Detailed view for Tb927.11.4820

Basic information

TDR Targets ID: 15576
Trypanosoma brucei, 60S ribosomal protein L17, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.6247 | Length (AA): 166 | MW (Da): 19106 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00237   Ribosomal protein L22p/L17e

Gene Ontology

Mouse over links to read term descriptions.
GO:0022625   cytosolic large ribosomal subunit  
GO:0015934   large ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

PDB tag
  • 3ZF7:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_126900)

Species Accession Gene Product
Arabidopsis thaliana AT1G27400   60S ribosomal protein L17-1
Arabidopsis thaliana AT1G67430   60S ribosomal protein L17-2
Babesia bovis BBOV_I004110   ribosomal protein L17, putative
Brugia malayi Bm1_06635   60S ribosomal protein L17
Candida albicans CaO19.4490   likely cytosolic ribosomal protein similar to S. cerevisiae RPL17B (YJL177W) large subunit protein L17
Candida albicans CaO19.11966   likely cytosolic ribosomal protein similar to S. cerevisiae RPL17B (YJL177W) large subunit protein L17
Caenorhabditis elegans CELE_Y48G8AL.8   Protein RPL-17, isoform A
Cryptosporidium hominis Chro.80397   similar to ribosomal protein L17
Cryptosporidium parvum cgd8_3450   60S ribosomal protein L17
Dictyostelium discoideum DDB_G0285277   S60 ribosomal protein L17
Drosophila melanogaster Dmel_CG3203   Ribosomal protein L17
Echinococcus granulosus EgrG_000179400   60S ribosomal protein L17
Entamoeba histolytica EHI_127330   ribosomal protein L17, putative
Entamoeba histolytica EHI_054740   ribosomal protein L17, putative
Entamoeba histolytica EHI_008620   ribosomal protein L17, putative
Echinococcus multilocularis EmuJ_000179400   60S ribosomal protein L17
Giardia lamblia GL50803_98056   Ribosomal protein L17
Homo sapiens ENSG00000177576   RPL17-C18orf32 readthrough
Homo sapiens ENSG00000265681   ribosomal protein L17
Leishmania braziliensis LbrM.24.0040   60S ribosomal protein L17, putative
Leishmania braziliensis LbrM.32.0500   60S ribosomal protein L17, putative
Leishmania donovani LdBPK_240040.1   60S ribosomal protein L17, putative
Leishmania infantum LinJ.24.0040   60S ribosomal protein L17, putative
Leishmania infantum LinJ.32.0440   60S ribosomal protein L17, putative
Leishmania major LmjF.32.0430   60S ribosomal protein L17, putative
Leishmania major LmjF.24.0040   60S ribosomal protein L17, putative
Leishmania mexicana LmxM.24.0040   60S ribosomal protein L17, putative
Leishmania mexicana LmxM.31.0430   60S ribosomal protein L17, putative
Loa Loa (eye worm) LOAG_08629   60S ribosomal protein L17
Mus musculus ENSMUSG00000062328   ribosomal protein L17
Mus musculus 102641245   60S ribosomal protein L17-like
Mus musculus 101056140   60S ribosomal protein L17-like
Mus musculus 102632224   60S ribosomal protein L17-like
Mus musculus 100040929   predicted gene 10362
Neospora caninum NCLIV_009450   60S ribosomal protein L17, related
Oryza sativa 4346123   Os08g0530200
Oryza sativa 4346540   Os09g0258600
Plasmodium berghei PBANKA_1364200   60S ribosomal protein L17, putative
Plasmodium falciparum PF3D7_1351400   60S ribosomal protein L17, putative
Plasmodium knowlesi PKNH_1249500   60S ribosomal protein L17, putative
Plasmodium vivax PVX_083465   60S ribosomal protein L17, putative
Plasmodium yoelii PY00934   ribosomal protein L22
Saccharomyces cerevisiae YJL177W   ribosomal 60S subunit protein L17B
Saccharomyces cerevisiae YKL180W   ribosomal 60S subunit protein L17A
Schistosoma japonicum Sjp_0307930   60S ribosomal protein L17, putative
Schistosoma japonicum Sjp_0034040   ko:K02880 large subunit ribosomal protein L17e, putative
Schistosoma mansoni Smp_024850   60S ribosomal protein L17
Schmidtea mediterranea mk4.000310.16   60S ribosomal protein L17
Trypanosoma brucei gambiense Tbg972.10.17730   60S ribosomal protein L17, putative
Trypanosoma brucei gambiense Tbg972.11.5440   60S ribosomal protein L17, putative
Trypanosoma brucei Tb927.11.4820   60S ribosomal protein L17, putative
Trypanosoma brucei Tb927.10.14580   60S ribosomal protein L17, putative
Trypanosoma congolense TcIL3000_10_12470   60S ribosomal protein L17, putative
Trypanosoma cruzi TcCLB.511287.30   60S ribosomal protein L17, putative
Trypanosoma cruzi TcCLB.503449.10   60S ribosomal protein L17, putative
Trypanosoma cruzi TcCLB.506213.80   60S ribosomal protein L17, putative
Trypanosoma cruzi TcCLB.509875.210   60S ribosomal protein L17, putative
Toxoplasma gondii TGME49_299050   ribosomal protein RPL17
Theileria parva TP02_0720   60S ribosomal protein L17, putative
Trichomonas vaginalis TVAG_473910   60S ribosomal protein L17, putative
Trichomonas vaginalis TVAG_296170   60S ribosomal protein L17, putative
Trichomonas vaginalis TVAG_083260   60S ribosomal protein L17, putative
Trichomonas vaginalis TVAG_109440   60S ribosomal protein L17, putative

Essentiality

Tb927.11.4820 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.2430 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.2430 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.2430 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.2430 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.14580 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.14580 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.14580 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.14580 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y48G8AL.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y48G8AL.8 Caenorhabditis elegans larval arrest wormbase
CELE_Y48G8AL.8 Caenorhabditis elegans slow growth wormbase
CELE_Y48G8AL.8 Caenorhabditis elegans sterile wormbase
YKL180W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1364200 Plasmodium berghei Essential plasmo
TGME49_299050 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Tb927.11.4820 (Trypanosoma brucei), 60S ribosomal protein L17, putative
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