pI: 9.6815 |
Length (AA): 239 |
MW (Da): 26490 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Bloodstream Form. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126859)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_I001900 | conserved hypothetical protein |
Brugia malayi | Bm1_53075 | Synaptobrevin |
Caenorhabditis elegans | CELE_B0513.9 | Protein VAMP-8, isoform A |
Caenorhabditis elegans | CELE_T10H9.4 | Protein SNB-1 |
Caenorhabditis elegans | CELE_F23H12.1 | Protein SNB-2 |
Cryptosporidium parvum | cgd3_1070 | synaptobrevin like SNARE |
Cryptosporidium parvum | cgd3_1080 | hypothetical protein |
Dictyostelium discoideum | DDB_G0284951 | longin domain-containing protein |
Dictyostelium discoideum | DDB_G0280061 | synaptobrevin domain-containing protein |
Dictyostelium discoideum | DDB_G0290363 | synaptobrevin domain-containing protein |
Drosophila melanogaster | Dmel_CG17248 | neuronal Synaptobrevin |
Drosophila melanogaster | Dmel_CG12210 | Synaptobrevin |
Echinococcus granulosus | EgrG_000479200 | expressed protein |
Echinococcus granulosus | EgrG_000528000 | vesicle associated membrane protein |
Echinococcus granulosus | EgrG_000201000 | synaptobrevin |
Echinococcus granulosus | EgrG_000494400 | vesicle associated membrane protein |
Entamoeba histolytica | EHI_069370 | vesicle-associated membrane protein, putative |
Entamoeba histolytica | EHI_098490 | vesicle-associated membrane protein, putative |
Entamoeba histolytica | EHI_170630 | vesicle-associated membrane protein, putative |
Echinococcus multilocularis | EmuJ_000201000 | synaptobrevin |
Echinococcus multilocularis | EmuJ_000494400 | vesicle associated membrane protein |
Echinococcus multilocularis | EmuJ_000528000 | vesicle associated membrane protein |
Echinococcus multilocularis | EmuJ_000479200 | expressed protein |
Homo sapiens | ENSG00000049245 | vesicle-associated membrane protein 3 |
Homo sapiens | ENSG00000118640 | vesicle-associated membrane protein 8 |
Homo sapiens | ENSG00000139190 | vesicle-associated membrane protein 1 (synaptobrevin 1) |
Homo sapiens | ENSG00000220205 | vesicle-associated membrane protein 2 (synaptobrevin 2) |
Homo sapiens | ENSG00000117533 | vesicle-associated membrane protein 4 |
Leishmania braziliensis | LbrM.08.0030 | vesicle-associated membrane protein, putative |
Leishmania braziliensis | LbrM.21.1490 | vesicule-associated membrane protein, putative |
Leishmania donovani | LdBPK_080030.1 | vesicle-associated membrane protein, putative |
Leishmania donovani | LdBPK_211530.1 | vesicle-associated membrane protein, putative |
Leishmania infantum | LinJ.08.0030 | vesicle-associated membrane protein, putative |
Leishmania infantum | LinJ.21.1530 | vesicule-associated membrane protein, putative |
Leishmania major | LmjF.21.1290 | R-SNARE protein, putative |
Leishmania major | LmjF.08.0030 | Qc-SNARE protein, putative |
Leishmania mexicana | LmxM.08.0030 | Qc-SNARE protein, putative |
Leishmania mexicana | LmxM.21.1290 | vesicule-associated membrane protein, putative |
Loa Loa (eye worm) | LOAG_10872 | hypothetical protein |
Mus musculus | ENSMUSG00000026696 | vesicle-associated membrane protein 4 |
Mus musculus | ENSMUSG00000028955 | vesicle-associated membrane protein 3 |
Mus musculus | ENSMUSG00000050732 | vesicle-associated membrane protein 8 |
Mus musculus | ENSMUSG00000030337 | vesicle-associated membrane protein 1 |
Mus musculus | ENSMUSG00000020894 | vesicle-associated membrane protein 2 |
Neospora caninum | NCLIV_064090 | synaptobrevin domain-containing protein, putative |
Oryza sativa | 4331733 | Os03g0165800 |
Saccharomyces cerevisiae | YOR327C | SNAP receptor SNC2 |
Saccharomyces cerevisiae | YAL030W | SNAP receptor SNC1 |
Schistosoma japonicum | Sjp_0213170 | IPR001388,Synaptobrevin,domain-containing |
Schistosoma japonicum | Sjp_0023490 | ko:K08510 vesicle-associated membrane protein 1/2/3 (synaptobrevin I/II,, putative |
Schistosoma japonicum | Sjp_0215640 | Synaptobrevin-like protein, putative |
Schistosoma mansoni | Smp_055870 | hypothetical protein |
Schistosoma mansoni | Smp_123870 | vamp-2 |
Schistosoma mansoni | Smp_102160.1 | vamp-2 |
Schmidtea mediterranea | mk4.007083.00 | |
Schmidtea mediterranea | mk4.002446.02 | |
Schmidtea mediterranea | mk4.016055.00 | |
Schmidtea mediterranea | mk4.002579.03 | |
Schmidtea mediterranea | mk4.001200.03 | Synaptobrevin, putative |
Schmidtea mediterranea | mk4.019694.00 | |
Schmidtea mediterranea | mk4.000000.58 | |
Schmidtea mediterranea | mk4.007559.01 | |
Trypanosoma brucei gambiense | Tbg972.10.820 | vesicle-associated membrane protein, putative,synaptobrevin, putative |
Trypanosoma brucei gambiense | Tbg972.5.4970 | vesicle-associated membrane protein, putative,synaptobrevin, putative |
Trypanosoma brucei | Tb927.5.3560 | vesicle-associated membrane protein, putative |
Trypanosoma brucei | Tb927.10.790 | vesicle-associated membrane protein, putative |
Trypanosoma congolense | TcIL3000_10_640 | vesicle-associated membrane protein, putative |
Trypanosoma cruzi | TcCLB.511649.130 | vesicle-associated membrane protein, putative |
Trypanosoma cruzi | TcCLB.507811.60 | vesicle-associated membrane protein, putative |
Trypanosoma cruzi | TcCLB.508779.30 | vesicle-associated membrane protein, putative |
Trypanosoma cruzi | TcCLB.506855.140 | vesicle-associated membrane protein, putative |
Toxoplasma gondii | TGME49_248100 | synaptobrevin protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.790 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.790 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.790 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.790 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.5.3560 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.3560 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.3560 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.3560 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F23H12.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_248100 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.