pI: 5.8466 |
Length (AA): 1127 |
MW (Da): 125404 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128382)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G48760 | AP-3 complex subunit delta |
Brugia malayi | Bm1_55840 | Adaptin |
Brugia malayi | Bm1_57425 | Adaptin |
Candida albicans | CaO19.248 | similar to S. cerevisiae APL5 (YPL195W) delta-like, large subunit of the clathrin-associated protein AP-3 complex |
Candida albicans | CaO19.7879 | similar to S. cerevisiae APL5 (YPL195W) delta-like, large subunit of the clathrin-associated protein AP-3 complex |
Caenorhabditis elegans | CELE_W09G10.4 | Protein APD-3, isoform B |
Dictyostelium discoideum | DDB_G0279537 | adaptor-related protein complex 3, delta 1 subunit |
Drosophila melanogaster | Dmel_CG10986 | garnet |
Echinococcus granulosus | EgrG_000083800 | Clathrin coatomer adaptor adaptin N terminal |
Entamoeba histolytica | EHI_164810 | Adapter-related protein complex 3 (AP-3) subunit, putative |
Echinococcus multilocularis | EmuJ_000083800 | Clathrin coatomer adaptor, adaptin, N terminal |
Homo sapiens | ENSG00000065000 | adaptor-related protein complex 3, delta 1 subunit |
Leishmania braziliensis | LbrM.08.0090 | adaptor complex protein (AP) 3 delta subunit 1, putative |
Leishmania donovani | LdBPK_080090.1 | adaptor complex protein (AP) 3 delta subunit 1, putative |
Leishmania infantum | LinJ.08.0090 | adaptor complex protein (AP) 3 delta subunit 1, putative |
Leishmania major | LmjF.08.0090 | adaptor complex protein (AP) 3 delta subunit 1, putative |
Leishmania mexicana | LmxM.08.0090 | adaptor complex protein (AP) 3 delta subunit 1, putative |
Loa Loa (eye worm) | LOAG_02545 | hypothetical protein |
Mus musculus | ENSMUSG00000020198 | adaptor-related protein complex 3, delta 1 subunit |
Neospora caninum | NCLIV_053720 | adaptin, putative |
Oryza sativa | 4324036 | Os01g0512200 |
Saccharomyces cerevisiae | YPL195W | Apl5p |
Schistosoma japonicum | Sjp_0036880 | AP-3 complex subunit delta-1, putative |
Schistosoma mansoni | Smp_138860 | hypothetical protein |
Schmidtea mediterranea | mk4.000443.00 | |
Schmidtea mediterranea | mk4.000875.02 | |
Schmidtea mediterranea | mk4.000875.04 | AP-3 complex subunit delta-1 |
Schmidtea mediterranea | mk4.000875.03 | AP-3 complex subunit delta-1 |
Trypanosoma brucei gambiense | Tbg972.5.5040 | delta-adaptin, putative,adaptor complex protein (AP) 3 delta subunit 1, putative |
Trypanosoma brucei | Tb927.5.3610 | adaptor complex protein (AP) 3 delta subunit 1, putative |
Trypanosoma congolense | TcIL3000_5_4050 | delta-adaptin, putative |
Trypanosoma cruzi | TcCLB.511653.10 | delta-adaptin, putative |
Trypanosoma cruzi | TcCLB.507811.20 | delta-adaptin, putative |
Toxoplasma gondii | TGME49_309370 | adaptin n terminal region domain-containing protein |
Trichomonas vaginalis | TVAG_170460 | AP-3 complex subunit delta, putative |
Trichomonas vaginalis | TVAG_123380 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_159440 | AP-3 complex subunit delta, putative |
Trichomonas vaginalis | TVAG_457300 | AP-3 complex subunit delta-1, putative |
Trichomonas vaginalis | TVAG_375210 | yks4 protein, putative |
Trichomonas vaginalis | TVAG_415510 | AP-3 complex subunit delta-1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.3610 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.3610 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.3610 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.3610 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_W09G10.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_W09G10.4 | Caenorhabditis elegans | larval arrest | wormbase |
TGME49_309370 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.