pI: 10.3421 |
Length (AA): 428 |
MW (Da): 47214 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128388)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G04600 | RNA recognition motif-containing protein |
Babesia bovis | BBOV_IV003970 | RNA recognition motif containing protein |
Brugia malayi | Bm1_45185 | putative RNA binding protein |
Candida albicans | CaO19.7050 | RRM-containing orf similar to SPCC1827.05c and to NOP15 |
Candida albicans | CaO19_7050 | hypothetical protein |
Caenorhabditis elegans | CELE_T04A8.6 | Protein T04A8.6 |
Cryptosporidium hominis | Chro.70191 | mki67 (FHA domain) interacting nucleolar phosphoprotein (human) - like |
Cryptosporidium parvum | cgd7_1620 | nop15p/nopp34; nucleolar protein with 1 RRM domain |
Dictyostelium discoideum | DDB_G0275885 | hypothetical protein |
Drosophila melanogaster | Dmel_CG6937 | CG6937 gene product from transcript CG6937-RA |
Entamoeba histolytica | EHI_068680 | nucleolar phosphoprotein Nopp34, putative |
Echinococcus multilocularis | EmuJ_000452900 | expressed protein |
Giardia lamblia | GL50803_6054 | RNA binding protein, putative |
Homo sapiens | ENSG00000155438 | nucleolar protein interacting with the FHA domain of MKI67 |
Leishmania braziliensis | LbrM.10.1130 | RNA-binding protein-like protein |
Leishmania donovani | LdBPK_101110.1 | RNA-binding protein-like protein |
Leishmania infantum | LinJ.10.1110 | RNA-binding protein-like protein |
Leishmania major | LmjF.10.1030 | RNA-binding protein-like protein |
Leishmania mexicana | LmxM.10.1030 | RNA-binding protein-like protein |
Loa Loa (eye worm) | LOAG_00920 | hypothetical protein |
Mus musculus | ENSMUSG00000026377 | nucleolar protein interacting with the FHA domain of MKI67 |
Neospora caninum | NCLIV_052320 | RNA binding protein, putative |
Oryza sativa | 4345558 | Os08g0412200 |
Saccharomyces cerevisiae | YNL110C | Nop15p |
Schistosoma mansoni | Smp_078520 | nucleolar phosphoprotein |
Trypanosoma brucei gambiense | Tbg972.8.4210 | RNA-binding protein, putative |
Trypanosoma brucei | Tb927.8.4450 | RNA-binding protein, putative |
Trypanosoma congolense | TcIL3000_8_4220 | RNA-binding protein, putative |
Trypanosoma cruzi | TcCLB.509569.120 | RNA-binding protein, putative |
Trypanosoma cruzi | TcCLB.508989.30 | RNA-binding protein, putative |
Toxoplasma gondii | TGME49_215400 | RNA recognition motif-containing protein |
Theileria parva | TP01_1032 | RNA-binding protein, putative |
Trichomonas vaginalis | TVAG_139660 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_286120 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.4450 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.4450 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.4450 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.4450 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T04A8.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T04A8.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T04A8.6 | Caenorhabditis elegans | sterile | wormbase |
YNL110C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_215400 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.