pI: 11.1814 |
Length (AA): 113 |
MW (Da): 12560 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126998)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G34555 | 40S ribosomal protein S25-3 |
Arabidopsis thaliana | AT4G39200 | 40S ribosomal protein S25-4 |
Arabidopsis thaliana | AT2G21580 | 40S ribosomal protein S25-2 |
Babesia bovis | BBOV_IV010200 | ribosomal protein S25, putative |
Brugia malayi | Bm1_52440 | 40S ribosomal protein S25 |
Candida albicans | CaO19.6663 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS25A (YGR027C) small subunit protein S25 |
Caenorhabditis elegans | CELE_K02B2.5 | Protein RPS-25 |
Cryptosporidium hominis | Chro.20119 | hypothetical protein |
Cryptosporidium parvum | cgd2_1070 | 40S ribosomal protein S25 |
Dictyostelium discoideum | DDB_G0271148 | 40S ribosomal protein S25 |
Drosophila melanogaster | Dmel_CG6684 | Ribosomal protein S25 |
Entamoeba histolytica | EHI_074800 | ribosomal protein S25, putative |
Entamoeba histolytica | EHI_177470 | ribosomal protein S25, putative |
Entamoeba histolytica | EHI_189150 | ribosomal protein S25, putative |
Giardia lamblia | GL50803_13268 | Hypothetical protein |
Homo sapiens | 6230 | ribosomal protein S25 |
Leishmania braziliensis | LbrM.20.0410 | ribosomal protein S25 |
Leishmania braziliensis | LbrM.25.1160 | ribosomal protein S25 |
Leishmania donovani | LdBPK_251220.1 | ribosomal protein S25 |
Leishmania donovani | LdBPK_340460.1 | ribosomal protein S25 |
Leishmania infantum | LinJ.34.0460 | ribosomal protein S25 |
Leishmania infantum | LinJ.25.1220 | ribosomal protein S25 |
Leishmania major | LmjF.34.0440 | ribosomal protein S25 |
Leishmania major | LmjF.25.1190 | ribosomal protein S25 |
Leishmania mexicana | LmxM.25.1190 | ribosomal protein S25 |
Leishmania mexicana | LmxM.33.0440 | ribosomal protein S25 |
Loa Loa (eye worm) | LOAG_03099 | hypothetical protein |
Mus musculus | ENSMUSG00000009927 | ribosomal protein S25 |
Mus musculus | 243302 | predicted gene 4963 |
Mus musculus | 629595 | predicted gene 6988 |
Mus musculus | 102638785 | 40S ribosomal protein S25-like |
Neospora caninum | NCLIV_031510 | hypothetical protein |
Oryza sativa | 4349810 | Os11g0153800 |
Oryza sativa | 4347899 | Os09g0568800 |
Oryza sativa | 4346314 | Os08g0559200 |
Plasmodium berghei | PBANKA_1022000 | 40S ribosomal protein S25, putative |
Plasmodium falciparum | PF3D7_1421200 | 40S ribosomal protein S25 |
Plasmodium knowlesi | PKNH_1336700 | 40S ribosomal protein S25, putative |
Plasmodium vivax | PVX_085420 | 40S ribosomal protein S25, putative |
Saccharomyces cerevisiae | YLR333C | ribosomal 40S subunit protein S25B |
Saccharomyces cerevisiae | YGR027C | ribosomal 40S subunit protein S25A |
Schistosoma japonicum | Sjp_0033940 | hypothetical protein |
Schistosoma japonicum | Sjp_0206050 | ko:K02975 small subunit ribosomal protein S25e, putative |
Schistosoma mansoni | Smp_017450 | hypothetical protein |
Schmidtea mediterranea | mk4.000089.13 | Adenylate kinase isoenzyme 1 |
Trypanosoma brucei gambiense | Tbg972.10.3540 | ribosomal protein S25, putative |
Trypanosoma brucei gambiense | Tbg972.3.1120 | ribosomal protein S25, putative |
Trypanosoma brucei | Tb927.3.1370 | 40S ribosomal protein S25, putative |
Trypanosoma brucei | Tb927.10.2840 | ribosomal protein S25, putative |
Trypanosoma congolense | TcIL3000_10_2450 | 40S ribosomal protein S25, putative |
Trypanosoma congolense | TcIL3000_3_580 | ribosomal protein S25, putative |
Trypanosoma cruzi | TcCLB.509233.190 | ribosomal protein S25, putative |
Trypanosoma cruzi | TcCLB.504105.94 | ribosomal protein S25, putative |
Toxoplasma gondii | TGME49_231140 | ribosomal protein RPS25 |
Theileria parva | TP01_0653 | 40S ribosomal protein S25, putative |
Trichomonas vaginalis | TVAG_226630 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_426530 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_111510 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_198370 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.1370 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.1370 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.1370 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.1370 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.2840 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.2840 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.2840 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.2840 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_K02B2.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K02B2.5 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_231140 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.