Detailed view for PF3D7_1103100

Basic information

TDR Targets ID: 1522
Plasmodium falciparum, 60S acidic ribosomal protein P1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.2641 | Length (AA): 118 | MW (Da): 13014 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00428   60s Acidic ribosomal protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0015934   large ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006414   translational elongation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 117 4beh (A) 6 113 50.00 0 0.96 1.21431 1.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_126872)

Species Accession Gene Product
Arabidopsis thaliana AT1G01100   60S acidic ribosomal protein P1-1
Arabidopsis thaliana AT5G24510   60S acidic ribosomal family protein
Arabidopsis thaliana AT4G00810   60S acidic ribosomal protein P1-2
Arabidopsis thaliana AT5G47700   60S acidic ribosomal protein P1-3
Babesia bovis BBOV_III008120   60S acidic ribosomal protein p1, putative
Brugia malayi Bm1_04915   60S acidic ribosomal protein P1
Candida albicans CaO19.10509   cytosolic ribosomal large subunit acidic protein P1A similar to S. cerevisiae RPP1A (YDL081C)
Candida albicans CaO19_7188   hypothetical protein
Candida albicans CaO19.7188   cytosolic ribosomal large subunit acidic protein P1B similar to S. cerevisiae cytosolic large subunit acidic stalk RPP1B (YDL130
Candida albicans CaO19.2992   cytosolic ribosomal large subunit acidic protein P1A similar to S. cerevisiae RPP1A (YDL081C)
Caenorhabditis elegans CELE_Y37E3.7   Protein RLA-1
Cryptosporidium hominis Chro.50141   acidic ribosomal protein P1
Cryptosporidium parvum cgd5_2370   60S acidic ribosomal protein LP1 like protein of possible plant origin
Dictyostelium discoideum DDB_G0277907   60S acidic ribosomal protein P1
Dictyostelium discoideum DDB_G0287995   60S acidic ribosomal protein P1 beta
Drosophila melanogaster Dmel_CG4087   Ribosomal protein LP1
Echinococcus granulosus EgrG_001195100   ribosomal protein lp1
Entamoeba histolytica EHI_104660   60S acidic ribosomal protein P1, putative
Entamoeba histolytica EHI_042930   60S acidic ribosomal protein P1, putative
Entamoeba histolytica EHI_042920   60S acidic riboomal protein P1, putative
Echinococcus multilocularis EmuJ_001195100   ribosomal protein lp1
Giardia lamblia GL50803_17337   Ribosomal protein P1B
Homo sapiens ENSG00000137818   ribosomal protein, large, P1
Leishmania braziliensis LbrM.03.0390   60S acidic ribosomal protein P2, putative
Leishmania braziliensis LbrM.03.0400   60S acidic ribosomal protein P2, putative
Leishmania donovani LdBPK_150430.1   60S acidic ribosomal protein, putative
Leishmania donovani LdBPK_030420.1   60S acidic ribosomal protein P2, putative
Leishmania infantum LinJ.03.0420   60S acidic ribosomal protein P2, putative
Leishmania infantum LinJ.15.0430   60S acidic ribosomal protein, putative
Leishmania infantum LinJ.15.0420   60S acidic ribosomal protein, putative
Leishmania major LmjF.15.0380   60S acidic ribosomal protein, putative
Leishmania major LmjF.15.0370   60S acidic ribosomal protein, putative
Leishmania major LmjF.03.0440   60S acidic ribosomal protein P2, putative
Leishmania major LmjF.03.0430   60S acidic ribosomal protein P2, putative
Leishmania mexicana LmxM.03.0440   60S acidic ribosomal protein P2, putative
Leishmania mexicana LmxM.15.0370   60S acidic ribosomal protein, putative
Loa Loa (eye worm) LOAG_09563   acidic ribosomal protein 1
Mus musculus ENSMUSG00000007892   ribosomal protein, large, P1
Neospora caninum NCLIV_026750   cyclin H, putative
Oryza sativa 4344516   Os08g0116500
Plasmodium berghei PBANKA_0943600   60S acidic ribosomal protein P1, putative
Plasmodium falciparum PF3D7_1103100   60S acidic ribosomal protein P1, putative
Plasmodium knowlesi PKNH_0900700   60S acidic ribosomal protein P1, putative
Plasmodium vivax PVX_090845   60S acidic ribosomal protein P1, putative
Plasmodium yoelii PY06972   acidic ribosomal protein P1 - hydromedusa
Saccharomyces cerevisiae YDL130W   ribosomal protein P1B
Saccharomyces cerevisiae YDL081C   ribosomal protein P1A
Schistosoma japonicum Sjp_0200190   ko:K02942 large subunit ribosomal protein LP1, putative
Schistosoma mansoni Smp_041980   60S ribosomal protein P1
Schmidtea mediterranea mk4.000346.12  
Schmidtea mediterranea mk4.000828.01   60S acidic ribosomal protein P1
Trypanosoma brucei gambiense Tbg972.10.4240   60S acidic ribosomal protein P2, putative
Trypanosoma brucei gambiense Tbg972.10.4250   60S acidic ribosomal protein P2, putative
Trypanosoma brucei Tb927.5.1820   60S acidic ribosomal protein, putative
Trypanosoma brucei Tb927.10.3380   60S acidic ribosomal protein P2, putative
Trypanosoma brucei Tb927.10.3370   60S acidic ribosomal protein P2, putative
Trypanosoma congolense TcIL3000_10_2820   60S acidic ribosomal protein P2, putative
Trypanosoma congolense TcIL3000_0_08620   60S acidic ribosomal protein, putative
Trypanosoma congolense TcIL3000_10_2810   60S acidic ribosomal protein P2, putative
Trypanosoma cruzi TcCLB.510267.20   60S acidic ribosomal protein P2, putative
Trypanosoma cruzi TcCLB.510823.70   60S acidic ribosomal protein, putative
Trypanosoma cruzi TcCLB.510309.40   60S acidic ribosomal protein P2, putative
Trypanosoma cruzi TcCLB.503505.10   60S acidic ribosomal protein P2, putative
Trypanosoma cruzi TcCLB.510309.50   60S acidic ribosomal protein P2, putative
Toxoplasma gondii TGME49_260260   ribosomal protein RPP1
Theileria parva TP04_0711   60S acidic ribosomal protein P1, putative
Trichomonas vaginalis TVAG_143780   60S acidic ribosomal protein P1, putative
Trichomonas vaginalis TVAG_348320   60S acidic ribosomal protein P2, putative
Trichomonas vaginalis TVAG_020470   60S acidic ribosomal protein P1, putative
Trichomonas vaginalis TVAG_392990   60S acidic ribosomal protein P1, putative
Trichomonas vaginalis TVAG_402510   60S acidic ribosomal protein P1, putative
Trichomonas vaginalis TVAG_067970   60S acidic ribosomal protein P1, putative

Essentiality

PF3D7_1103100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.1820 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.1820 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.1820 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.5.1820 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.3370 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.3370 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.3370 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.3370 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y37E3.7 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_0943600 Plasmodium berghei Essential plasmo
TGME49_260260 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1103100 (Plasmodium falciparum), 60S acidic ribosomal protein P1, putative
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