Detailed view for Tb11.01.6241
Basic information
TDR Targets ID: 16545
Trypanosoma brucei, expression site-associated gene (ESAG) protein, putative
Source Database / ID: TriTrypDB GeneDB
Trypanosoma brucei, expression site-associated gene (ESAG) protein, putative
Source Database / ID: TriTrypDB GeneDB
pI: 4.9559 |
Length (AA): 455 |
MW (Da): 50755 |
Paralog Number:
17
Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
PF13206
Trypanosomal VSG domain
Gene Ontology
Mouse over links to read term descriptions.
GO:0008150
biological_process GO:0003674 molecular_function
GO:0016021 integral to membrane
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
No model available for this protein in Modbase.
PDB Structures:
No structure availble in the PDB for this protein
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| NA% percentile | Procyclic. | Siegel TN |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Lower 20-40% percentile | Bloodstream Form. | Siegel TN |
-
Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.
Orthologs
Ortholog group members (OG5_128143)
| Species | Accession | Gene Product |
|---|---|---|
| Trypanosoma brucei gambiense | Tbg972.3.2520 | expression site-associated gene (ESAG) protein, putative,expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei gambiense | Tbg972.1.1180 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei gambiense | Tbg972.11.16370 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei gambiense | Tbg972.11.16380 | expression site-associated gene (ESAG) protein, putative,expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei gambiense | Tbg972.4.3300 | hypothetical protein, conserved |
| Trypanosoma brucei gambiense | Tbg972.3.150 | expression site-associated gene (ESAG) protein, putative |
| Trypanosoma brucei | Tb11.v5.0788 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb927.9.7330 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb927.6.540 | gene related to expression site-associated gene 2 (GRESAG2), putative |
| Trypanosoma brucei | Tb11.v5.0789 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb927.1.5100 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb927.6.470 | gene related to expression site-associated gene 2 (GRESAG2), putative |
| Trypanosoma brucei | Tb427tmp.01.6230 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb927.6.500 | gene related to expression site-associated gene 2 (GRESAG2), putative |
| Trypanosoma brucei | Tb11.v5.0676 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb927.11.14620 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb11.01.6241 | expression site-associated gene (ESAG) protein, putative |
| Trypanosoma brucei | Tb927.1.2040 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb927.4.3290 | Trypanosomal VSG domain containing protein, putative |
| Trypanosoma brucei | Tb927.3.2510 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb927.3.570 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb927.9.7410 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb927.1.4890 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma brucei | Tb11.v5.0816 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_34060 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_49590 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_01760 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_29150 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_47860 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_53990 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_57970 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_41560 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_34950 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_18520 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_44300 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_10_2020 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_47850 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_14650 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_BAC4B1_002 | VSG |
| Trypanosoma congolense | TcIL3000_0_54690 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_10930 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_41190 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_04910 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_14660 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_39610 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_05180 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_25280 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_43520 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_10_1030 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_43530 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_26560 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_04900 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_18530 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_05210 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_49580 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_19970 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_07940 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_10_2030 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_12490 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_48250 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_38020 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_01770 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_51880 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_54700 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_25290 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_0_05190 | variant surface glycoprotein |
| Trypanosoma congolense | TcIL3000_10_1020 | expression site-associated gene 2 (ESAG2) protein, putative |
| Trypanosoma congolense | TcIL3000_0_51890 | variant surface glycoprotein |
Essentiality
Tb11.01.6241 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.4.3290 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
| Tb927.4.3290 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
| Tb927.4.3290 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
| Tb927.4.3290 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb09.v1.0320 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb09.v1.0320 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
| Tb09.v1.0320 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
| Tb09.v1.0320 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb927.1.5100 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
| Tb927.1.5100 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
| Tb927.1.5100 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb927.1.5100 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb11.01.6230 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
| Tb11.01.6230 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
| Tb11.01.6230 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb11.01.6230 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb09.160.5390 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
| Tb09.160.5390 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
| Tb09.160.5390 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb09.160.5390 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb927.1.2040 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
| Tb927.1.2040 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
| Tb927.1.2040 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb927.1.2040 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb927.1.4890 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb927.1.4890 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb927.1.4890 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
| Tb927.1.4890 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb927.6.540 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
| Tb927.6.540 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
| Tb927.6.540 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb927.6.540 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
-
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
If you have references for this gene, please enter them in a user comment (below) or Contact us.
User comments
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