Detailed view for Tb927.10.740

Basic information

TDR Targets ID: 14601
Trypanosoma brucei, structural maintenance of chromosome 4, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.4404 | Length (AA): 1366 | MW (Da): 154703 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02463   RecF/RecN/SMC N terminal domain
PF06470   SMC proteins Flexible Hinge Domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005694   chromosome  
GO:0005515   protein binding  
GO:0005524   ATP binding  
GO:0051276   chromosome organization and biogenesis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_127440)

Species Accession Gene Product
Arabidopsis thaliana AT5G48600   structural maintenance of chromosomes protein 4
Babesia bovis BBOV_III010300   SMC family, C-terminal domain containing protein
Brugia malayi Bm1_07830   SMC family, C-terminal domain containing protein
Candida albicans CaO19.8579   potential SMC chromosomal ATPase similar to S. cerevisiae SMC4 (YLR086W) nuclear condensin complex ATPase
Candida albicans CaO19.964   potential SMC chromosomal ATPase similar to S. cerevisiae SMC4 (YLR086W) nuclear condensin complex ATPase
Caenorhabditis elegans CELE_F35G12.8   Protein SMC-4
Caenorhabditis elegans CELE_R13G10.1   Protein DPY-27
Cryptosporidium hominis Chro.70215   stable maintenance of chromosomes; Smc4p
Cryptosporidium parvum cgd7_1850   SMC4SMC4, chromosomal ATpase with giant coiled coil regions
Dictyostelium discoideum DDB_G0286403   structural maintenance of chromosome protein
Drosophila melanogaster Dmel_CG11397   gluon
Echinococcus granulosus EgrG_000517500   structural maintenance of chromosomes protein
Entamoeba histolytica EHI_199700   SMC4 protein, putative
Echinococcus multilocularis EmuJ_000517500   structural maintenance of chromosomes protein
Giardia lamblia GL50803_17465   SMC4-like protein
Homo sapiens ENSG00000113810   structural maintenance of chromosomes 4
Leishmania braziliensis LbrM.21.1570   hypothetical protein, conserved
Leishmania donovani LdBPK_211580.1   RecF/RecN/SMC N terminal domain/SMC proteins Flexible Hinge Domain, putative
Leishmania infantum LinJ.21.1580   hypothetical protein, conserved
Leishmania major LmjF.21.1330   hypothetical protein, conserved
Leishmania mexicana LmxM.21.1330partial   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_02100   hypothetical protein
Loa Loa (eye worm) LOAG_10473   hypothetical protein
Loa Loa (eye worm) LOAG_10474   Smc4l1 protein
Mycobacterium leprae ML1629c   PROBABLE CHROMOSOME PARTITION PROTEIN SMC
Mus musculus ENSMUSG00000034349   structural maintenance of chromosomes 4
Neospora caninum NCLIV_031540   chromosome condensation protein, putative
Oryza sativa 9267154   Os05g0497100
Onchocerca volvulus OVOC2348  
Plasmodium berghei PBANKA_1108700   structural maintenance of chromosomes protein 4, putative
Plasmodium falciparum PF3D7_0509100   structural maintenance of chromosomes protein 4, putative
Plasmodium knowlesi PKNH_1024500   structural maintenance of chromosomes protein 4, putative
Plasmodium vivax PVX_098020   chromosome condensation protein, putative
Plasmodium yoelii PY03258   chromosome assembly protein xcap-c
Saccharomyces cerevisiae YLR086W   condensin subunit SMC4
Schistosoma japonicum Sjp_0302410   ko:K06675 structural maintenance of chromosome 4, putative
Schistosoma japonicum Sjp_0084840   ko:K06675 structural maintenance of chromosome 4, putative
Schistosoma mansoni Smp_173700   chondroitin sulfate proteoglycan
Schmidtea mediterranea mk4.000285.04   Structural maintenance of chromosomes protein 4
Schmidtea mediterranea mk4.000285.05  
Trypanosoma brucei gambiense Tbg972.10.760   structural maintenance of chromosome 4, putative
Trypanosoma brucei Tb927.10.740   structural maintenance of chromosome 4, putative
Trypanosoma brucei Tb11.v5.0750   dual specificity protein phosphatase, putative
Trypanosoma brucei Tb11.v5.0749   structural maintenance of chromosome 4, putative
Trypanosoma congolense TcIL3000_10_600   structural maintenance of chromosome 4, putative
Trypanosoma cruzi TcCLB.506855.90   structural maintenance of chromosome protein 4, putative
Trypanosoma cruzi TcCLB.508779.90   structural maintenance of chromosome protein 4, putative
Toxoplasma gondii TGME49_231170   RecF/RecN/SMC N terminal domain-containing protein
Treponema pallidum TP0367   chromosome segregation protein
Theileria parva TP02_0117   hypothetical protein
Trichomonas vaginalis TVAG_160280   condensin subunit Smc4
Trichomonas vaginalis TVAG_434480   condensin subunit Smc4

Essentiality

Tb927.10.740 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.740 this record Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.740 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.740 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.740 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R13G10.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_R13G10.1 Caenorhabditis elegans larval arrest wormbase
CELE_R13G10.1 Caenorhabditis elegans slow growth wormbase
CELE_F35G12.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_F35G12.8 Caenorhabditis elegans larval arrest wormbase
YLR086W Saccharomyces cerevisiae inviable yeastgenome
TGME49_231170 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) increased (PATO:0000470) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.10.740 (Trypanosoma brucei), structural maintenance of chromosome 4, putative
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