pI: 8.604 |
Length (AA): 327 |
MW (Da): 37294 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
86 | 260 | 5m4y (C) | 40 | 220 | 16.00 | 0 | 0.24 | 0.702068 | -0.83 |
239 | 295 | 1gl2 (B) | 170 | 226 | 32.00 | 0.000024 | 0.01 | 0.552012 | -0.62 |
244 | 280 | 5buz (C) | 189 | 225 | 38.00 | 0 | 0.01 | 0.39705 | 0.57 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127926)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G24350 | syntaxin-32 |
Babesia bovis | BBOV_III006380 | conserved hypothetical protein |
Brugia malayi | Bm1_28080 | Syntaxin F55A11.2 |
Candida albicans | CaO19.13460 | similar to syntaxin required in ER to Golgi transport |
Candida albicans | CaO19.6039 | similar to syntaxin required in ER to Golgi transport |
Caenorhabditis elegans | CELE_F55A11.2 | Protein SYX-5 |
Cryptosporidium hominis | Chro.10317 | syntaxin 5 |
Cryptosporidium parvum | cgd1_2830 | syntaxin 5A ortholog, possible transmembrane domain or GPI at C-terminus |
Dictyostelium discoideum | DDB_G0277565 | t-SNARE family protein |
Drosophila melanogaster | Dmel_CG4214 | Syntaxin 5 |
Echinococcus granulosus | EgrG_000057500 | syntaxin 5 |
Echinococcus granulosus | EgrG_000086800 | syntaxin 5 |
Entamoeba histolytica | EHI_181290 | syntaxin, putative |
Entamoeba histolytica | EHI_080870 | syntaxin, putative |
Echinococcus multilocularis | EmuJ_000057500 | syntaxin 5 |
Echinococcus multilocularis | EmuJ_000086800 | syntaxin 5 |
Homo sapiens | ENSG00000162236 | syntaxin 5 |
Leishmania braziliensis | LbrM.32.0120 | Qa-SNARE protein |
Leishmania donovani | LdBPK_320070.1 | Qa-SNARE protein |
Leishmania infantum | LinJ.32.0070 | Qa-SNARE protein |
Leishmania major | LmjF.32.0070 | Qa-SNARE protein |
Leishmania mexicana | LmxM.31.0070 | syntaxin 5, putative |
Loa Loa (eye worm) | LOAG_09126 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10241 | hypothetical protein |
Mus musculus | ENSMUSG00000010110 | syntaxin 5A |
Neospora caninum | NCLIV_046380 | syntaxin, putative |
Plasmodium berghei | PBANKA_1346800 | Qa-SNARE protein, putative |
Plasmodium falciparum | PF3D7_1332000 | syntaxin, Qa-SNARE family |
Plasmodium knowlesi | PKNH_1268600 | syntaxin 5, putative |
Plasmodium vivax | PVX_082530 | syntaxin 5, putative |
Plasmodium yoelii | PY07410 | syntaxin 5 |
Plasmodium yoelii | PY07007 | syntaxin 5 |
Saccharomyces cerevisiae | YLR026C | Sed5p |
Schistosoma japonicum | Sjp_0043560 | ko:K08490 syntaxin 5, putative |
Schistosoma mansoni | Smp_176270 | syntaxin |
Schmidtea mediterranea | mk4.033554.00 | Putative syntaxin-5 |
Schmidtea mediterranea | mk4.001564.04 | Putative syntaxin-5 |
Schmidtea mediterranea | mk4.000182.06 | Putative syntaxin |
Trypanosoma brucei gambiense | Tbg972.10.16590 | syntaxin 5, putative |
Trypanosoma brucei | Tb927.10.14200 | syntaxin 5 |
Trypanosoma cruzi | TcCLB.511283.40 | syntaxin 5, putative |
Trypanosoma cruzi | TcCLB.506525.40 | syntaxin 5, putative |
Toxoplasma gondii | TGME49_226600 | syntaxin 5, putative |
Theileria parva | TP02_0324 | syntaxin 5, putative |
Trichomonas vaginalis | TVAG_318380 | syntaxin, putative |
Trichomonas vaginalis | TVAG_182300 | syntaxin-5, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14200 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14200 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14200 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.14200 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F55A11.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F55A11.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F55A11.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F55A11.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F55A11.2 | Caenorhabditis elegans | sterile | wormbase |
YLR026C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1346800 | Plasmodium berghei | Essential | plasmo |
TGME49_226600 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.