Detailed view for Tb927.8.4330

Basic information

TDR Targets ID: 12550
Trypanosoma brucei, small GTP-binding protein Rab11
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.6972 | Length (AA): 216 | MW (Da): 23528 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016197   endosome transport  
GO:0016191   synaptic vesicle uncoating  
GO:0012505   endomembrane system  
GO:0005768   endosome  
GO:0005622   intracellular  
GO:0005525   GTP binding  
GO:0005515   protein binding  
GO:0003924   GTPase activity  
GO:0016192   vesicle-mediated transport  
GO:0015031   protein transport  
GO:0007264   small GTPase mediated signal transduction  
GO:0007165   signal transduction  
GO:0006913   nucleocytoplasmic transport  
GO:0006886   intracellular protein transport  

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_126971)

Species Accession Gene Product
Arabidopsis thaliana AT1G16920   Ras-related protein RABA1b
Arabidopsis thaliana AT5G60860   RAB GTPase homolog A1F
Arabidopsis thaliana AT5G59150   RAB GTPase homolog A2D
Arabidopsis thaliana AT1G07410   RAB GTPase homolog A2B
Arabidopsis thaliana AT3G46830   Ras-related protein RABA2c
Arabidopsis thaliana AT2G33870   RAB GTPaselike protein A1H
Arabidopsis thaliana AT3G15060   RAB GTPase-like protein A1G
Arabidopsis thaliana AT4G18800   RAB GTPase homolog A1D
Arabidopsis thaliana AT5G45750   Ras-related protein RABA1c
Arabidopsis thaliana AT4G18430   RAB GTPase homolog A1E
Arabidopsis thaliana AT1G28550   ras-related protein RABA1i
Arabidopsis thaliana AT1G09630   RAB GTPase 11C
Babesia bovis BBOV_IV006550   ras-related protein Rab11A
Brugia malayi Bm1_56235   Ras-related protein Rab-11B
Candida albicans CaO19.2622   similar to S. cerevisiae VPT32 (YGL210W) and VPT31 (YER031C) rab family GTP binding proteins involved in trans-Golgi vesicle bud
Candida albicans CaO19.10153   similar to S. cerevisiae VPT32 (YGL210W) and VPT31 (YER031C) rab family GTP binding proteins involved in trans-Golgi vesicle bud
Caenorhabditis elegans CELE_F53G12.1   Protein RAB-11.1
Cryptosporidium parvum cgd4_320   Rab11, putative
Dictyostelium discoideum DDB_G0277101   Rab GTPase
Dictyostelium discoideum DDB_G0269238   Rab GTPase
Drosophila melanogaster Dmel_CG5771   CG5771 gene product from transcript CG5771-RA
Echinococcus granulosus EgrG_001103600   armadillo segment polarity protein
Echinococcus granulosus EgrG_000349500   rab
Entamoeba histolytica EHI_005460   Rab family GTPase
Entamoeba histolytica EHI_107250   small GTPase Rab11B
Echinococcus multilocularis EmuJ_000349500   rab
Echinococcus multilocularis EmuJ_001103600   armadillo segment polarity protein
Giardia lamblia GL50803_1695   Rab11
Homo sapiens ENSG00000185236   RAB11B, member RAS oncogene family
Homo sapiens ENSG00000103769   RAB11A, member RAS oncogene family
Leishmania braziliensis LbrM.10.1010   small GTP-binding protein Rab11, putative
Leishmania donovani LdBPK_100960.1   small GTP-binding protein Rab11, putative
Leishmania infantum LinJ.10.0960   small GTP-binding protein Rab11, putative
Leishmania major LmjF.10.0910   small GTP-binding protein Rab11, putative
Leishmania mexicana LmxM.10.0910   small GTP-binding protein Rab11, putative,Rab11 GTPase, putative
Loa Loa (eye worm) LOAG_05192   rab family protein
Mus musculus ENSMUSG00000004771   RAB11A, member RAS oncogene family
Mus musculus ENSMUSG00000077450   RAB11B, member RAS oncogene family
Neospora caninum NCLIV_041930   GE25707, related
Oryza sativa 4334746   Os03g0843100
Oryza sativa 4324856   Os01g0848700
Oryza sativa 4337555   Os05g0105100
Oryza sativa 4334619   Os03g0823700
Oryza sativa 4341266   Os06g0551400
Oryza sativa 4324623   Os01g0750000
Oryza sativa 4339324   Os05g0516800
Oryza sativa 4339623   Os05g0564400
Oryza sativa 4346744   Os09g0327100
Plasmodium berghei PBANKA_1418900   ras-related protein Rab-11A
Plasmodium falciparum PF3D7_1320600   ras-related protein Rab-11A
Plasmodium knowlesi PKNH_1421200   ras-related protein Rab-11A, putative
Plasmodium vivax PVX_122840   ras-related protein Rab-11A, putative
Plasmodium yoelii PY07141   small GTPase rab11-related
Saccharomyces cerevisiae YER031C   Rab family GTPase YPT31
Saccharomyces cerevisiae YGL210W   Rab family GTPase YPT32
Schistosoma japonicum Sjp_0092360   IPR000225,Armadillo,domain-containing
Schistosoma japonicum Sjp_0053640   Catenin beta, putative
Schistosoma japonicum Sjp_0082770   Ras-related protein Rab-11A, putative
Schistosoma japonicum Sjp_0057820   Ras-related protein Rab-11B, putative
Schistosoma japonicum Sjp_0053650   ko:K07976 Rab family, other, putative
Schistosoma japonicum Sjp_0306660   expressed protein
Schistosoma japonicum Sjp_0124840   expressed protein
Schistosoma mansoni Smp_005670   rab11
Schistosoma mansoni Smp_104310   rab11
Schistosoma mansoni Smp_173990   rab11
Schmidtea mediterranea mk4.018375.01  
Schmidtea mediterranea mk4.001733.01   Ras-related protein Rab-25
Schmidtea mediterranea mk4.000248.00   Rab-11B
Schmidtea mediterranea mk4.023113.00   Ras-related protein Rab-25
Schmidtea mediterranea mk4.002841.00   Ras-related protein Rab-25
Trypanosoma brucei gambiense Tbg972.8.4080   small GTP-binding protein Rab11, putative,Rab11A GTPase
Trypanosoma brucei Tb927.8.4330   small GTP-binding protein Rab11
Trypanosoma congolense TcIL3000_8_4030   small GTP-binding protein Rab11, putative
Trypanosoma cruzi TcCLB.506151.30   small GTP-binding protein Rab11, putative
Trypanosoma cruzi TcCLB.511407.60   small GTP-binding protein Rab11, putative
Toxoplasma gondii TGME49_289680   Ras-related protein Rab11
Theileria parva TP01_1204   GTP-binding protein rab11, putative
Trichomonas vaginalis TVAG_134510   RAB-18, putative
Trichomonas vaginalis TVAG_169740   RAB 19, 41 and, putative

Essentiality

Tb927.8.4330 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.4330 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.4330 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.4330 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.4330 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F53G12.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F53G12.1 Caenorhabditis elegans larval arrest wormbase
CELE_F53G12.1 Caenorhabditis elegans larval lethal wormbase
CELE_F53G12.1 Caenorhabditis elegans slow growth wormbase
CELE_F53G12.1 Caenorhabditis elegans sterile wormbase
TGME49_289680 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.8.4330 (Trypanosoma brucei), small GTP-binding protein Rab11
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