Detailed view for Tb927.8.6940

Basic information

TDR Targets ID: 12766
Trypanosoma brucei, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.4542 | Length (AA): 1460 | MW (Da): 164959 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_129754)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG17687   CG17687 gene product from transcript CG17687-RA
Echinococcus granulosus EgrG_001179000   WD repeat containing protein 96
Echinococcus multilocularis EmuJ_001179000   WD repeat containing protein 96
Homo sapiens ENSG00000197748   cilia and flagella associated protein 43
Leishmania braziliensis LbrM.31.3600   hypothetical protein, conserved
Leishmania donovani LdBPK_313290.1   hypothetical protein, conserved
Leishmania infantum LinJ.31.3290   hypothetical protein, conserved
Leishmania major LmjF.31.3150   hypothetical protein, conserved
Leishmania mexicana LmxM.30.3150   hypothetical protein, conserved
Mus musculus ENSMUSG00000044948   cilia and flagella associated protein 43
Neospora caninum NCLIV_068070   hypothetical protein, conserved
Schistosoma japonicum Sjp_0089410   IPR001680,WD-40 repeat;IPR011046,WD40-like,domain-containing
Schistosoma mansoni Smp_126970   hypothetical protein
Schmidtea mediterranea mk4.001703.02   Chromosome 10 open reading frame 79
Trypanosoma brucei gambiense Tbg972.4.5540   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.8.7150   hypothetical protein, conserved
Trypanosoma brucei Tb927.4.5380   hypothetical protein, conserved
Trypanosoma brucei Tb927.8.6940   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_12060   hypothetical protein
Trypanosoma congolense TcIL3000_8_6910   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_34830   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509913.30   hypothetical protein, conserved
Toxoplasma gondii TGME49_277930   hypothetical protein
Trichomonas vaginalis TVAG_119740   conserved hypothetical protein
Trichomonas vaginalis TVAG_075830   conserved hypothetical protein

Essentiality

Tb927.8.6940 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.6940 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.6940 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.6940 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.6940 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.4.5380 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.4.5380 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.5380 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.4.5380 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_277930 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tb927.8.6940 (Trypanosoma brucei), hypothetical protein, conserved
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