brugia malayi | Bm1_24400 | 60S ribosomal protein L7 |
Caenorhabditis elegans | CELE_F53G12.10 | Protein RPL-7 |
Cryptosporidium hominis | Chro.80499 | 60S ribosomal protein L7 |
Cryptosporidium parvum | cgd8_4350 | 60S ribosomal protein L7 |
Dictyostelium discoideum | DDB_G0276441 | S60 ribosomal protein L7 |
Drosophila melanogaster | Dmel_CG4897 | Ribosomal protein L7 |
Echinococcus granulosus | EgrG_001122900 | large subunit ribosomal protein l7e |
Entamoeba histolytica | EHI_146530 | 60S ribosomal protein L7, putative |
Entamoeba histolytica | EHI_010650 | 60S ribosomal protein L7, putative |
Entamoeba histolytica | EHI_025830 | 60S ribosomal protein L7, putative |
Entamoeba histolytica | EHI_192110 | 60S ribosomal protein L7, putative |
Echinococcus multilocularis | EmuJ_001122900 | large subunit ribosomal protein l7e |
Giardia lamblia | GL50803_19436 | Ribosomal protein L7 |
Homo sapiens | ENSG00000147604 | ribosomal protein L7 |
Leishmania braziliensis | LbrM.26.0160 | 60S ribosomal protein L7, putative |
Leishmania braziliensis | LbrM.26.0170 | 60S ribosomal protein L7, putative |
Leishmania donovani | LdBPK_260160.1 | 60S ribosomal protein L7, putative |
Leishmania infantum | LinJ.26.0160 | 60S ribosomal protein L7, putative |
Leishmania infantum | LinJ.26.0150 | 60S ribosomal protein L7, putative |
Leishmania major | LmjF.26.0180 | 60S ribosomal protein L7, putative |
Leishmania major | LmjF.26.0170 | 60S ribosomal protein L7, putative |
Leishmania mexicana | LmxM.26.0180 | 60S ribosomal protein L7, putative |
Leishmania mexicana | LmxM.26.0170 | 60S ribosomal protein L7, putative |
Loa Loa (eye worm) | LOAG_05190 | 60S ribosomal protein L7 |
Mus musculus | ENSMUSG00000043716 | ribosomal protein L7 |
Neospora caninum | NCLIV_057700 | hypothetical protein |
Oryza sativa | 4345009 | Os08g0234000 |
Oryza sativa | 4336914 | Os04g0605900 |
Plasmodium berghei | PBANKA_0405500 | 60S ribosomal protein L7, putative |
Plasmodium falciparum | PF3D7_0307200 | 60S ribosomal protein L7, putative |
Plasmodium knowlesi | PKNH_0835500 | 60S ribosomal protein L7, putative |
Plasmodium vivax | PVX_119480 | 60S ribosomal protein L7, putative |
Plasmodium yoelii | PY05756 | putative 60S Ribosomal protein L7 |
Saccharomyces cerevisiae | YPL198W | ribosomal 60S subunit protein L7B |
Saccharomyces cerevisiae | YGL076C | ribosomal 60S subunit protein L7A |
Schistosoma japonicum | Sjp_0080800 | ko:K02937 large subunit ribosomal protein L7e, putative |
Schistosoma mansoni | Smp_101450 | 60S ribosomal protein L7 |
Schmidtea mediterranea | mk4.001722.05 | 60S ribosomal protein L7 |
Trypanosoma brucei gambiense | Tbg972.7.1740 | 60S ribosomal protein L7, putative |
Trypanosoma brucei gambiense | Tbg972.7.1750 | 60S ribosomal protein L7, putative |
Trypanosoma brucei | Tb927.7.1750 | 60S ribosomal protein L7, putative |
Trypanosoma brucei | Tb927.7.1740 | 60S ribosomal protein L7, putative |
Trypanosoma brucei | Tb927.7.1730 | 60S ribosomal protein L7, putative |
Trypanosoma congolense | TcIL3000_0_32580 | 60S ribosomal protein L7, putative |
Trypanosoma cruzi | TcCLB.507519.110 | 60S ribosomal protein L7, putative |
Trypanosoma cruzi | TcCLB.508207.110 | 60S ribosomal protein L7, putative |
Trypanosoma cruzi | TcCLB.508207.100 | 60S ribosomal protein L7, putative |
Toxoplasma gondii | TGME49_314810 | ribosomal protein RPL7 |
Theileria parva | TP03_0744 | 60S ribosomal protein L7, putative |
Trichomonas vaginalis | TVAG_054130 | 60S ribosomal protein L7, putative |
Trichomonas vaginalis | TVAG_159370 | 60S ribosomal protein L7, putative |
Trichomonas vaginalis | TVAG_067980 | 60S ribosomal protein L7, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.1730 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.1730 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.1730 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.7.1730 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F53G12.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F53G12.10 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F53G12.10 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F53G12.10 | Caenorhabditis elegans | sterile | wormbase |
TGME49_314810 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.