pI: 10.4231 |
Length (AA): 393 |
MW (Da): 43527 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 8
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128426)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G56090 | cytochrome c oxidase assembly protein COX15 |
Babesia bovis | BBOV_III002290 | cytochrome c oxidase assembly protein, putative |
Brugia malayi | Bm1_07665 | Cytochrome oxidase assembly protein |
Candida albicans | CaO19.3656 | cytochrome oxidase assembly |
Candida albicans | CaO19.11140 | cytochrome oxidase assembly |
Caenorhabditis elegans | CELE_T06D8.5 | Protein T06D8.5 |
Dictyostelium discoideum | DDB_G0281549 | cytochrome c oxidase assembly protein |
Drosophila melanogaster | Dmel_CG3803 | CG3803 gene product from transcript CG3803-RA |
Echinococcus granulosus | EgrG_000451100 | cytochrome c oxidase subunit XV assembly |
Echinococcus multilocularis | EmuJ_000451100 | cytochrome c oxidase subunit XV assembly |
Homo sapiens | 1355 | cytochrome c oxidase assembly homolog 15 (yeast) |
Leishmania braziliensis | LbrM.28.2890 | cytochrome oxidase assembly protein-like protein |
Leishmania donovani | LdBPK_282880.1 | cytochrome oxidase assembly protein-like protein |
Leishmania infantum | LinJ.28.2880 | cytochrome oxidase assembly protein-like protein |
Leishmania major | LmjF.28.2680 | cytochrome oxidase assembly protein-like protein |
Leishmania mexicana | LmxM.28.2680 | cytochrome oxidase assembly protein-like protein |
Loa Loa (eye worm) | LOAG_08709 | hypothetical protein |
Mus musculus | ENSMUSG00000040018 | cytochrome c oxidase assembly protein 15 |
Neospora caninum | NCLIV_045250 | cytochrome C oxidase assembly factor COX15, putative |
Oryza sativa | 4345926 | Os08g0496000 |
Plasmodium berghei | PBANKA_1009800 | cytochrome c oxidase assembly protein COX15, putative |
Plasmodium falciparum | PF3D7_1435000 | cytochrome c oxidase assembly protein COX15, putative |
Plasmodium knowlesi | PKNH_0421600 | cytochrome c oxidase assembly protein COX15, putative |
Plasmodium vivax | PVX_084785 | cytochrome c oxidase assembly protein, putative |
Plasmodium yoelii | PY02555 | cytochrome c oxidase assembly protein |
Saccharomyces cerevisiae | YER141W | Cox15p |
Schistosoma japonicum | Sjp_0302460 | ko:K02259 cytochrome c oxidase subunit XV assembly protein, putative |
Schistosoma mansoni | Smp_147510 | cytochrome C oxidase assembly protein cox15 |
Schmidtea mediterranea | mk4.002473.04 | Cytochrome c oxidase assembly protein COX15 homolog |
Schmidtea mediterranea | mk4.012403.00 | Cytochrome c oxidase assembly protein COX15 homolog |
Trypanosoma brucei gambiense | Tbg972.11.13410 | cytochrome oxidase assembly protein, putative |
Trypanosoma brucei | Tb927.11.11950 | cytochrome oxidase assembly protein, putative |
Trypanosoma congolense | TcIL3000.11.12610 | cytochrome oxidase assembly protein, putative |
Trypanosoma cruzi | TcCLB.511211.70 | cytochrome c oxidase assembly protein |
Toxoplasma gondii | TGME49_228180 | cytochrome C oxidase assembly factor COX15, putative |
Theileria parva | TP03_0594 | cytochrome c oxidase assembly protein, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0456 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.3780 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.3780 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.3780 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.3780 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T06D8.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T06D8.5 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1009800 | Plasmodium berghei | Essential | plasmo |
TGME49_228180 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.