Detailed view for PF3D7_1035400

Basic information

TDR Targets ID: 1419
Plasmodium falciparum, merozoite surface protein 3
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.357 | Length (AA): 354 | MW (Da): 40120 | Paralog Number: 4

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07133   Merozoite surface protein (SPAM)

Gene Ontology

Mouse over links to read term descriptions.
GO:0030260   entry into host cell  
GO:0005575   cellular_component  
GO:0003674   molecular_function  

Metabolic Pathways

Malaria (KEGG)

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
77 110 1psm () 5 38 88.00 0.00000071 0.26 1.1 -1.15
50 175 1y4c (A) 354 653 17.00 0.35 0.51 0.628232 -1.26
77 110 1psm (A) 5 38 88.00 0.0000038 0.35 1.09535 -0.93
79 324 4tql (A) 10 238 26.00 0.00016 1 0.932215 -0.46
249 346 3u59 (A) 1 98 13.00 0.29 0 0.565136 -2.03
85 212 4uos (A) 32 150 32.00 0.4 1 0.649958 -1.03
89 126 1psm (A) 1 38 66.00 0.00011 0.5 0.876738 -0.76
95 351 4tql (A) 10 238 26.00 0.0061 1 0.904541 -0.49
247 338 3q8t (A) 174 265 21.00 0.2 0.01 0.66557 -2.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1PSM:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, early schizont, late schizont, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 16 hs, late trophozoite, Sporozoite, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Oocyst. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_173153)

Species Accession Gene Product
Plasmodium falciparum PF3D7_1035400   merozoite surface protein 3
Plasmodium falciparum PF3D7_1035500   merozoite surface protein 6
Plasmodium falciparum PF3D7_1035600   merozoite surface protein
Plasmodium falciparum PF3D7_1036000   merozoite surface protein
Plasmodium falciparum PF3D7_1036300   duffy binding-like merozoite surface protein 2

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1035400 (Plasmodium falciparum), merozoite surface protein 3
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