pI: 9.0213 |
Length (AA): 373 |
MW (Da): 44608 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
45 | 350 | 4p17 (A) | 9 | 307 | 33.00 | 0 | 1 | 1.27488 | -1.24 |
45 | 351 | 4p17 (A) | 9 | 308 | 28.00 | 0 | 1 | 1.19066 | -0.68 |
79 | 367 | 3hzj (A) | 513 | 796 | 26.00 | 0 | 1 | 1.1683 | -1.03 |
168 | 315 | 3k3k (A) | 12 | 171 | 35.00 | 0.93 | 0.19 | 0.277283 | 1.69 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, merozoite, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Male Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 32 hs, late ring, Female Gametocyte. | Otto TD PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Sporozoite. | Zanghi G |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_127311)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G07890 | RabGAP/TBC domain-containing protein |
Babesia bovis | BBOV_IV005540 | RabGAP/TBC domain-containing protein, putative |
Brugia malayi | Bm1_04155 | TBC domain containing protein |
Brugia malayi | Bm1_43015 | TBC domain containing protein |
Candida albicans | CaO19.8209 | GTPase-activating protein for Sec4p |
Candida albicans | CaO19.578 | GTPase-activating protein for Sec4p |
Caenorhabditis elegans | CELE_C04A2.1 | Protein TBC-6 |
Caenorhabditis elegans | CELE_ZK1248.10 | Protein TBC-2 |
Caenorhabditis elegans | CELE_C31E10.8 | Protein TBC-19 |
Dictyostelium discoideum | DDB_G0275345 | hypothetical protein |
Drosophila melanogaster | Dmel_CG5916 | CG5916 gene product from transcript CG5916-RB |
Echinococcus granulosus | EgrG_000523200 | TBC1 domain family B |
Echinococcus granulosus | EgrG_001184100 | growth hormone regulated TBC protein 1 A |
Echinococcus granulosus | EgrG_000523000 | tbc tre 2:bub2:cdc16 domain family member |
Echinococcus multilocularis | EmuJ_000523000 | tbc (tre 2:bub2:cdc16) domain family member |
Echinococcus multilocularis | EmuJ_000523200 | TBC1 domain family B |
Echinococcus multilocularis | EmuJ_000567800 | growth hormone regulated TBC protein |
Echinococcus multilocularis | EmuJ_001184100 | growth hormone regulated TBC protein 1 A |
Homo sapiens | ENSG00000167202 | TBC1 domain family, member 2B |
Homo sapiens | ENSG00000095383 | TBC1 domain family, member 2 |
Homo sapiens | ENSG00000139835 | growth hormone regulated TBC protein 1 |
Leishmania braziliensis | LbrM.29.1650 | GTPase activator protein, putative |
Leishmania mexicana | LmxM.08_29.1560 | GTPase activator protein, putative |
Loa Loa (eye worm) | LOAG_08500 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12385 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10835 | TBC domain-containing protein |
Loa Loa (eye worm) | LOAG_13593 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14117 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14724 | hypothetical protein |
Mus musculus | 102637899 | predicted gene, 34595 |
Mus musculus | ENSMUSG00000039813 | TBC1 domain family, member 2 |
Mus musculus | ENSMUSG00000038515 | GH regulated TBC protein 1 |
Mus musculus | ENSMUSG00000037410 | TBC1 domain family, member 2B |
Neospora caninum | NCLIV_026190 | Ankyrin repeat-containing protein, related |
Oryza sativa | 4345310 | Os08g0337700 |
Onchocerca volvulus | OVOC3300 |
|
Onchocerca volvulus | OVOC3297 |
|
Plasmodium berghei | PBANKA_0933400 | GTPase-activating protein, putative |
Plasmodium falciparum | PF3D7_1114200 | GTPase-activating protein, putative |
Plasmodium knowlesi | PKNH_0911800 | GTPase-activating protein, putative |
Plasmodium vivax | PVX_091355 | hypothetical protein, conserved |
Plasmodium yoelii | PY00727 | hypothetical protein |
Saccharomyces cerevisiae | YNL293W | Msb3p |
Saccharomyces cerevisiae | YOL112W | Msb4p |
Schistosoma japonicum | Sjp_0061840 | Growth hormone-regulated TBC protein 1, putative |
Schistosoma japonicum | Sjp_0305770 | Growth hormone-regulated TBC protein 1, putative |
Schistosoma japonicum | Sjp_0044490 | TBC1 domain family member 2B, putative |
Schistosoma japonicum | Sjp_0044510 | hypothetical protein |
Schistosoma japonicum | Sjp_0044500 | hypothetical protein |
Schistosoma mansoni | Smp_001420 | gh regulated tbc protein-1 |
Schistosoma mansoni | Smp_160470 | hypothetical protein |
Schmidtea mediterranea | mk4.024480.00 | Gh regulated tbc protein-1, putative |
Schmidtea mediterranea | mk4.004874.04 | Gh regulated tbc protein-1, putative |
Schmidtea mediterranea | mk4.001566.00 | Gh regulated tbc protein-1, putative |
Trypanosoma cruzi | TcCLB.506175.60 | GTPase activator protein, putative |
Trypanosoma cruzi | TcCLB.509669.110 | GTPase activator protein, putative |
Toxoplasma gondii | TGME49_261200 | TBC domain-containing protein |
Theileria parva | TP01_0360 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_087290 | gh regulated tbc protein-1, putative |
Trichomonas vaginalis | TVAG_265570 | run and tbc1 domain containing 3, plant, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_ZK1248.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK1248.10 | Caenorhabditis elegans | sterile | wormbase |
TGME49_261200 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.