pI: 4.8943 |
Length (AA): 555 |
MW (Da): 60760 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
67 | 158 | 2o11 (A) | 304 | 389 | 35.00 | 0.056 | 0.26 | 0.330568 | 0.93 |
163 | 471 | 4pq0 (A) | 232 | 473 | 22.00 | 0 | 1 | 0.531755 | 0.17 |
188 | 466 | 4ifs (A) | 199 | 421 | 22.00 | 0 | 1 | 0.574299 | -0.28 |
292 | 340 | 5ez1 (A) | 152 | 200 | 33.00 | 0.93 | 0.46 | 0.441229 | 0.15 |
360 | 511 | 4z2n (A) | 787 | 926 | 17.00 | 0 | 0.27 | 0.303881 | 0.21 |
446 | 525 | 1qbk (B) | 281 | 377 | 39.00 | 0.0082 | 0.04 | 0.265985 | 0.94 |
471 | 517 | 5chl (A) | 16 | 71 | 30.00 | 0 | 0 | 0.194032 | -0.25 |
477 | 545 | 5bs7 (E) | 606 | 674 | 19.00 | 0 | 0.01 | 0.416601 | -1.27 |
496 | 545 | 1qkl (A) | 802 | 850 | 41.00 | 0.36 | 0.23 | 0.511028 | -0.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127386)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G28730 | FACT complex subunit SSRP1 |
Babesia bovis | BBOV_III003170 | structure specific recognition protein, putative |
Brugia malayi | Bm1_18530 | structure-specific recognition protein 1 |
Candida albicans | CaO19.9133 | similar to S. cerevisiae POB3 (YML069W) DNA Polymerase binding protein and RNA Pol II transcriptional elongation regulator invol |
Candida albicans | CaO19.1560 | similar to S. cerevisiaePOB3 (YML069W) DNA Polymerase binding protein and RNA Pol II transcriptional elongation regulator involv |
Caenorhabditis elegans | CELE_C32F10.5 | Protein HMG-3 |
Caenorhabditis elegans | CELE_T20B12.8 | Protein HMG-4 |
Cryptosporidium hominis | Chro.70588 | structure specific recognition protein |
Cryptosporidium parvum | cgd7_5280 | structure-specific recognition protein 1 (SSRP1) (recombination signal sequence recognition protein) |
Dictyostelium discoideum | DDB_G0290331 | FACT complex subunit SSRP1 |
Drosophila melanogaster | Dmel_CG4817 | Structure specific recognition protein |
Echinococcus granulosus | EgrG_000894800 | fact complex subunit ssrp1 |
Entamoeba histolytica | EHI_082500 | structure specific recognition protein, putative |
Echinococcus multilocularis | EmuJ_000894800 | fact complex subunit ssrp1 |
Homo sapiens | ENSG00000149136 | structure specific recognition protein 1 |
Leishmania braziliensis | LbrM.32.0280 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_320220.1 | Histone chaperone Rttp106-like, putative |
Leishmania infantum | LinJ.32.0220 | hypothetical protein, conserved |
Leishmania major | LmjF.32.0210 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.31.0210 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04347 | structure-specific recognition protein 1 |
Mus musculus | ENSMUSG00000027067 | structure specific recognition protein 1 |
Neospora caninum | NCLIV_026040 | structure specific recognition protein I, putative |
Oryza sativa | 4325652 | Os01g0184900 |
Oryza sativa | 4337994 | Os05g0182600 |
Onchocerca volvulus | OVOC7702 | FACT complex subunit SSRP1 homolog |
Plasmodium berghei | PBANKA_1305300 | FACT complex subunit SSRP1, putative |
Plasmodium falciparum | PF3D7_1441400 | FACT complex subunit SSRP1, putative |
Plasmodium knowlesi | PKNH_1240900 | FACT complex subunit SSRP1, putative |
Plasmodium vivax | PVX_118420 | FACT complex subunit SSRP1, putative |
Plasmodium yoelii | PY06541 | structure-specific recognition protein 1 |
Plasmodium yoelii | PY06012 | putative structure specific recognition protein |
Saccharomyces cerevisiae | YML069W | FACT complex subunit POB3 |
Schistosoma japonicum | Sjp_0035580 | ko:K09272 structure-specific recognition protein 1, putative |
Schistosoma mansoni | Smp_148930 | structure specific recognition protein |
Trypanosoma brucei gambiense | Tbg972.10.17490 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.14390 | Histone chaperone Rttp106-like, putative |
Trypanosoma congolense | TcIL3000_10_12240 | Histone chaperone Rttp106-like, putative |
Trypanosoma cruzi | TcCLB.511283.220 | Histone chaperone Rttp106-like, putative |
Toxoplasma gondii | TGME49_261460 | transcriptional elongation factor FACT80 |
Theileria parva | TP04_0129 | structure specific recognition protein, putative |
Trichomonas vaginalis | TVAG_192570 | structure-specific recognition protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14390 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14390 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14390 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.14390 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C32F10.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C32F10.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C32F10.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C32F10.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C32F10.5 | Caenorhabditis elegans | sterile | wormbase |
CELE_T20B12.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T20B12.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T20B12.8 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T20B12.8 | Caenorhabditis elegans | slow growth | wormbase |
YML069W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1305300 | Plasmodium berghei | Essential | plasmo |
TGME49_261460 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.