pI: 5.5658 |
Length (AA): 800 |
MW (Da): 89755 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
90 | 679 | 5hb3 (A) | 450 | 1011 | 14.00 | 0 | 0.88 | 0.6488 | 1.35 |
128 | 724 | 4n5c (E) | 231 | 811 | 16.00 | 0 | 1 | 0.59755 | 1.37 |
451 | 611 | 2fo7 (A) | 1 | 129 | 36.00 | 0.000000000025 | 0.93 | 0.32375 | 0.61 |
484 | 543 | 2vsy (A) | 22 | 81 | 17.00 | 0 | 0.26 | 0.2623 | -0.23 |
582 | 693 | 2vyi (A) | 88 | 199 | 21.00 | 0 | 1 | 0.5513 | -1.33 |
649 | 786 | 1hh8 (A) | 33 | 170 | 9.00 | 0.41 | 0.07 | 0.3236 | -0.63 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Bloodstream Form. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_129672)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_11660 | TPR Domain containing protein |
Brugia malayi | Bm1_14980 | TPR Domain containing protein |
Caenorhabditis elegans | CELE_Y41G9A.1 | Protein OSM-5 |
Drosophila melanogaster | Dmel_CG12548 | no mechanoreceptor potential B |
Echinococcus granulosus | EgrG_000880600 | intraflagellar transport protein 88 |
Echinococcus multilocularis | EmuJ_000880600 | intraflagellar transport protein 88 |
Giardia lamblia | GL50803_16660 | Intraflagellar transport particle protein IFT88 |
Homo sapiens | ENSG00000032742 | intraflagellar transport 88 |
Leishmania braziliensis | LbrM.27.1230 | intraflagellar transport protein IFT88, putative |
Leishmania donovani | LdBPK_271010.1 | intraflagellar transport protein 88, putative |
Leishmania infantum | LinJ.27.1010 | intraflagellar transport protein IFT88, putative |
Leishmania major | LmjF.27.1130 | intraflagellar transport protein IFT88, putative |
Leishmania mexicana | LmxM.27.1130 | intraflagellar transport protein IFT88, putative |
Loa Loa (eye worm) | LOAG_03811 | TPR Domain containing protein |
Loa Loa (eye worm) | LOAG_14411 | TPR Domain containing protein |
Loa Loa (eye worm) | LOAG_14975 | hypothetical protein |
Mus musculus | ENSMUSG00000040040 | intraflagellar transport 88 |
Neospora caninum | NCLIV_002500 | intraflagellar transport particle protein, putative |
Schistosoma japonicum | Sjp_0060900 | Intraflagellar transport protein 88 homolog, putative |
Schistosoma mansoni | Smp_135480 | tetratricopeptide repeat protein 10 tpr10 |
Schmidtea mediterranea | mk4.003178.00 | |
Trypanosoma brucei gambiense | Tbg972.11.1880 | intraflagellar transport protein IFT88, putative |
Trypanosoma brucei | Tb927.11.1740 | intraflagellar transport protein 88 |
Toxoplasma gondii | TGME49_207410 | tetratricopeptide repeat-containing protein |
Toxoplasma gondii | TGME49_207407 | hypothetical protein |
Trichomonas vaginalis | TVAG_324940 | tetratricopeptide repeat protein, tpr, putative |
Trichomonas vaginalis | TVAG_392700 | tetratricopeptide repeat protein 10, tpr10, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.55.0006 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.55.0006 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.55.0006 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.55.0006 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_207410 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_207407 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.