pI: 4.8856 |
Length (AA): 145 |
MW (Da): 15902 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 124 | 2zdi (C) | 5 | 147 | 22.00 | 0 | 0.95 | 0.947479 | -0.5 |
3 | 144 | 4uos (A) | 3 | 156 | 11.00 | 0.025 | 0.03 | 1.10531 | -1.33 |
9 | 103 | 5nnv (A) | 311 | 849 | 28.00 | 0.17 | 0.16 | 0.836972 | 0.49 |
15 | 103 | 1fxk (A) | 13 | 108 | 27.00 | 0.43 | 1 | 0.930593 | -0.22 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128303)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G22480 | putative prefoldin subunit 2 |
Babesia bovis | BBOV_II001170 | KE2 family protein, putative |
Brugia malayi | Bm1_14985 | KE2 family protein |
Candida albicans | CaO19.2305 | similar to S. cerevisiae GIM4 (YEL003W) prefoldin subunit 2, component of Gim protein complex involved in tubulin folding |
Candida albicans | CaO19.9841 | similar to S. cerevisiae GIM4 (YEL003W) prefoldin subunit 2, component of Gim protein complex involved in tubulin folding |
Caenorhabditis elegans | CELE_H20J04.5 | Protein PFD-2 |
Cryptosporidium hominis | Chro.70511 | hypothetical protein |
Cryptosporidium parvum | cgd7_4630 | hypothetical protein |
Dictyostelium discoideum | DDB_G0267594 | prefoldin beta-like domain containing protein |
Drosophila melanogaster | Dmel_CG6302 | lethal (3) 01239 |
Echinococcus granulosus | EgrG_000722800 | prefoldin subunit 2 |
Entamoeba histolytica | EHI_113900 | prefoldin subunit 2, putative |
Echinococcus multilocularis | EmuJ_000722800 | prefoldin subunit 2 |
Giardia lamblia | GL50803_11713 | Prefoldin subunit 2 |
Homo sapiens | ENSG00000143256 | prefoldin subunit 2 |
Leishmania braziliensis | LbrM.09.0750 | prefoldin subunit 2, putative |
Leishmania donovani | LdBPK_090720.1 | prefoldin subunit 2, putative |
Leishmania infantum | LinJ.09.0720 | prefoldin subunit 2, putative |
Leishmania major | LmjF.09.0670 | prefoldin subunit 2, putative |
Leishmania mexicana | LmxM.09.0670 | prefoldin subunit 2, putative |
Loa Loa (eye worm) | LOAG_03812 | KE2 family protein |
Mus musculus | 18637 | prefoldin 2 |
Neospora caninum | NCLIV_000520 | hypothetical protein, conserved |
Oryza sativa | 4352232 | Os12g0485800 |
Oryza sativa | 4350745 | Os11g0568500 |
Plasmodium berghei | PBANKA_1025800 | prefoldin subunit 2, putative |
Plasmodium falciparum | PF3D7_1416900 | prefoldin subunit 2, putative |
Plasmodium knowlesi | PKNH_1341200 | prefoldin subunit 2, putative |
Plasmodium vivax | PVX_085605 | prefoldin subunit 2, putative |
Plasmodium yoelii | PY05659 | probable prefoldin subunit 2 |
Saccharomyces cerevisiae | YEL003W | Gim4p |
Schistosoma japonicum | Sjp_0012120 | ko:K09549 prefoldin subunit 2, putative |
Schistosoma mansoni | Smp_030290 | prefoldin subunit 2 |
Schmidtea mediterranea | mk4.003861.00 | |
Schmidtea mediterranea | mk4.005213.01 | |
Trypanosoma brucei gambiense | Tbg972.11.14140 | prefoldin subunit 2, putative |
Trypanosoma brucei | Tb927.11.12680 | prefoldin subunit 2, putative |
Trypanosoma cruzi | TcCLB.511483.40 | prefoldin subunit 2, putative |
Trypanosoma cruzi | TcCLB.508777.180 | prefoldin subunit 2, putative |
Toxoplasma gondii | TGME49_293580 | prefoldin subunit protein |
Theileria parva | TP04_0469 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_084710 | prefoldin subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.4520 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.4520 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.4520 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.4520 this record | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_H20J04.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_H20J04.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_H20J04.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_H20J04.5 | Caenorhabditis elegans | sterile | wormbase |
TGME49_293580 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Type | Source | Notes |
---|---|---|
soluble recombinant protein | Structural Genomics for Pathogenic Protozoa (SGPP) | Tbru021645; Recombinant protein: full-length; Source: T brucei; prefoldin subunit 2, putative ; |
1 literature reference was collected for this gene.