pI: 7.8815 |
Length (AA): 117 |
MW (Da): 13287 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Bloodstream Form. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126829)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G08990 | yippee family putative zinc-binding protein |
Arabidopsis thaliana | AT4G27740 | Yippee family putative zinc-binding protein |
Arabidopsis thaliana | AT3G11230 | Yippee family putative zinc-binding protein |
Arabidopsis thaliana | AT4G27745 | Yippee family putative zinc-binding protein |
Arabidopsis thaliana | AT3G55890 | yippee family putative zinc-binding protein |
Arabidopsis thaliana | AT5G53940 | yippee-like zinc-binding protein |
Arabidopsis thaliana | AT2G40110 | Yippee family putative zinc-binding protein |
Babesia bovis | BBOV_III011030 | yippee putative zinc-binding protein |
Brugia malayi | Bm1_06485 | Yippee-like protein 5 |
Candida albicans | CaO19.10876 | similar to S. cerevisiae YBL049W |
Candida albicans | CaO19.3369 | similar to D. melanogaster CG15309 gene product |
Caenorhabditis elegans | CELE_F37A8.5 | Protein F37A8.5 |
Caenorhabditis elegans | CELE_B0546.4 | Protein B0546.4, isoform B |
Dictyostelium discoideum | DDB_G0267990 | yippee-like protein |
Drosophila melanogaster | Dmel_CG15309 | CG15309 gene product from transcript CG15309-RC |
Drosophila melanogaster | Dmel_CG1989 | CG1989 gene product from transcript CG1989-RA |
Echinococcus granulosus | EgrG_000146800 | yippee protein |
Echinococcus granulosus | EgrG_000422000 | yippee protein |
Echinococcus granulosus | EgrG_000532500 | fad NAD binding oxidoreductases |
Echinococcus multilocularis | EmuJ_000137400 | protein yippee 1 |
Echinococcus multilocularis | EmuJ_000146800 | yippee protein |
Echinococcus multilocularis | EmuJ_000532500 | fad NAD binding oxidoreductases |
Echinococcus multilocularis | EmuJ_000422000 | yippee protein |
Homo sapiens | ENSG00000166793 | yippee-like 4 (Drosophila) |
Homo sapiens | ENSG00000119801 | yippee-like 5 (Drosophila) |
Homo sapiens | ENSG00000090238 | yippee-like 3 (Drosophila) |
Homo sapiens | ENSG00000100027 | yippee-like 1 (Drosophila) |
Homo sapiens | ENSG00000175155 | yippee-like 2 (Drosophila) |
Leishmania braziliensis | LbrM.30.3510 | zinc-binding protein (Yippee), putative |
Leishmania donovani | LdBPK_303520.1 | zinc-binding protein (Yippee), putative |
Leishmania infantum | LinJ.30.3520 | zinc-binding protein (Yippee), putative |
Leishmania major | LmjF.30.3460 | zinc-binding protein (Yippee), putative |
Leishmania mexicana | LmxM.29.3460 | zinc-binding protein (Yippee), putative |
Loa Loa (eye worm) | LOAG_15888 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15216 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06777 | hypothetical protein |
Mus musculus | ENSMUSG00000042675 | yippee-like 3 (Drosophila) |
Mus musculus | ENSMUSG00000018427 | yippee-like 2 (Drosophila) |
Mus musculus | ENSMUSG00000039770 | yippee-like 5 (Drosophila) |
Mus musculus | 241525 | yippee-like 4 (Drosophila) |
Neospora caninum | NCLIV_046350 | hypothetical protein |
Oryza sativa | 9269636 | Os10g0369300 |
Oryza sativa | 4333809 | Os03g0698500 |
Oryza sativa | 4343737 | Os07g0584000 |
Oryza sativa | 9270536 | Os03g0193075 |
Oryza sativa | 4352226 | Os12g0484700 |
Oryza sativa | 4350710 | Os11g0551800 |
Oryza sativa | 9271275 | Os10g0369500 |
Plasmodium berghei | PBANKA_0826400 | zinc binding protein (Yippee), putative |
Plasmodium falciparum | PF3D7_0925600 | zinc binding protein (Yippee), putative |
Plasmodium knowlesi | PKNH_0723500 | zinc binding protein (Yippee), putative |
Plasmodium vivax | PVX_099695 | zinc binding protein (Yippee), putative |
Plasmodium yoelii | PY03878 | hypothetical protein |
Saccharomyces cerevisiae | YBL049W | Moh1p |
Schistosoma japonicum | Sjp_0048700 | ko:K08791 LATS, large tumor suppressor, putative |
Schistosoma japonicum | Sjp_0317520 | expressed protein |
Schistosoma japonicum | Sjp_0078540 | Protein yippee, putative |
Schistosoma japonicum | Sjp_0028780 | Protein yippee-like 1, putative |
Schistosoma japonicum | Sjp_0021300 | Protein yippee-like CG15309, putative |
Schistosoma mansoni | Smp_152180 | fad NAD binding oxidoreductases |
Schistosoma mansoni | Smp_171850 | yippee protein |
Schmidtea mediterranea | mk4.000286.16 | |
Schmidtea mediterranea | mk4.000740.01 | |
Schmidtea mediterranea | mk4.000075.00 | |
Schmidtea mediterranea | mk4.000264.01 | |
Trypanosoma brucei gambiense | Tbg972.6.4640 | zinc-binding protein (Yippee), putative |
Trypanosoma brucei | Tb927.6.4810 | zinc-binding protein (Yippee), putative |
Trypanosoma congolense | TcIL3000_6_4280 | zinc-binding protein (Yippee), putative |
Trypanosoma cruzi | TcCLB.506835.150 | zinc-binding protein (Yippee), putative |
Trypanosoma cruzi | TcCLB.506945.105 | zinc-binding protein (Yippee), putative |
Toxoplasma gondii | TGME49_226640 | zinc binding protein, putative |
Theileria parva | TP02_0036 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.4810 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4810 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4810 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.4810 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_B0546.4 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_0826400 | Plasmodium berghei | Dispensable | plasmo |
TGME49_226640 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.