pI: 5.2035 |
Length (AA): 651 |
MW (Da): 76814 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
99 | 321 | 4tql (A) | 15 | 230 | 24.00 | 0.0002 | 0.97 | 0.70675 | -0.98 |
179 | 350 | 4uos (A) | 3 | 178 | 20.00 | 0.98 | 0.73 | 0.680409 | -1.94 |
185 | 383 | 3l4q (C) | 433 | 588 | 34.00 | 0.58 | 0.57 | 0.357884 | 0.64 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_130359)
Species | Accession | Gene Product |
---|---|---|
Drosophila melanogaster | Dmel_CG10958 | CG10958 gene product from transcript CG10958-RA |
Echinococcus granulosus | EgrG_000085100 | coiled coil domain containing protein 164 |
Echinococcus granulosus | EgrG_001118000 | FAR 17a AIG1 protein |
Echinococcus multilocularis | EmuJ_000085100 | coiled coil domain containing protein 164 |
Echinococcus multilocularis | EmuJ_001118000 | FAR 17a AIG1 protein |
Giardia lamblia | GL50803_16237 | Hypothetical protein |
Homo sapiens | ENSG00000157856 | dynein regulatory complex subunit 1 |
Leishmania braziliensis | LbrM.35.6950 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_366900.1 | Sperm tail/Sperm tail C-terminal domain containing protein, putative |
Leishmania infantum | LinJ.36.6900 | hypothetical protein, conserved |
Leishmania major | LmjF.36.6590 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.36.6590 | hypothetical protein, conserved |
Mus musculus | ENSMUSG00000073102 | dynein regulatory complex subunit 1 |
Neospora caninum | NCLIV_038490 | hypothetical protein, conserved |
Plasmodium berghei | PBANKA_1038600 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_1403400 | conserved Plasmodium protein, unknown function |
Plasmodium knowlesi | PKNH_1354700 | conserved Plasmodium protein, unknown function |
Plasmodium vivax | PVX_086265 | hypothetical protein, conserved |
Plasmodium yoelii | PY05274 | hypothetical protein |
Schistosoma japonicum | Sjp_0034050 | similar to UPF0407 protein CG10958, putative |
Schistosoma mansoni | Smp_135670 | hypothetical protein |
Schmidtea mediterranea | mk4.019010.00 | |
Trypanosoma brucei gambiense | Tbg972.10.9650 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.7880 | Sperm tail/Sperm tail C-terminal domain containing protein, putative |
Trypanosoma congolense | TcIL3000_10_6750 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.503779.10 | Sperm tail/Sperm tail C-terminal domain containing protein, putative |
Trypanosoma cruzi | TcCLB.504025.19 | Sperm tail/Sperm tail C-terminal domain containing protein, putative |
Trypanosoma cruzi | TcCLB.506247.380 | Sperm tail/Sperm tail C-terminal domain containing protein, putative |
Toxoplasma gondii | TGME49_267875 | NBP2b protein, putative |
Trichomonas vaginalis | TVAG_283010 | cingulin, putative |
Trichomonas vaginalis | TVAG_117030 | myosin heavy chain, cardiac muscle isoform, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.7880 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.7880 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.7880 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.7880 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_267875 | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1
1 literature reference was collected for this gene.