pI: 7.5056 |
Length (AA): 568 |
MW (Da): 61472 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 524 | 4b2t (H) | 6 | 523 | 62.00 | 0 | 1 | 1.56333 | -0.18 |
209 | 363 | 1ass (A) | 1 | 152 | 31.00 | 0 | 1 | 0.729187 | -0.93 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127782)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G11830 | TCP-1/cpn60 chaperonin family protein |
Babesia bovis | BBOV_IV006970 | T-complex protein 1 eta subunit, putative |
Brugia malayi | Bm1_22985 | T-complex protein 1, eta subunit |
Candida albicans | CaO19.3206 | similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Candida albicans | CaO19.10718 | similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Caenorhabditis elegans | CELE_T10B5.5 | Protein CCT-7, isoform B |
Cryptosporidium hominis | Chro.40440 | T-complex protein 1 |
Cryptosporidium parvum | cgd4_3860 | TCP-1/cpn60 chaperonin family, T-complex protein subunit 7 (eta) |
Dictyostelium discoideum | DDB_G0291225 | chaperonin containing TCP1 eta subunit |
Drosophila melanogaster | Dmel_CG8351 | CG8351 gene product from transcript CG8351-RA |
Echinococcus granulosus | EgrG_000576700 | T complex protein 1 subunit eta |
Entamoeba histolytica | EHI_083260 | T-complex protein 1 subunit eta, putative |
Entamoeba histolytica | EHI_044940 | T-complex protein 1 subunit eta, putative |
Echinococcus multilocularis | EmuJ_000576700 | T complex protein 1 subunit eta |
Giardia lamblia | GL50803_16124 | TCP-1 chaperonin subunit eta |
Homo sapiens | ENSG00000135624 | chaperonin containing TCP1, subunit 7 (eta) |
Leishmania braziliensis | LbrM.34.3840 | T-complex protein 1, eta subunit, putative |
Leishmania donovani | LdBPK_353900.1 | T-complex protein 1, eta subunit, putative |
Leishmania infantum | LinJ.35.3900 | T-complex protein 1, eta subunit, putative |
Leishmania major | LmjF.35.3860 | T-complex protein 1, eta subunit, putative |
Leishmania mexicana | LmxM.34.3860 | T-complex protein 1, eta subunit, putative |
Loa Loa (eye worm) | LOAG_00662 | T-complex protein 1 |
Mus musculus | ENSMUSG00000030007 | chaperonin containing Tcp1, subunit 7 (eta) |
Neospora caninum | NCLIV_006510 | TCP-1/cpn60 family chaperonin, putative |
Oryza sativa | 4341893 | Os06g0687700 |
Plasmodium berghei | PBANKA_0406500 | T-complex protein 1 subunit eta, putative |
Plasmodium falciparum | PF3D7_0308200 | T-complex protein 1 subunit eta |
Plasmodium knowlesi | PKNH_0834500 | T-complex protein 1 subunit eta, putative |
Plasmodium vivax | PVX_119530 | T-complex protein 1 subunit eta, putative |
Plasmodium yoelii | PY01933 | chaperonin, 60 kDa |
Saccharomyces cerevisiae | YJL111W | Cct7p |
Schistosoma japonicum | Sjp_0211340 | ko:K09499 T-complex protein 1 subunit eta, putative |
Schistosoma mansoni | Smp_149900 | chaperonin containing t-complex protein 1 eta subunit tcph |
Schmidtea mediterranea | mk4.015406.00 | |
Trypanosoma brucei gambiense | Tbg972.9.6730 | T-complex protein 1, eta subunit, putative,t- complex protein 1 (eta subunit), putative |
Trypanosoma brucei | Tb927.9.11270 | t- complex protein 1 (eta subunit), putative |
Trypanosoma congolense | TcIL3000_9_4650 | t- complex protein 1 (eta subunit), putative |
Trypanosoma cruzi | TcCLB.508461.410 | T-complex protein 1, eta subunit, putative |
Toxoplasma gondii | TGME49_297500 | T-complex protein 1 eta subunit |
Theileria parva | TP03_0210 | T-complex protein 1, eta subunit, putative |
Trichomonas vaginalis | TVAG_182370 | chaperonin containing t-complex protein 1, gamma subunit, tcpg, putative |
Trichomonas vaginalis | TVAG_398480 | chaperonin-60kD, ch60, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.2570 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.2570 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.2570 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.211.2570 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T10B5.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T10B5.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T10B5.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T10B5.5 | Caenorhabditis elegans | sterile | wormbase |
YJL111W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0406500 | Plasmodium berghei | Essential | plasmo |
TGME49_297500 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaaca fascicularis | T-complex protein 1 subunit beta | 535 aa | 34.6% | 518 aa | Compounds | References |
1 literature reference was collected for this gene.