Detailed view for PF3D7_1032100

Basic information

TDR Targets ID: 1388
Plasmodium falciparum, mRNA-decapping enzyme subunit 1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.5102 | Length (AA): 1190 | MW (Da): 137986 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06058   Dcp1-like decapping family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005575   cellular_component  
GO:0003674   molecular_function  
GO:0008150   biological_process  
GO:0008047   enzyme activator activity  
GO:0000290   deadenylation-dependent decapping of nuclear-transcribed mRNA  
GO:0043085   positive regulation of catalytic activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
298 424 1q67 (A) 22 228 20.00 0 1 0.16 -1.71
3 333 4wat (A) 153 513 15.00 0.078 0.01 0.362151 -0.04
5 206 2bvl (A) 40 248 29.00 0.12 0.11 0.281148 0.04
587 728 4r5c (A) 156 302 27.00 0.16 1 0.370728 -0.37
665 768 3ik2 (A) 392 506 37.00 0.79 0.14 0.326795 0.29
979 1186 4tql (A) 10 221 10.00 0.000013 0.01 0.30749 -0.73
1040 1190 4uos (A) 2 152 12.00 0.043 0 0.327591 -1.22
5 206 2bvl (A) 40 248 28.00 0.11 0.07 0.26052 0.12
21 264 4u0r (A) 184 465 27.00 0.92 0.21 0.322934 -0.01
289 420 4b6h (A) 2 128 29.00 0.0000017 1 0.518498 -0.72
660 969 4o87 (A) 3 278 30.00 0.057 0.94 0.340583 0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, merozoite, sporozoite, early ring, Oocyst, Ring, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_146821)

Species Accession Gene Product
Cryptosporidium hominis Chro.50464   hypothetical protein
Cryptosporidium parvum cgd5_3890   possible apicomplexan specific, low complexity protein
Plasmodium berghei PBANKA_0515900   mRNA-decapping enzyme subunit 1, putative
Plasmodium falciparum PF3D7_1032100   mRNA-decapping enzyme subunit 1, putative
Plasmodium knowlesi PKNH_0616900   mRNA-decapping enzyme subunit 1, putative
Plasmodium vivax PVX_111120   asparagine-rich antigen, putative
Plasmodium yoelii PY00841   hypothetical protein
Theileria parva TP04_0757   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1032100 (Plasmodium falciparum), mRNA-decapping enzyme subunit 1, putative
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