pI: 8.7571 |
Length (AA): 302 |
MW (Da): 32267 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 6
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
98 | 298 | 4pgr (A) | 10 | 208 | 18.00 | 0 | 0.34 | 0.843763 | -0.23 |
135 | 245 | 4hyg (A) | 28 | 130 | 37.00 | 0.37 | 0.03 | 0.22125 | 2.55 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_129362)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G47120 | BAX inhibitor 1 |
Babesia bovis | BBOV_I000430 | Bax inhibitor-1, putative |
Brugia malayi | Bm1_27535 | Uncharacterized protein family UPF0005 containing protein |
Cryptosporidium hominis | Chro.60342 | bax inhibitor-1 |
Cryptosporidium parvum | cgd6_2960 | Bax inhibitor-1 (BI-1). integral membrane protien with 6 or more transmembrane domains |
Dictyostelium discoideum | DDB_G0287617 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7188 | Bax Inhibitor-1 |
Escherichia coli | b0970 | HflBKC-binding inner membrane protein, UPF0005 family |
Echinococcus granulosus | EgrG_001071100 | Bax inhibitor 1 |
Entamoeba histolytica | EHI_169290 | Bax inhibitor, putative |
Echinococcus multilocularis | EmuJ_001071100 | Bax inhibitor 1 |
Homo sapiens | ENSG00000139644 | transmembrane BAX inhibitor motif containing 6 |
Leishmania braziliensis | LbrM.24.1210 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_241220.1 | Inhibitor of apoptosis-promoting Bax1, putative |
Leishmania infantum | LinJ.24.1220 | hypothetical protein, conserved |
Leishmania major | LmjF.24.1190 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.24.1190 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_10136 | bax inhibitor I |
Mus musculus | ENSMUSG00000023010 | transmembrane BAX inhibitor motif containing 6 |
Neospora caninum | NCLIV_029150 | Bax inhibitor 1, related |
Oryza sativa | 4328149 | Os02g0125300 |
Onchocerca volvulus | OVOC408 | Bax inhibitor 1 homolog |
Plasmodium berghei | PBANKA_1323400 | bax inhibitor 1, putative |
Plasmodium falciparum | PF3D7_1459800 | bax inhibitor 1, putative |
Plasmodium knowlesi | PKNH_1222000 | bax inhibitor 1, putative |
Plasmodium vivax | PVX_117470 | bax inhibitor 1, putative |
Plasmodium yoelii | PY05517 | hypothetical protein |
Plasmodium yoelii | PY05518 | hypothetical protein |
Schistosoma japonicum | Sjp_0304850 | Bax inhibitor 1, putative |
Schistosoma mansoni | Smp_044000 | bax inhibitor |
Schmidtea mediterranea | mk4.000101.21 | Bax inhibitor 1 |
Schmidtea mediterranea | mk4.026543.00 | |
Schmidtea mediterranea | mk4.020363.00 | Putative bax inhibitor |
Trypanosoma brucei gambiense | Tbg972.11.6570 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.5820 | Inhibitor of apoptosis-promoting Bax1, putative |
Trypanosoma congolense | TcIL3000.11.6200 | Inhibitor of apoptosis-promoting Bax1, putative |
Trypanosoma congolense | TcIL3000_0_42100 | Inhibitor of apoptosis-promoting Bax1, putative |
Trypanosoma congolense | TcIL3000.11.6230 | Inhibitor of apoptosis-promoting Bax1, putative |
Trypanosoma congolense | TcIL3000_0_02440 | Inhibitor of apoptosis-promoting Bax1, putative |
Trypanosoma cruzi | TcCLB.503487.70 | Inhibitor of apoptosis-promoting Bax1, putative |
Trypanosoma cruzi | TcCLB.508641.200 | Inhibitor of apoptosis-promoting Bax1, putative |
Toxoplasma gondii | TGME49_255900 | Bax inhibitor-1, putative |
Toxoplasma gondii | TGME49_255895 | hypothetical protein |
Theileria parva | TP02_0920 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.3570 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.3570 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.3570 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.3570 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0970 | Escherichia coli | non-essential | goodall |
TGME49_255900 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_255895 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.