pI: 8.4251 |
Length (AA): 241 |
MW (Da): 27099 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128043)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G21110 | G10 family protein |
Babesia bovis | BBOV_III003890 | G10 protein family protein |
Brugia malayi | Bm1_47455 | G10 protein homolog |
Candida albicans | CaO19.4855 | potential spliceosome complex factor |
Candida albicans | CaO19.12318 | potential spliceosome complex factor |
Caenorhabditis elegans | CELE_C07A9.2 | Protein C07A9.2 |
Cryptosporidium hominis | Chro.70126 | G10 protein |
Cryptosporidium parvum | cgd7_1020 | G10 protein |
Dictyostelium discoideum | DDB_G0270360 | hypothetical protein |
Drosophila melanogaster | Dmel_CG1639 | lethal (1) 10Bb |
Echinococcus granulosus | EgrG_000752600 | protein bud31 |
Echinococcus multilocularis | EmuJ_000752600 | protein bud31 |
Homo sapiens | ENSG00000106245 | BUD31 homolog (S. cerevisiae) |
Leishmania donovani | LdBPK_090410.1 | G10 protein, putative |
Leishmania infantum | LinJ.09.0410 | hypothetical protein, conserved |
Leishmania major | LmjF.09.0260 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.09.0260 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04393 | G10 protein |
Mus musculus | 102642043 | protein BUD31 homolog |
Mus musculus | ENSMUSG00000038722 | BUD31 homolog (yeast) |
Neospora caninum | NCLIV_063410 | G10 protein, putative |
Oryza sativa | 4324760 | Os01g0857700 |
Oryza sativa | 4337198 | Os04g0646100 |
Oryza sativa | 4338942 | Os05g0446300 |
Oryza sativa | 4351510 | Os12g0149800 |
Onchocerca volvulus | OVOC7683 |
|
Plasmodium berghei | PBANKA_1237500 | pre-mRNA-splicing factor BUD31, putative |
Plasmodium falciparum | PF3D7_0522800 | pre-mRNA-splicing factor BUD31, putative |
Plasmodium knowlesi | PKNH_1010100 | pre-mRNA-splicing factor BUD31, putative |
Plasmodium vivax | PVX_080110 | G10 protein, putative |
Plasmodium yoelii | PY00044 | g10 protein |
Saccharomyces cerevisiae | YCR063W | Bud31p |
Schistosoma japonicum | Sjp_0024330 | Protein BUD31 homolog, putative |
Schistosoma mansoni | Smp_092380 | g10 protein homolog |
Schmidtea mediterranea | mk4.003032.03 | Protein BUD31 homolog |
Schmidtea mediterranea | mk4.000852.03 | Protein BUD31 homolog |
Schmidtea mediterranea | mk4.013193.00 | Protein BUD31 homolog |
Trypanosoma brucei gambiense | Tbg972.10.8150 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.6650 | G10 protein homologue, putative |
Trypanosoma congolense | TcIL3000_0_39570 | G10 protein homologue, putative |
Trypanosoma cruzi | TcCLB.510187.260 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_246620 | G10 family protein |
Theileria parva | TP02_0217 | G10 protein, putative |
Trichomonas vaginalis | TVAG_103280 | g10 protein homologue, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.6650 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.6650 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.6650 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.6650 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C07A9.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C07A9.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C07A9.2 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1237500 | Plasmodium berghei | Essential | plasmo |
TGME49_246620 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.