pI: 4.5197 |
Length (AA): 166 |
MW (Da): 17820 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
15 | 164 | 1xtd (A) | 24 | 172 | 83.00 | 0 | 1 | 1.89891 | -0.76 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126922)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G69410 | eukaryotic translation initiation factor 5A-3 |
Arabidopsis thaliana | AT1G13950 | translation initiation factor eIF-5A |
Arabidopsis thaliana | AT1G26630 | eukaryotic translation initiation factor 5A-2 |
Babesia bovis | BBOV_IV008910 | translation initiation factor 5A, putative |
Brugia malayi | Bm1_57565 | Eukaryotic translation initiation factor 5A-2 |
Candida albicans | CaO19.10930 | similar to both S. cerevisiae versions of hypusine-containing translation initiation factor eIF-5A, putative sensor of intracell |
Candida albicans | CaO19.3426 | similar to both S. cerevisiae versions of hypusine-containing translation initiation factor eIF-5A, putative sensor of intracell |
Caenorhabditis elegans | CELE_F54C9.1 | Protein IFF-2 |
Caenorhabditis elegans | CELE_T05G5.10 | Protein IFF-1, isoform C |
Cryptosporidium hominis | Chro.70262 | translation initiation factor 5A2 |
Cryptosporidium parvum | cgd7_2300 | translation initiation factor if-5A |
Dictyostelium discoideum | DDB_G0284861 | eukaryotic translation initiation factor 5A |
Drosophila melanogaster | Dmel_CG3186 | CG3186 gene product from transcript CG3186-RB |
Echinococcus granulosus | EgrG_000749800 | eukaryotic translation initiation factor 5A |
Entamoeba histolytica | EHI_186480 | translation initiation factor eIF-5A, putative |
Entamoeba histolytica | EHI_177460 | translation initiation factor eIF-5A, putative |
Entamoeba histolytica | EHI_151540 | translation initiation factor eIF-5A, putative |
Entamoeba histolytica | EHI_151810 | translation initiation factor eIF-5A, putative |
Echinococcus multilocularis | EmuJ_000749800 | eukaryotic translation initiation factor 5A |
Giardia lamblia | GL50803_14614 | Eukaryotic translation initiation factor 5A |
Homo sapiens | ENSG00000132507 | eukaryotic translation initiation factor 5A |
Homo sapiens | ENSG00000163577 | eukaryotic translation initiation factor 5A2 |
Homo sapiens | ENSG00000253626 | eukaryotic translation initiation factor 5A-like 1 |
Leishmania braziliensis | LbrM.25.0580 | eukaryotic initiation factor 5a, putative |
Leishmania braziliensis | LbrM.25.0590 | eukaryotic initiation factor 5a, putative |
Leishmania braziliensis | LbrM.25.0600 | eukaryotic initiation factor 5a, putative |
Leishmania braziliensis | LbrM.25.0610 | eukaryotic initiation factor 5a, putative |
Leishmania donovani | LdBPK_250740.1 | eukaryotic initiation factor 5a, putative |
Leishmania donovani | LdBPK_250750.1 | eukaryotic initiation factor 5a, putative |
Leishmania infantum | LinJ.25.0750 | eukaryotic initiation factor 5a, putative |
Leishmania infantum | LinJ.25.0760 | eukaryotic initiation factor 5a, putative |
Leishmania infantum | LinJ.25.0740 | eukaryotic initiation factor 5a, putative |
Leishmania major | LmjF.25.0720 | eukaryotic initiation factor 5a, putative |
Leishmania major | LmjF.25.0730 | eukaryotic initiation factor 5a, putative |
Leishmania mexicana | LmxM.25.0730 | eukaryotic initiation factor 5a, putative |
Leishmania mexicana | LmxM.25.0720 | eukaryotic initiation factor 5a, putative |
Loa Loa (eye worm) | LOAG_01764 | eukaryotic translation initiation factor 5A-2 |
Mus musculus | ENSMUSG00000078812 | eukaryotic translation initiation factor 5A |
Mus musculus | ENSMUSG00000050192 | eukaryotic translation initiation factor 5A2 |
Neospora caninum | NCLIV_066870 | hypothetical protein |
Oryza sativa | 4342241 | Os07g0112800 |
Oryza sativa | 4343796 | Os07g0597000 |
Oryza sativa | 9268063 | Os07g0236250 |
Oryza sativa | 4352300 | Os12g0507200 |
Oryza sativa | 4334177 | Os03g0758800 |
Onchocerca volvulus | OVOC11437 | Eukaryotic translation initiation factor 5A homolog |
Plasmodium berghei | PBANKA_0603200 | eukaryotic translation initiation factor 5A, putative |
Plasmodium falciparum | PF3D7_1204300 | eukaryotic translation initiation factor 5A |
Plasmodium knowlesi | PKNH_1304000 | eukaryotic translation initiation factor 5A, putative |
Plasmodium vivax | PVX_084255 | eukaryotic translation initiation factor 5A |
Plasmodium yoelii | PY00983 | translation initiation factor eIF-5A |
Saccharomyces cerevisiae | YJR047C | translation elongation factor eIF-5A |
Saccharomyces cerevisiae | YEL034W | translation elongation factor eIF-5A |
Schistosoma japonicum | Sjp_0017450 | ko:K03263 translation initiation factor eIF-5A, putative |
Schistosoma mansoni | Smp_039400 | initiation factor 5a |
Schmidtea mediterranea | mk4.004989.01 | Eukaryotic translation initiation factor 5A |
Schmidtea mediterranea | mk4.004632.01 | Eukaryotic translation initiation factor 5A |
Schmidtea mediterranea | mk4.001678.01 | Eukaryotic translation initiation factor 5A |
Schmidtea mediterranea | mk4.003167.00 | Eukaryotic translation initiation factor 5A |
Schmidtea mediterranea | mk4.006418.02 | Eukaryotic translation initiation factor 5A |
Schmidtea mediterranea | mk4.002434.00 | Eukaryotic translation initiation factor 5A |
Trypanosoma brucei gambiense | Tbg972.11.740 | eukaryotic translation initiation factor 5a, putative |
Trypanosoma brucei | Tb927.11.740 | eukaryotic translation initiation factor 5A |
Trypanosoma cruzi | TcCLB.506925.120 | eukaryotic translation initiation factor 5A |
Trypanosoma cruzi | TcCLB.506925.130 | eukaryotic translation initiation factor 5A |
Toxoplasma gondii | TGME49_251810 | translation initiation factor eIF-5A, putative |
Theileria parva | TP01_0884 | eukaryotic translation initiation factor 5A, putative |
Trichomonas vaginalis | TVAG_361780 | initiation factor 5A, putative |
Trichomonas vaginalis | TVAG_283020 | initiation factor 5A, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.03.0410 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.03.0410 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.03.0410 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.03.0410 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T05G5.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T05G5.10 | Caenorhabditis elegans | sterile | wormbase |
CELE_F54C9.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F54C9.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F54C9.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F54C9.1 | Caenorhabditis elegans | sterile | wormbase |
YEL034W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_251810 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.