pI: 8.4667 |
Length (AA): 423 |
MW (Da): 46047 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 412 | 4ohx (A) | 4 | 422 | 26.00 | 0 | 1 | 1.23094 | -0.09 |
8 | 412 | 4ohx (A) | 7 | 422 | 28.00 | 0 | 1 | 1.20025 | 0.01 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127602)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G39930 | CLP1-like protein 5 |
Arabidopsis thaliana | AT3G04680 | CLP-like protein 3 |
Babesia bovis | BBOV_IV008810 | pre-mRNA cleavage complex II protein Clp1, putative |
Brugia malayi | Bm1_20975 | Pre-mRNA cleavage complex II protein Clp1 |
Candida albicans | CaO19.6931 | cleavage and polyadenylation factor CF I component |
Candida albicans | CaO19.14193 | cleavage and polyadenylation factor CF I component |
Caenorhabditis elegans | CELE_F59A2.4 | Protein CLPF-1, isoform B |
Cryptosporidium hominis | Chro.50085 | pre-mRNA cleavage complex ii protein clp1-related |
Cryptosporidium parvum | cgd5_2880 | C1p1p GTpase. Pre-mRNA cleavaage complex protein |
Dictyostelium discoideum | DDB_G0285507 | pre-mRNA cleavage complex subunit |
Drosophila melanogaster | Dmel_CG5970 | crowded by cid |
Echinococcus granulosus | EgrG_000118700 | polyribonucleotide 5' hydroxyl kinase Clp1 |
Entamoeba histolytica | EHI_008100 | ATP/GTP-binding protein, putative |
Echinococcus multilocularis | EmuJ_000118700 | polyribonucleotide 5' hydroxyl kinase Clp1 |
Homo sapiens | ENSG00000172409 | cleavage and polyadenylation factor I subunit 1 |
Leishmania braziliensis | LbrM.30.2360 | pre-mRNA cleavage complex II Clp1-like protein |
Leishmania donovani | LdBPK_302420.1 | pre-mRNA cleavage complex II Clp1-like protein |
Leishmania infantum | LinJ.30.2420 | pre-mRNA cleavage complex II Clp1-like protein |
Leishmania major | LmjF.30.2410 | pre-mRNA cleavage complex II Clp1-like protein |
Leishmania mexicana | LmxM.29.2410 | pre-mRNA cleavage complex II Clp1-like protein |
Loa Loa (eye worm) | LOAG_11732 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06833 | hypothetical protein |
Mus musculus | ENSMUSG00000027079 | CLP1, cleavage and polyadenylation factor I subunit |
Neospora caninum | NCLIV_001590 | hypothetical protein |
Oryza sativa | 4328733 | Os02g0217500 |
Plasmodium berghei | PBANKA_0709200 | polyribonucleotide 5'-hydroxyl-kinase Clp1, putative |
Plasmodium falciparum | PF3D7_0821600 | polyribonucleotide 5'-hydroxyl-kinase Clp1, putative |
Plasmodium knowlesi | PKNH_1315600 | polyribonucleotide 5'-hydroxyl-kinase Clp1, putative |
Plasmodium vivax | PVX_089285 | hypothetical protein, conserved |
Plasmodium yoelii | PY04248 | pre-mRNA cleavage complex ii protein clp1-related |
Saccharomyces cerevisiae | YOR250C | Clp1p |
Schistosoma japonicum | Sjp_0062400 | Pre-mRNA cleavage complex II protein Clp1, putative |
Schistosoma mansoni | Smp_019130 | cleavage/polyadenylation factor ia subunit clp1p |
Schmidtea mediterranea | mk4.017186.00 | Protein CLP1 homolog |
Schmidtea mediterranea | mk4.001470.04 | |
Schmidtea mediterranea | mk4.004365.02 | Protein CLP1 homolog |
Trypanosoma brucei gambiense | Tbg972.6.3460 | pre-mRNA cleavage complex II Clp1-like, conserved, putative |
Trypanosoma brucei | Tb927.6.3690 | pre-mRNA cleavage complex II Clp1-like, conserved |
Trypanosoma congolense | TcIL3000_6_3250 | pre-mRNA cleavage complex II Clp1-like, conserved, putative |
Trypanosoma congolense | TcIL3000_0_32350 | pre-mRNA cleavage complex II Clp1-like, conserved |
Trypanosoma cruzi | TcCLB.507027.59 | pre-mRNA cleavage complex II Clp1 protein, putative |
Trypanosoma cruzi | TcCLB.506941.229 | pre-mRNA cleavage complex II Clp1 protein, putative |
Theileria parva | TP01_0895 | hypothetical protein |
Trichomonas vaginalis | TVAG_162880 | pre-mRNA cleavage complex II protein Clp1, putative |
Trichomonas vaginalis | TVAG_317830 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.3690 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.3690 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.3690 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.3690 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F59A2.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F59A2.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F59A2.4 | Caenorhabditis elegans | sterile | wormbase |
YOR250C | Saccharomyces cerevisiae | inviable | yeastgenome |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.