Detailed view for Tb927.9.14370

Basic information

TDR Targets ID: 16621
Trypanosoma brucei, 60S ribosomal protein L26, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.6683 | Length (AA): 143 | MW (Da): 16454 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00467   KOW motif
PF16906   Ribosomal proteins L26 eukaryotic, L24P archaeal

Gene Ontology

Mouse over links to read term descriptions.
GO:0022625   cytosolic large ribosomal subunit  
GO:0015934   large ribosomal subunit  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 123 1vq8 (T) 1 119 40.00 0 1 1.39187 -0.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3ZF7:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_126931)

Species Accession Gene Product
Arabidopsis thaliana AT3G49910   60S ribosomal protein L26-1
Arabidopsis thaliana AT5G67510   60S ribosomal protein L26-2
Babesia bovis BBOV_III008670   ribosomal protein L24 family protein
Brugia malayi Bm1_47020   60S ribosomal protein L26
Caenorhabditis elegans CELE_F28C6.7   Protein RPL-26, isoform A
Cryptosporidium hominis Chro.60530   ribosomal protein L26
Cryptosporidium parvum cgd6_4620   60S ribosomal protein L26
Dictyostelium discoideum DDB_G0283741   S60 ribosomal protein L26
Drosophila melanogaster Dmel_CG6846   Ribosomal protein L26
Echinococcus granulosus EgrG_000972500   60S ribosomal protein L26
Entamoeba histolytica EHI_152570   60S ribosomal protein L26, putative
Entamoeba histolytica EHI_111570   60S ribosomal protein L26, putative
Echinococcus multilocularis EmuJ_000972500   60S ribosomal protein L26
Giardia lamblia GL50803_15046   Ribosomal protein L26
Homo sapiens ENSG00000037241   ribosomal protein L26-like 1
Homo sapiens ENSG00000161970   ribosomal protein L26
Leishmania braziliensis LbrM.24.2130   60S ribosomal protein L26, putative
Leishmania braziliensis LbrM.34.1580   60S ribosomal protein L26, putative
Leishmania infantum LinJ.24.2140   60S ribosomal protein L26, putative
Leishmania infantum LinJ.35.1670   60S ribosomal protein L26, putative
Leishmania major LmjF.24.2050   60S ribosomal protein L26, putative
Leishmania major LmjF.35.1670   60S ribosomal protein L26, putative
Leishmania mexicana LmxM.24.2050   60S ribosomal protein L26, putative
Leishmania mexicana LmxM.34.1670   60S ribosomal protein L26, putative
Loa Loa (eye worm) LOAG_06690   large subunit ribosomal protein 26
Mus musculus ENSMUSG00000060938   ribosomal protein L26
Neospora caninum NCLIV_064360   50S ribosomal protein L24P, related
Oryza sativa 4349791   Os11g0151300
Oryza sativa 4351513   Os12g0150100
Plasmodium berghei PBANKA_0410600   60S ribosomal protein L26, putative
Plasmodium falciparum PF3D7_0312800   60S ribosomal protein L26, putative
Plasmodium knowlesi PKNH_0829400   60S ribosomal protein L26, putative
Plasmodium vivax PVX_119740   60S ribosomal protein L26, putative
Plasmodium yoelii PY04507   ribosomal protein L24
Saccharomyces cerevisiae YLR344W   ribosomal 60S subunit protein L26A
Saccharomyces cerevisiae YGR034W   ribosomal 60S subunit protein L26B
Schistosoma japonicum Sjp_0032430   ko:K02898 large subunit ribosomal protein L26e, putative
Schistosoma mansoni Smp_098960   60S ribosomal protein L26
Schmidtea mediterranea mk4.000892.05  
Trypanosoma brucei gambiense Tbg972.9.9030   60S ribosomal protein L26, putative
Trypanosoma brucei gambiense Tbg972.8.6240   60S ribosomal protein L26, putative
Trypanosoma brucei Tb927.8.6180   60S ribosomal protein L26, putative
Trypanosoma brucei Tb927.9.14370   60S ribosomal protein L26, putative
Trypanosoma congolense TcIL3000_9_6170   60S ribosomal protein L26, putative
Trypanosoma cruzi TcCLB.510761.14   60S ribosomal protein L26, putative
Trypanosoma cruzi TcCLB.511903.130   60S ribosomal protein L26, putative
Trypanosoma cruzi TcCLB.511067.20   60S ribosomal protein L26, putative
Toxoplasma gondii TGME49_248390   ribosomal protein RPL26
Theileria parva TP04_0771   60S ribosomal protein L26, putative
Trichomonas vaginalis TVAG_389320   60S ribosomal protein L26, putative
Trichomonas vaginalis TVAG_237220   60S ribosomal protein L26, putative
Trichomonas vaginalis TVAG_038050   50S ribosomal protein L24p, putative
Trichomonas vaginalis TVAG_190230   60S ribosomal protein L26, putative
Trichomonas vaginalis TVAG_078160   50S ribosomal protein L24p, putative

Essentiality

Tb927.9.14370 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.4850 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.4850 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.4850 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.4850 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.6180 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.6180 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.6180 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.6180 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F28C6.7 Caenorhabditis elegans embryonic arrest wormbase
CELE_F28C6.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_F28C6.7 Caenorhabditis elegans larval arrest wormbase
CELE_F28C6.7 Caenorhabditis elegans slow growth wormbase
CELE_F28C6.7 Caenorhabditis elegans sterile wormbase
TGME49_248390 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Tb927.9.14370 (Trypanosoma brucei), 60S ribosomal protein L26, putative
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